Hypoxia inhibits MHC I expression and antigen presentation to escape immune surveillance by Estephan, H, Tailor, A, Parker, R, Kreamer, M, Papandreou, I, Campo, L, Easton, A, Moon, EJ, Denko, N, Ternette, N, Hammond, E, Giaccia, A

“…In experimental tumors, reducing mitochondrial metabolism through a complex I inhibitor increases tumor oxygenation and both MHC I levels as well as the immunopeptidome. …”

Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria by Gargiulo, L, Papaioannou, M, Sica, M, Talini, G, Chaidos, A, Richichi, B, Nikolaev, AV, Nativi, C, Layton, M, de la Fuente, J, Roberts, I, Luzzatto, L, Notaro, R, Karadimitris, A

“…These T cells were significantly more abundant in PNH patients than in healthy controls; their reactivity depended on CD1d expression and they increased upon coculture with CD1d-expressing, GPI-positive APCs. …”

YAP-DKK1 axis restricts regeneration to the isthmus of the human gastric glands by Zagami, C

Subjects: “…This thesis postulates that YAP-DKK1 interaction restricts regenerative cellular activity to the isthmus of the stomach gastric gland, by inhibiting Wnt/β-catenin signalling pathway.…”

A structure-function study of the TWIK-1 K2P channel by Abd-Wahab, MF

“…<p>Two-pore domain potassium (K2P) channels play a role in regulating the resting mem- brane potential of cells and therefore play a major role in the function of both excitable and non-excitable cells. One of the K2P family members is the Tandem-pore Weak Inwardly-rectifying Potassium (TWIK-1) channel. …”

Characterising the functional role of GATA1short isoform in normal and malignant haematopoiesis by Cruz Hernandez, D

“…I showed biding of GATA1s at the -77kb enhancer of GATA2 in an ML-DS derived cell line. …”

Hunting the origin and source of NR1-directed IgGs in patients with encephalitis by Cleaver, J, Dale, R, Irani, SR

The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Pounds, R, Croft, W, Pearce, H, Hossain, T, Singh, K, Balega, J, Jeevan, DN, Sundar, S, Kehoe, S, Yap, J, Moss, P, Zuo, J

“…Expression of PVR, the DNAM-1 ligand, was significantly increased on tumours and DNAM-1 mediated NK cell lysis of primary tumour tissue was observed in vitro. …”

Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1 by Ramirez-Franco, J, Debreux, K, Extremet, J, Maulet, Y, Belghazi, M, Villard, C, Sangiardi, M, Youssouf, F, El Far, L, Lévêque, C, Debarnot, C, Marchot, P, Paneva, S, Debanne, D, Russier, M, Seagar, M, Irani, SR, El Far, O

“…Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. …”

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Raj Murthi, S, Petry, A, Shashikadze, B, Stöckl, JB, Schmid, M, Santamaria, G, Klingel, K, Kračun, D, Chen, X, Bauer, S, Schmitt, JP, Flenkenthaler, F, Gorham, J, Toepfer, CN, Potěšil, D, Hruška, P, Zdráhal, Z, Mayer, Z, Klop, M, Lehmann, L, Qin, Y, Papanakli, L, Spielmann, N, Moretti, A

“…Hypoxia-inducible transcription factor-1α (Hif-1α) is the central master regulators of cellular hypoxia response and associated with HCM. …”

Investigating the role of lysine demethylase UTX-1 in lifespan regulation of C. elegans by Guillermo, A

“…Overexpression and downregulation of <p>utx-1</p> (H3K27me2/3-specific lysine demethylase UTX-1) was found to promote lifespan extension in <em>C. elegans</em>. …”

Immunotherapy responsive neuropathic pain associated with LGI1 and CASPR2 antibodies by Ramanathan, S, Davies, A, Uy, C, Tseng, M, Paneva, S, Michael, S, Varley, J, Binks, S, Themistocleous, A, Anziska, Y, Candalija, A, Soni, A, Hofer, M, Brilot, F, Dale, RC, Dawes, J, Rinaldi, S, Bennett, D, Irani, SR

Optimization of in vitro regeneration protocol of tomato cv. MT1 for genetic transformation by Ahmed, Shiuli, Wan Azizan, Wan Aina Sakeenah, Akhond, Md. Abdullah Yousuf, Juraimi, Abdul Shukor, Ismail, Siti Izera, Ahmed, Razu, Md Hatta, Muhammad Asyraf

“…The present study was conducted to optimize the in vitro regeneration protocol for the tomato cv. MT1. The regeneration capacity of hypocotyl and cotyledon explants was evaluated using a total of 20 concentration combinations of two plant growth regulators (PGRs) added into the basal MSB5 medium, namely, 6-benzylaminopurine (BAP) (0, 1, 2, 3, and 4 mg/L) and indole-3-acetic acid (IAA) (0, 0.05, 0.1, and 0.5 mg/L). …”
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Ambulatory measurement of 3-dimensional foot displacement during treadmill walking using wearable wireless ultrasonic sensor network by Qi, Yongbin, Soh, Cheong Boon, Gunawan, Erry, Low, Kay-Soon

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