The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme by Monahan, KJ, Ryan, N, Monje-Garcia, L, Armstrong, R, Church, DN, Cook, J, Elghobashy, A, Lalloo, F, Lane, S, McDermott, FD, Miles, T, Hardy, SA, Tyson, A, Wang, VYW, Kim, A, Gelinas, S, Faravelli, F, Elmslie, F, Shaw, AC

“…Significant quality improvement has been implemented, facilitating systematic delivery of universal testing for LS nationally and reduction in variation in care.…”

Strategic and operational issues in sustaining community-based dementia support groups: the Get Real with Meeting Centres realist evaluation part 2 by Morton, T, Evans, SB, Swift, R, Bray, J, Frost, F, Russell, C, Brooker, D, Wong, G, Hullah, N

“…MCs need to be vigilant in mitigating pressures that create ‘mission drift’, as targeting a gap in the care pathway and maintaining a person-centred ethos are central to MCs’ appeal. …”

Autoimmune encephalitis by Irani, SR

“…The clinical-serologic picture guides the immunotherapy regime and offers valuable prognostic information. Patient care should be delivered in conjunction with autoimmune encephalitis experts.…”

Associations of treatment with hypnotics with suicide and attempted suicide: A nationwide cohort study by Høier, NK, Madsen, T, Spira, AP, Hawton, K, Jennum, P, Nordentoft, M, Erlangsen, A

“…</p> <p><strong>Conclusions::</strong> While confounding by indication is likely to be a major contributor, the fact that individuals in treatment with BZD or n-BZDs had higher rates of suicide and suicide attempts when compared to those not in treatment emphasizes the need to carefully monitor their mental state.</p>…”

The Pandemic EVIDENCE Collaboration Pillar 2: interventions and evidence by Fretheim, A, Onakpoya, I, Bartoszko, J, Jones, M, Gandini, S

“…Furthermore, the widespread nosocomial transmission in hospitals and long-term care homes and its devastating effects on the elderly require a better understanding of the role of the built environment as a risk factor. …”

Use of intravenous immunoglobulin for the treatment of autoimmune encephalitis: audit of the NHS experience by Kinsella, JA, Irani, SR, Hollingsworth, R, O’Shaughnessy, D, Kane, P, Foster, M, Schott, JM, Lunn, MP

“…</p> <p><strong>Setting</strong> NHS England Database of intravenous immunoglobulin use which covers secondary and tertiary care prescribing and use of intravenous immunoglobulin for all patients in hospitals in England.…”

The role of circulating tumor DNA in melanomas of the uveal tract by Zameer, MZ, Jou, E, Middleton, M

“…Recently, advances in minimally-invasive liquid biopsy techniques and biomarkers such as circulating tumor DNA (ctDNA) have demonstrated potential to transform the field of cancer care by aiding diagnosis, prognosis and monitoring of various cancer types. …”

Laboratory study of the enhanced wave-induced drift of large rectangular floating objects by Xiao, Q, McAllister, ML, Adcock, TAA, van den Bremer, T

“…This study presents laboratory experiments investigating the drift of large two-dimensional floating objects on deep-water, unidirectional, regular waves, with wave steepness ranging from 0.04 to 0.31 (0.04 < kaw < 0.31, where k is the wavenumber and aw the wave amplitude). The objects were carefully designed to have a rectangular cross-section with a constant aspect ratio; their size varied from 2.6% to 27% of the incident wavelength. …”

Methodology research in clinical studies for Neglected Tropical Diseases (NTDs) of the skin: Addressing design, conduct and relevance for context and target population by Erber, A

“…</p> <p>The first is a study evaluating a diagnostic test for BU at a point-of-care (PoC) setting in rural Ghana, complemented by interviews and focus group discussions (FGDs) with relevant stakeholders. …”

How ready is general practice to improve quality in chronic kidney disease? A diagnostic analysis by Crinson, I, Gallagher, H, Thomas, N, de Lusignan, S

“…Interventions in primary care, particularly the lowering of blood pressure in individuals with CKD and proteinuria and diabetes, can slow disease progression. …”

General practice antibiotic prescriptions attributable to respiratory syncytial virus by age and antibiotic class: an ecological analysis of the English population by Miller, L, Beaney, T, Hope, R, Cunningham, M, Robotham, J, Pouwels, K, Costelloe, CE

