Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies by Hunter, B, Li, M, Parker, BL, Koay, YC, Harney, DJ, Pearson, E, Cao, J, Chen, GT, Guneratne, O, Smyth, GK, Larance, M, O’Sullivan, JF, Lal, S

“…Inter-ventricular significance of these metabolic pathways was then found to be diminished within end-stage dilated cardiomyopathy and ischaemic cardiomyopathy, while heart failure-associated pathways were increased in the left ventricle relative to the right within ischaemic cardiomyopathy, such as fluid sheer-stress, increased glutamine-glutamate ratio, and down-regulation of contractile proteins, indicating a left ventricular pathological bias.…”

Large scale paired antibody language models by Kenlay, H, Dreyer, FA, Kovaltsuk, A, Miketa, D, Pires, D, Deane, CM

“…With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in the design of better therapeutics has been constrained by the sheer volume and complexity of the data. To address this challenge, we present IgBert and IgT5, the best performing antibody-specific language models developed to date which can consistently handle both paired and unpaired variable region sequences as input. …”

Quality over quantity: powering neuroimaging samples in psychiatry by Makowski, C, Nichols, TE, Dale, AM

“…In this review, we encourage this discourse to shift from a focus on sheer increases in sample size to more thoughtful choices surrounding experimental study designs. …”

Regression analysis ofr characterization of materials for photovoltaic cells by Vundavalli, Bala Satya Manikanta

“…The traditional Design-of-Experiments (DoEs) adapted so far, are slow and the information obtained sometimes bears little relevance to optimizing the key performance parameters of merit. …”
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Ancient Art, Modern Tech: Experiencing the Digital Reinvention of the Mogao Grottoes by Zhao, Celina

“…But now it must confront the greatest challenge to its continued existence: modern-day tourism. The sheer volume of visitors seeking a direct experience of this unique but delicate site has resulted in an increasingly rapid process of destruction in the 21st century. …”
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A highly strained Al-Al σ-bond in dianionic aluminum analog of oxirane for molecule activation by Koshino, Kota, Kinjo, Rei

“…Since aluminum is the most electropositive element among the p-block elements, the construction of molecules bearing a dianionic Al-Al σ-bond is inherently highly challenging. …”
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Wind tunnel design and fabrication for lift force investigation by Kong, Shao Ming

“…As wind tunnels are resource intensive equipment, its potential as a learning aid is greatly hampered due to the sheer cost and logistics involved in the operation of a full sized wind tunnel. …”
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Ig.n.is. by Ong, Jian'an.

“…This spectrum does not appear suddenly, nor was it by sheer chance. There is a cascading effect on successive development of thought and spirituality that led to where we are, who we are, and why do we behave the way we do.…”
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Aggregating and analyzing Indian political tweets by Chirag Ruhela

“…Understanding this huge data-set in its raw form is not possible due to the sheer dimensionality of the data-set. Thus dimensionality reduction and clever insightful visualizations are needed to make this data consumable for general public. …”
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Carbon-semiconductor hybrid nanostructures and their photoresponse behaviors by Zhan, Zhaoyao

“…Carbon nanomaterials are unique in terms of structure, carbon nanotube (CNT) bears a hollow one-dimensional structure; and graphene is an one-atom-thick sheet and has extremely high specific surface area; both of them are presenting excellent charge transport capability. …”
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Edge/cloud resource management for time-sensitive applications by Lim, Her Huey

“…Technological advancements and skyrocketing interest in areas such as Artificial Intelligence and Internet of Things as well as the sheer increase in development of software solutions, tools, infrastructure, and more have driven demand for cloud resources to staggering heights. …”
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SyROCCo: enhancing systematic reviews using machine learning by Fang, Z, Arana-Catania, M, van Lier, F-A, Outes Velarde, J, Bregazzi, H, Airoldi, M, Carter, E, Proctor, R

“…The sheer number of research outputs published every year makes systematic reviewing increasingly time- and resource-intensive. …”

Ozone reaction with interior building materials: Influence of diurnal ozone variation, temperature and humidity by Rim, Donghyun, Maddalena, Randy L., Nazaroff, William W., Gall, Elliott Tyler

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Material extrusion-based printing optimization of recycled HDPE filaments made from used milk jugs by Teng, Phillis Soek Po, Tee, Chor Hiong, Tan, Hwee Boon, Leong, Kah Fai

“…High-density polyethylene (HDPE) is a widely used thermoplastic material for product packaging. The sheer availability of recyclable or recycled HDPE (rHDPE) from used packaging has led to efforts to apply it in MEX printing. …”
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HIV decision support : from molecule to man by Sloot, Peter M. A., Coveney, P. V., Muller, V., Boucher, Charles A. B., Ertaylan, Gokhan, Bubak, Marian

“…Effective highly active antiretroviral therapy and the availability of genetic screening of patient virus data have led to sustained viral suppression and higher life expectancy in patients who have been infected with HIV. The sheer complexity of the disease stems from the multiscale and highly dynamic nature of the system under study. …”
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Linear A libation tables : a semitic connection explored by Eu Min, Niki Cassandra, Perono Cacciafoco, Francesco, Cavallaro, Francesco Paolo

“…Unlike the Linear B language (Mycenaean Greek), Minoan, the language hidden behind Linear A and still undeciphered, bears no apparent similarity to Greek, and any ‘translation’ of Linear A based provisionally on Linear B phonetic values has not produced any tangible result. …”
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Creating functionally graded concrete materials with varying 3D printing parameters by Tay, Daniel Yi Wei, Lim, Jian Hui, Li, Mingyang, Tan, Ming Jen

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Secure image encryption based on an ideal new nonlinear discrete dynamical system by Lin, M. Rongming, Ng, Teng Yong

“…Extensive numerical experiment results have revealed that the proposed image encryption algorithm offers advantages of unlimited key space and high-level security, since those problematic periodic windows are no longer present within the key space, and it is extremely robust against known-plain-text attack, since the chaotic sequence generated bears no correlation whatsoever due to the folding effect of modulo operation. …”
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A perspective on the role of point-of-care "immuno-triaging" to optimize COVID-19 vaccination distribution in a time of scarcity by Zhang, Yi, Rogers, Angela, Nadeau, Kari, Gu, Jun, Yang, Samuel

“…Vaccine bears hope to bring COVID-19 pandemic under control. …”
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Functional genetics of cancer and congenital disorders by Zak, J

“…An integrative analysis of cancer genomic data revealed that <em>PPP1R13B</em>, encoding ASPP1, bears many hallmarks of a tumour suppressor gene, despite being mutated at a low absolute frequency. …”