Gene expression regulation by well-known non-coding RNAs by Tan, Jiazi

“…In one project, we attempted to insert a second Xist gene into the single X chromosome of male murine embryonic stem (ES) cells to cause ectopic XCI upon differentiation, leading to cell lethality as important X-linked genes were inactivated. From there, we could screen for genes important for XCI by rescuing the differentiated transgenic ES cells by gene silencing. …”
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Robust cooperative control and optimization of multi-agent systems by Sun, Chao

“…Nodes connected with a positive edge can be viewed as “friends” and linked with a negative edge can be viewed as “enemies”. …”
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An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…Previous studies, including genome-wide association studies (GWAS), have identified genetic variants near the UGT2A1 and UGT2A2 genes that are linked to anosmia in COVID-19 patients. However, the role of epigenetic changes in the development and persistence of smell loss has not been well explored. …”
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Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…However, it was not known whether these functions are conserved in mammalian cells or if they are linked.</p> <p>To inform on OGFOD1-dependent cellular phenotypes, OGFOD1 defective cells were generated by genome editing using the CRISPR methodology. …”

Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: cohort study by Tsigebrhan, R, Medhin, G, Belina, M, Newton, C, Hanlon, C

“…Structural equation modelling (SEM) was employed to examine direct and indirect pathways linking co-morbid CMD symptoms with QoL or functional disability.…”

Joint modelling of longitudinal data: a scoping review of methodology and applications for non-time to event data by Ouko, RK, Mukaka, M, Ohuma, EO

“…The random effect was the most commonly applied association structure for linking two sub-models (63 studies; 85%). Estimation of model parameters was commonly done using Markov Chain Monte Carlo with Gibbs sampler algorithm (10 studies; 38%) for the Bayesian approach, whereas maximum likelihood was the most common (33 studies; 68.75%) for the frequentist approach. …”

Health economic aspects of childhood excess weight by Onyimadu, O

“…Additionally, electronic health records extracted from the Clinical Practice Research Datalink (CPRD), linked with Hospital Episode Statistics (HES), were analysed to estimate direct healthcare costs attributable to childhood excess weight.…”

Adverse events of common psychiatric medications: an umbrella review by Bartellas, K

“…Many medications were linked to adverse events through a weak or moderate strength of association and additional factors contributed to the variability in adverse outcome reporting aside from patient characteristics. …”

Human agency and instrumental rationality: applying human capital to gender inequalities and intergenerational stratification by Luo, H

“…</p></br> <p><strong>Contributions</strong></p> <p>Theoretically, this thesis contributes to linking human agency and instrumental rationality to the persistence and transformation of structural inequalities; it also sheds light on education’s potential and limitations as an equalizer. …”

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro,... by Yang, Z, Sheehan, AM, Messer, AE, Tsui, S, Sparrow, A, Redwood, C, Kren, V, Gould, IR, Marston, SB

“…Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca2+ associated with a higher rate of Ca2+ dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy). Cardiomyopathy-linked mutations primarily affect Ca2+ regulation or the PKA-dependent modulatory system, such that Ca2+-sensitivity becomes independent of phosphorylation level (uncoupling) and this could be sufficient to induce cardiomyopathy. …”

Enhancement of lentiviral vector production through alteration of virus-cell interactions by Gelinas, J

“…To support this aim, viruses have been modified, with elements linked to viral pathogenicity removed from their genome and replaced by the genetic material to be delivered. …”

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Setting: UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…The countermeasures are linked to phases of the overarching editorial workflow, to ensure that their implementation is feasible and that they are clearly useful by and for specific role categories within the media.…”

In-silico trials with human modelling and simulation for guiding optimal stratification of atrial fibrillation patients to catheter ablation and pharmacological therapy by Dasí i Martinez, A

“…Different mechanisms of the arrhythmia (i.e., stable micro-re-entries, wavefront meandering, transient rotors and wave breakups) have been linked to specific ionic current dysregulations and their relationship with the structurally-remodelled substrate (i.e., presence of low voltage areas and atrial enlargement).…”

Nonvolatile resistive switching in Pt/LaAlO3/SrTiO3 heterostructures by Wu, Shuxiang, Luo, Xin, Turner, Stuart, Peng, Haiyang, Lin, Weinan, Ding, Junfeng, David, Adrian, Wang, Biao, Van Tendeloo, Gustaaf, Wang, Junling, Wu, Tom

“…We propose that the observed resistive switching is likely caused by the electric-field-induced drift of charged oxygen vacancies across the LaAlO3/SrTiO3 interface and the creation of defect-induced gap states within the ultrathin LaAlO3 layer. …”
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EDTA-enhanced thermal washing of contaminated dredged marine sediments for heavy metal removal by Yin, Ke, Giannis, Apostolos, Wong, Angeline S. Y., Wang, Jing-Yuan

“…Sequencing processes of thermal treatment followed by EDTA washing showed limited performance, likely due to thermal stabilization of the contaminants particularly at low liquid-to-soil (L/S) ratio. …”
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A versatile light-switchable nanorod memory : Wurtzite ZnO on perovskite SrTiO3 by Bera, Ashok, Peng, Haiyang, Lourembam, James, Shen, Youde, Sun, Xiaowei, Wu, T.

“…The reversible modification of the effective interfacial energy barrier in the concurrent electronic and ionic processes most likely gives rise to the high susceptibility of the ZnO/NSTO heterojunction to external electric and optical stimuli. …”
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Review of the potential health effects of light and environmental exposures in underground workplaces by Khaing, Nang Ei Ei, Abuduxike, Gulifeiya, Posadzki, Pawel, Divakar, Ushashree, Visvalingam, Nanthini, Nazeha, Nuraini, Dunleavy, Gerard, Christopoulos, George I., Soh, Chee-Kiong, Jarbrink, Krister, Soljak, Michael, Car, Josip

“…There is a large but mainly observational research literature on likely underground exposures, including effects of artificial lighting, shift working and light at night on circadian disruptions and associated health effects. …”
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The Ayeyarwady River (Myanmar) : washload transport and its global role among rivers in the Anthropocene by Latrubesse, Edgardo M., Park, Edward, Kästner, Karl

“…We show that the Ayeyarwady has likely become the river with the second or third largest delivery of washload to the sea in the world since it has so far been much less affected by damming compared to the vast majority of other rivers.…”
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The devil is in the detail? Investors’ mispricing of proxy voting outcomes on M&A deals by Li, Lingwei, Zhang, Huai

“…What's more, the association between the voting outcome and post-merger stock returns is stronger when investors’ attention to the voting outcome is distracted by same-day earnings announcements, when the marginal investor is less likely to be sophisticated, and when investors have greater pre-merger disagreement. …”
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