“…<p><strong>Background </strong></p> Respiratory syncytial virus (RSV) may contribute to a substantial volume of antibiotic prescriptions in primary care. However, data on the type of antibiotics prescribed for such infections is only available for children &lt;5 years in the UK. …”

Enteral and parenteral nutrition in patients with cancer: complication rates compared—updated systematic review and meta-analysis by Chow, R, Im, JHB, Arends, J, Del Fabbro, E, Mortensen-Truscott, L, Qeska, D, Balaji, S, Walsh, C, Watson, G, Lock, M, Prsic, E, Eng, L, Zimmermann, C, Bruera, E

“…Subgroup analysis found no differences in effects among patients with (vs without) PEM and patients provided with EN options of standard care versus TF. Discussion: From the perspective of complications, EN and PN are equivalent, with EN demonstrating marginal superiority for infection among adults.…”

Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania by Mshamu, S, Meta, J, Adhikari, B, Halifa, S, Mmbando, A, Wood, HS, Wood, OS, Bøjstrup, TC, Day, NPJ, Lindsay, SW, Knudsen, J, Deen, J, Seidlein, LV, Pell, C

“…Conclusions: The findings highlight the need for close attention to the use of novel design houses and careful sensitization around the potential benefits of dwellings to ensure that the intended health impacts of interventions are achieved.…”

Risk factors for PTSD symptoms following PICU admission for childhood septic shock by Corbet Burcher, GJ, O’Dea, LA, Cooper, MK, Lancaster, R, McCutcheon, RA, Garralda, ME, Nadel, S

“…Objective Paediatric intensive care unit (PICU) admission represents a traumatic event for many children. …”

External validation of the QCovid 2 and 3 risk prediction algorithms for risk of COVID-19 hospitalisation and mortality in adults: a national cohort study in Scotland by Kerr, S, Millington, T, Rudan, I, McCowan, C, Tibble, H, Jeffrey, K, Fagbamigbe, AF, Simpson, CR, Robertson, C, Hippisley-Cox, J, Sheikh, A

“…</p> <p><strong>Methods:</strong> We used the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 national data platform consisting of individual-level data for the population of Scotland (5.4 million residents). Primary care data were linked to reverse-transcription PCR virology testing, hospitalisation and mortality data. …”

Black democrats in white America: racial campaign strategies in majority-white contexts, 1989-2013 by Johnson, R

“…Commentators continue to argue that successful black candidates must discard their racial identity in order to win white votes, yet a careful examination of the actual practices of black politicians in majority-white jurisdictions demonstrates that this argument is not substantiated empirically. …”

Feasibility of an undergraduate academic fellowship in global health system development by Pine, H, Mayoras, BR, Klapow, MC, Smith, NJ, Delaney, PG, Eisner, ZJ

“…Methods: Lay First Responders (LFR) International’s Fellowship Program in Emergency Medical Care and Innovation (ECMI) trains undergraduates to develop community-based emergency medical services in low- and middle-income countries, focusing on global capacity building, service leadership, and cultural competency. …”

Contextualising the contrafacta of trouvere song by Quinlan, M

“…</p> <p>The case studies reveal a culture that cared about melodic association and used it in sophisticated ways. …”

Cultivating participatory processes in self-harm app development: a case-study and working methodology by Babbage, CM, Lockwood, J, Roberts, L, Mendes, J, Greenhalgh, C, Willingham, L-P, Wokomah, E, Woodcock, R, Slovak, P, Townsend, E

“…The codevelopment of a digital, clinical tool which meets the needs of multiple stakeholders requires careful consideration.</p> <p><strong>Methods:&nbsp;</strong>We present a case-study describing the participatory aspects of the development of the CaTS-App, which included comprehensive patient involvement, research activities and coproduction with diverse young people aged 17&ndash;24 with lived experience of self-harm. …”

A feline model of spontaneously occurring autoimmune limbic encephalitis by Glantschnigg-Eisl, U, Klang, A, Kneissl, S, Lang, B, Waters, P, Irani, SR, Binks, SNM, Pakozdy, A

“…Although six cats were euthanased in the first year for epilepsy-associated reasons, those attaining at least 1-year survival had good seizure control and quality of life with appropriate veterinary care and medication. Acute-phase immunotherapy (prednisolone) was given to the most severely unwell cases and its effect is retrospectively evaluated in 10 cats. …”