When a test is more than just a test: findings from patient interviews and survey in the trial of a technology to measure antidepressant medication response (the PReDicT Trial) by Brown, S, Ploeger, C, Guo, B, Petersen, JJ, Beckenstrom, AC, Browning, M, Dawson, GR, Deckert, J, Dias, R, Dourish, CT, Gorwood, P, Kingslake, J, Menke, A, Sola, VP, Reif, A, Ruhe, H, Simon, J, Stäblein, M, van Schaik, A, Veltman, DJ, Morriss, R, PReDicT Group

“…The aim was to explore patient experiences of the Test including acceptability and implementation, to inform its use within care. A bespoke survey was completed by trial participants in five countries (n = 778) at week 8. …”

Adaptation of the WHO AWaRe (Access, Watch, Reserve) antibiotic classification to support national antimicrobial stewardship priorities in the UK: findings from a modified Delphi a... by Bou-Antoun, S, Oettle, RC, Leanord, A, Seaton, RA, Cooper, BS, Muller-Pebody, B, Conlon-Bingham, G, Kerr, F, Hand, KS, Sandoe, JAT, Llewelyn, MJ, Fleming, N, Brown, NM, Reid, N, Howard, P, Mckinstry, S, Malcolm, W, Demirjian, A, Ashiru-Oredope, D

“…We assessed the categorization of each of the antibiotics for systemic use for antimicrobial stewardship and quality improvement practice across primary and secondary care in the UK, proposing a nationally adapted UK-AWaRe classification. …”

Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets by Burchardt, JM, Mei, XW, Ranger, T, McDermott, CJ, Radunovic, A, Coupland, C, Hippisley-Cox, J

“…<p><strong>Conclusion</strong></p> The use of three linked national datasets captured 33% more people than a primary care dataset alone. Patients were older than in previous studies and rates were high in all ethnic groups studied except Black African and Chinese people. …”

‘An unimaginable challenge’: a cross-cultural qualitative study of ethics and decision-making around tracheostomy ventilation in patients with amyotrophic lateral sclerosis by Ozeki-Hayashi, R, Wilkinson, D

“…<p><strong> Conclusions</strong></p> Our study illustrates how the emphasis on autonomy varies along with variations in the way care is organized in the setting of highly resource intensive treatment and progressive severe disabling illness. …”

Omega-3 fatty acid supply in pregnancy for risk reduction of preterm and early preterm birth by Cetin, I, Carlson, SE, Burden, C, da Fonseca, EB, di Renzo, GC, Hadjipanayis, A, Harris, WS, Kumar, KR, Olsen, SF, Mader, MS, McAuliffe, FM, Muhlhausler, B, Oken, E, Poon, LC, Poston, L, Ramakrishnan, U, Roehr, CC, Savona-Ventura, C, Smuts, CM, Sotiriadis, A, Su, K-P, Tribe, RM, Vannice, G, Koletzko, B, Clinical Practice Guideline

External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland by Simpson, CR, Robertson, C, Kerr, S, Shi, T, Vasileiou, E, Moore, E, McCowan, C, Agrawal, U, Docherty, A, Mulholland, R, Murray, J, Ritchie, LD, McMenamin, J, Hippisley-Cox, J, Sheikh, A

“…<p><strong>Methods</strong></p> We established a national COVID-19 data platform using individual level data for the population of Scotland (5.4 million residents). Primary care data were linked to reverse-transcription PCR (RT-PCR) virology testing, hospitalisation and mortality data. …”

Medical management pathways for Cushing’s disease in pituitary tumors centers of excellence (PTCOEs) by Giustina, A, Uygur, MM, Frara, S, Barkan, A, Biermasz, NR, Chanson, P, Freda, P, Gadelha, M, Haberbosch, L, Kaiser, UB, Lamberts, S, Laws, E, Nachtigall, LB, Popovic, V, Schilbach, K, Lely, AJVD, Wass, JAH, Melmed, S, Casanueva, FF

“…This study aimed to evaluate current medical therapy approaches by expert pituitary centers through an audit conducted to validate the criteria of Pituitary Tumors Centers of Excellence (PTCOEs) and provide an initial standard of medical care for CD. Methods: Based on the activities of nine international PTCOEs between 2018 and 2020, we evaluated patients under medical treatment and their biochemical control rates. …”

Rocking the boat: maritime humanitarianism and responses to displacement at sea, 1978-2022 by Dobie, IR

“…I argue that their ‘rebellions’ stem from the specific operational frictions that arise at sea, where care is provided on the move beyond territorial borders. …”

Effectiveness and safety of COVID-19 vaccination in people with blood cancer by Copland, E, Hirst, J, Mi, E, Patone, M, Chen, D, Coupland, C, Hippisley-Cox, J

“…</p> <br> <p><strong>Methods:</strong> Individuals aged ≥12 years as of 1st December 2020 in the QResearch primary care database were included. We assessed adjusted COVID-19 vaccine effectiveness (aVE) against COVID-19-related hospitalisation and death in people with blood cancer using a nested matched case-control study. …”

Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method by Thwaites, L, Nasa, P, Abbenbroek, B, Dat, VQ, Finfer, S, Kwizera, A, Ling, L, Lobo, SM, Sinto, R, Aditianingsih, D, Antonelli, M, Arabi, YM, Argent, A, Azevedo, L, Bennett, E, Chakrabarti, A, De Asis, K, De Waele, J, Divatia, JV, Estenssoro, E, Evans, L, Faiz, A, Hammond, NE, Hashmi, M

“…These include consensus on managing patients with sepsis outside a designated critical care area, triggers for escalating clinical management and criteria for safe transfer to another facility. …”

