Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…<p>The COVID-19 pandemic, caused by SARS-CoV-2, has profoundly impacted global health, prompting extensive research into vaccine responses and the immune dynamics of SARS-CoV2 variants of concern (VOCs). …”

Detecting changes in population trends in infection surveillance using community SARS-CoV-2 prevalence as an exemplar by Pritchard, E, Vihta, K-D, Eyre, DW, Hopkins, S, Peto, TEA, Matthews, PC, Stoesser, N, Studley, R, Rourke, E, Diamond, I, Pouwels, KB, Walker, AS, COVID-19 Infection Survey Team

“…Substantial changes in SARS-CoV-2 prevalence with emergence of variants provides opportunity to investigate different methods to do this. …”

A systems biology approach to define SARS-CoV-2 correlates of protection in non-human primates by Brady, C

“…SARS-CoV-2 is expected to become a seasonal human coronavirus, with annual vaccination advised for vulnerable populations, similar to influenza. …”

Chronic neuropsychiatric sequelae of SARS-CoV-2: protocol and methods from the Alzheimer's Association Global Consortium by de Erausquin, GA, Snyder, H, Brugha, TS, Newton, C

“…No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). …”

Flood inundation mapping in the Kelantan River Basin, Malaysia, using Sentinel-1 SAR and Google Earth Engine by Yi, Lin Tew, Mou, Leong Tan, Liew, Juneng, Sazali Osman, Mohamad Hafiz Hassan, Narimah Samat, Chun, Kiat Chang, Li, Longhui

“…In this study, GEE was utilized to generate flood inundation maps for the Kelantan River Basin (KRB) using Sentinel-1 SAR data. Site inspections and Sentinel-2 Multispectral Instrument (MSI) satellite images of the actual flood regions were then used to validate the flood inundation maps. …”
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Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility by Cheng, Hui Mei, Zhao, Xiahong, Lim, Wei Shyann, Tan, Beatrice Jia Min, Tey, Hong Liang

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Cooperativity and induced oligomerization control the interaction of SARS-CoV-2 with its cellular receptor and patient-derived antibodies by Asor, R, Olerinyova, A, Burnap, SA, Kushwah, MS, Hensen, M, Vasiljevic, S, Chang, L, Dejnirattisa, W, Supasa, P, Stuart, DI, Screaton, GR, Zitzmann, N, Benesch, JLP, Struwe, WB, Kukura, P

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections by Rosenheim, J, Gupta, RK, Thakker, C, Mann, T, Bell, LCK, Broderick, CM, Madon, K, Papargyris, L, Dayananda, P, Kwok, AJ, Greenan-Barrett, J, Wagstaffe, HR, Conibear, E, Fenn, J, Hakki, S, Lindeboom, RGH, Dratva, LM, Lemetais, B, Weight, CM, Venturini, C, Kaforou, M, Levin, M, Kalinova, M, Mann, AJ, Knight, JC

“…We use high frequency sampling in the SARS-CoV-2 human challenge model to show induction of IFN-stimulated gene (ISG) expression with different temporal and cellular profiles. …”

Halal beauty supply chain and sustainable operational excellence: A moderator of the post-SARS-CoV-2 mitigation strategy by Fernando, Yudi, Mergeresa, Fineke, Ika Sari, Wahyuni-TD, Nurul Sabrina, Hazarasim

“…The second objective is to investigate Post-SARS-CoV-2 mitigation strategies executed by halal beauty companies in Malaysia. …”
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Enhanced cholesterol-dependent hemifusion by internal fusion peptide 1 of SARS Coronavirus-2 compared to its N-terminal counterpart by Pattnaik, Gourab Prasad, Bhattacharjya, Surajit, Chakraborty, Hirak

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A 98.6 dB SNDR SAR ADC with a mismatch error shaping technique implemented with double sampling by Yang, Chuanshi, Qiu, Lei, Tang, Kai, Zheng, Yuanjin

“…A novel mismatch error shaping (MES) method is proposed in noise-shaping (NS) SAR ADCs to break the SNDR limitation caused by DAC mismatch induced non-linearity. …”
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High-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner by Correa, Yubexi, Del Giudice, Rita, Waldie, Sarah, Thépaut, Michel, Micciula, Samantha, Gerelli, Yuri, Moulin, Martine, Delaunay, Clara, Fieschi, Franck, Pichler, Harald, Haertlein, Michael, Forsyth, V. Trevor, Le Brun, Anton, Moir, Michael, Russell, Robert A., Darwish, Tamim, Brinck, Jonas, Wodaje, Tigist, Jansen, Martin, Martín, César, Roosen-Runge, Felix, Cárdenas, Marité

“…There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). …”
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Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein by Loh, Jia Tong, Teo, Joey Kay Hui, Lam, Kong-Peng

“…However, the precise mechanism controlling calprotectin production during SARS-CoV-2 infection remains elusive. In this study, we showed that Dok3 adaptor restrains calprotectin production by neutrophils in response to SARS-CoV-2 spike (S) protein engagement of TLR4. …”
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The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2 by Nuccetelli, V, Mghezzi-Habellah, M, Deymier, S, Roisin, A, Gérard-Baraggia, F, Rocchi, C, Coureux, P, Gouet, P, Cimarelli, A, Mocquet, V, Fiorini, F

“…These results unveil a novel, multi-faceted mechanism by which SARS-CoV-2 evades the host’s defenses and manipulates cellular components. …”

COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection by Mahyuddin, Aniza P., Swa, Hannah L. F., Weng, Ruifen, Zhang, Jingxian, Dhanaraj, Janice P., Sesurajan, Binny P., Rauff, Mary, Dashraath, Pradip, Kanneganti, Abhiram, Lee, Rachel, Wang, Lin-Fa, Young, Barnaby Edward, Tambyah, Paul A., Lye, David C., Chai, Louis Y. A., Yee, Sidney, Choolani, Mahesh, Mattar, Citra N. Z.

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Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses by Scheim, David E., Parry, Peter I., Rabbolini, David J., Aldous, Colleen, Yagisawa, Morimasa, Clancy, Robert, Borody, Thomas J., Hoy, Wendy E.

“…Notably, the two human betacoronaviruses that express a sialic acid-cleaving enzyme are benign, while the other three&mdash;SARS, SARS-CoV-2 and MERS&mdash;are virulent. RBC aggregation experimentally induced in several animal species using an injected polysaccharide caused most of the same morbidities of severe COVID-19. …”
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Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

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A 9.87 nW 1 kS/s 8.7 ENOB SAR ADC for implantable epileptic seizure detection microsystems by Do, Anh Tuan, Lam, Chun Kit, Tan, Yung Sern, Yeo, Kiat Seng, Cheong, Jia Hao, Yao, Lei, Tan, Meng Tong, Je, Minkyu

“…This paper presents an ultra low-power SAR ADC in 0.18 μm CMOS technology for epileptic seizure detection applications. …”
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Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…We demonstrated that the production of SARS-CoV-2 VLPs using this cell pool was scalable up to a stirred-tank 2 L bioreactor in fed-batch mode. …”
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Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain by Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D, Nussenzweig, Michel C, Chakraborty, Arup K

“…The Omicron variant of SARS-CoV-2 is not effectively neutralized by most antibodies elicited by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing antibodies. …”
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