An evidence-based serious game app for public education on antibiotic use and resistance: randomized controlled trial by Huang, Zhilian, Ow, Jing Teng, Tang, Wern Ee, Chow, Angela

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Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial by Panday, Rishi Nannan, Wang, S., Schermer, E. H., Cooksley, T., Alam, N., Nanayakkara, P. W. B.

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A randomized waitlist-controlled trial of an intergenerational arts and heritage-based intervention in Singapore: project ARTISAN by Ho, Andy Hau Yan, Ma, Stephanie Hilary Xinyi, Tan, Michael Koon Boon, Bajpai, Ram Chandra

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Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation by Mellado-Artigas, Ricard, Borrat, Xavier, Ferreyro, Bruno L., Yarnell, Christopher, Hao, Sicheng, Wanis, Kerollos N., Barbeta, Enric, Torres, Antoni, Ferrando, Carlos, Brochard, Laurent

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A systematic review and network meta-analysis of randomized controlled trials on choice of central venous access device for delivery of chemotherapy by Yeow, Marcus, Soh, Shauna, Yap, Ryan, Tay, Desiree, Low, Yi Fen, Goh, Serene Si Ning, Yeo, Charleen Shanwen, Lo, Joseph Zhiwen

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The Impact of Large-Scale Social Media Advertising Campaigns on COVID-19 Vaccination: Evidence from Two Randomized Controlled Trials by Ho, Lisa, Breza, Emily, Banerjee, Abhijit, Chandrasekhar, Arun G., Stanford, Fatima C., Fior, Renato, Goldsmith-Pinkham, Paul, Holland, Kelly, Hoppe, Emily, Jean, Louis-Maël, Ogbu-Nwobodo, Lucy, Olken, Benjamin A., Torres, Carlos, Vautrey, Pierre-Luc, Warner, Erica, Duflo, Esther, Alsan, Marcella

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Monitoring of singlet fission via two-dimensional photon-echo and transient-absorption spectroscopy : simulations by multiple Davydov trial states by Sun, Kewei, Huang, Zhongkai, Gelin, Maxim F., Chen, Lipeng, Zhao, Yang

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Comparison and modeling of leachate transportation dominated by the field permeability with an anisotropic characteristic based on a large-scale field trial study by Yin, Ke, Chan, Wei Ping, Dou, Xiaomin, Lisak, Grzegorz, Chang, Victor Wei-Chung

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Time to speed up scientific deliveries in fibrotic interstitial lung disease: innovative clinical trial design to improve patient care by Kawano-Dourado, L, Kulkarni, T, Ryerson, CJ, Richards, DB

Filipino multicomponent intervention to maintain cognitive performance in high-risk population (FINOMAIN): study protocol for a cluster randomized controlled trial by Dominguez, Jacqueline, De Guzman, Ma Fe, Chen, Annabel Shen-Hsing, Sano, Mary, Waldemar, Gunhild, Phung, Thien Kieu Thi

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Supporting insulin initiation in type 2 diabetes in primary care: results of the Stepping Up pragmatic cluster randomised controlled clinical trial by Furler, John, O’Neal, David, Speight, Jane, Manski-Nankervis, Jo-Anne, Gorelik, Alexandra, Holmes-Truscott, Elizabeth, Ginnivan, Louise, Young, Doris, Best, James, Patterson, Elizabeth, Liew, Danny, Segal, Leonie, May, Carl, Blackberry, Irene

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Impact of the HOPE intervention on mental health literacy, psychological well-being and stress levels amongst university undergraduates: a randomised controlled trial by Tay, Jing Ling, Goh, Yong Shian Shawn, Sim, Kang, Klainin-Yobas, Piyanee

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The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial by Cooper, Daniel J., Plewes, Katherine, Grigg, Matthew J., Rajahram, Giri S., Piera, Kim A., William, Timothy, Chatfield, Mark D., Yeo, Tsin Wen, Dondorp, Arjen M., Anstey, Nicholas M., Barber, Bridget E.

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Robotic assisted upper limb training post stroke : a randomized control trial using combinatory approach toward reducing workforce demands by Budhota, Aamani, Chua, Karen S. G., Hussain, Asif, Kager, Simone, Cherpin, Adèle, Contu, Sara, Vishwanath, Deshmukh, Kuah, Christopher W. K., Ng, Chwee Yin, Yam, Lester H. L., Loh, Yong Joo, Rajeswaran, Deshan Kumar, Xiang, Liming, Burdet, Etienne, Campolo, Domenico

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UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract by Stritt, Kevin, Roth, Beat, Masnada, Audrey, Hammann, Felix, Jacot, Damien, Domingos-Pereira, Sonia, Crettenand, François, Bohner, Perrine, Sommer, Isabelle, Bréat, Emilien, Sauser, Julien, Derré, Laurent, Haschke, Manuel, Collins, James J., McKinney, John

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Vertical distribution of heavy metals in seawater column during IBA construction in land reclamation – re-exploration of a large-scale field trial experiment by Yin, Ke, Chan, Wei-Ping, Dou, Xiaomin, Lisak, Grzegorz, Chang, Victor Wei-Chung

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Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT) : study protocol for an effectiveness-implementation hybrid ra... by Tan, Bryan Yijia, Pereira, Michelle Jessica, Yang, Su-Yin, Hunter, David J., Skou, Soren Thorgaard, Thumboo, Julian, Car, Josip

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Predicting cognitive scores from wearable-based digital physiological features using machine learning: data from a clinical trial in mild cognitive impairment by Rykov, Yuri G., Patterson, Michael D., Gangwar, Bikram A., Jabar, Syaheed B., Leonardo, Jacklyn, Ng, Kok Pin, Kandiah, Nagaendran

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Exposure therapy with personalized real-time arousal detection and feedback to alleviate social anxiety symptoms in an analogue adult sample : pilot proof-of-concept randomized con... by Lin, Bernice Xiangting, Lee, Tih-Shih, Cheung, Yin Bun, Ling, Joanna, Poon, Shi Hui, Lim, Leslie, Zhang, Hai Hong, Chin, Zheng Yang, Wang, Chuan Chu, Krishnan, Ranga, Guan, Cuntai

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Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial by Desmarets, M, Hoffmann, S, Vauchy, C, Rijnders, BJA, Toussirot, E, Durrbach, A, Körper, S, Schrezenmeier, E, van der Schoot, CE, Harvala, H, Brunotte, G, Appl, T, Seifried, E, Tiberghien, P, Bradshaw, D, Roberts, DJ, Estcourt, LJ, Schrezenmeier, H

“…A comprehensive number of clinical trials on CCP efficacy have already been conducted. …”