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    Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

    Published 2022
    “…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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    Journal Article
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