Effective dietary interventions during pregnancy: a systematic review and meta-analysis of behavior change techniques to promote healthy eating by O’Connor, H, Meloncelli, N, Wilkinson, SA, Scott, AM, Vincze, L, Rushton, A, Dawson, S, Hollis, J, Whiteoak, B, Gauci, S, de Jersey, S

“…Six databases were searched to identify randomised control trials (RCTs) reporting on dietary intake in pregnant women over the age of sixteen, with an active intervention group compared to a control group receiving usual care or less intensive interventions. The Cochrane Risk of Bias Tool 1 was used to assess study validity. …”

Multicenter diagnostic evaluation of onsite COVID-19 Rapid Test (CTK Biotech) among symptomatic individuals in Brazil and the United Kingdom by Thompson, CR, Torres, PM, Kontogianni, K, Byrne, RL, LSTM Diagnostic group, Noguera, SV, Luna-Muschi, A, Marchi, AP, Andrade, PS, Dos Santos Barboza, A, Nishikawara, M, CONDOR steering group, Body, R, de Vos, M, Escadafal, C, Adams, E, Figueiredo Costa, S, Cubas-Atienzar, AI

“…A total of 496 paired nasopharyngeal (NP) swabs were collected from symptomatic health care workers at Hospital das Clínicas in São Paulo, Brazil, and 211 NP swabs were collected from symptomatic participants at a COVID-19 drive-through testing site in Liverpool, United Kingdom. …”

Τhe burial rite of Enchytrismos in Attica, Euboea and Boeotia during the Late Geometric and Archaic periods. Towards an understanding of its social significance by Vlanti, AD

“…</p> <p>The systematic examination which has been undertaken clearly demonstrates that the rite of enchytrismos was a time-consuming and carefully thought social act that placed particular emphasis on the protection and preservation of the dead body. …”

Differences between neonatal units with high and low rates of breast milk feeding for very preterm babies at discharge: a qualitative study of staff experiences by McLeish, J, Aloysius, A, Gale, C, Quigley, M, Kurinczuk, JJ, Alderdice, F

“…Conclusions: Effective support can be influenced by having a supernumerary post dedicated to infant feeding; strong leadership that champions breast milk feeding and breastfeeding within Family Integrated Care; maintaining accountability by using existing quality improvement tools and accredited standards for neonatal units; and training for the whole multi-disciplinary team that encourages and enables every member of staff to take an appropriate share of responsibility for consistently informing and assisting mothers with expressing and breastfeeding. …”

Understanding the lived experiences of people living with epilepsy: oral history assessment in the Shai Osudoku and Ningo Prampram districts, Ghana by Asiamah, S, Gyeke, PD, Darkwa, EK, Mahone, S, Williams, J, Akpalu, A, Newton, CR, Sottie, C, Adjei, P

“…These healers provide care by offering prayers, spiritual counselling, and incorporating various religious rituals into their healing practices. …”

Interventions for prevention and treatment of trastuzumab-induced cardiotoxicity: an umbrella review of systematic reviews and meta-analyses by Wang, Y, Xu, J, Xie, Y, Zhou, D, Guo, M, Qin, Y, Yi, K, Tian, J, You, T

“…Conclusion: Evidence strongly supports the systematic implementation of cardioprotective strategies in clinical practice, particularly statins and beta-blockers, as part of routine care protocols for patients receiving trastuzumab therapy. …”

Enhancing trauma triage in low-resource settings using machine learning: a performance comparison with the Kampala Trauma Score by Nsubuga, M, Kintu, TM, Please, H, Stewart, K, Navarro, SM

“…These findings suggest a promising opportunity to advance trauma care in LMICs by integrating ML into triage decision-making. …”

RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease by Lentzen, M, Vairavan, S, Muurling, M, Alepopoulos, V, Atreya, A, Boada, M, de Boer, C, Conde, P, Curcic, J, Frisoni, G, Galluzzi, S, Gjestsen, MT, Gkioka, M, Grammatikopoulou, M, Hausner, L, Hinds, C, Lazarou, I, de Mendonça, A, Nikolopoulos, S, Religa, D, Scebba, G, Jelle Visser, P, Wittenberg, G, Narayan, V

“…Timely detection of these symptoms can facilitate early intervention, potentially slowing disease progression and enabling appropriate treatment and care. Methods: The RADAR-AD study was designed to evaluate the accuracy and validity of multiple RMTs in detecting functional decline across various stages of AD in a real-world setting, compared to standard clinical rating scales. …”

Understanding health system responsiveness to public feedback at the sub-national level: Insights from Kilifi County, Kenya by Kagwanja, N, Gilson, L, Tsofa, B, Olivier, J, Leli, H, Molyneux, S

“…SCHMTs comprise middle-level managers with oversight over primary health care facilities and are commonly known as district health management teams in other LMICs. …”

Evaluation and implementation of a Just-In-Time bed-assignment strategy to reduce wait times for surgical inpatients by Braaksma, Aleida, Copenhaver, Martin S., Zenteno, Ana C., Ugarph, Elizabeth, Levi, Retsef, Daily, Bethany J., Orcutt, Benjamin, Turcotte, Kathryn M., Dunn, Peter F.

“…In this study, we used data from four surgical units in a large academic medical center to build a discrete-event simulation with which we show how a Just-In-Time (JIT) bed assignment, in which ready-to-move patients are assigned to ready-beds, would decrease bed idle time and increase access to general care beds for all surgical patients. Additionally, our simulation demonstrates the potential synergistic effects of combining the JIT assignment policy with a strategy that co-locates short-stay surgical patients out of inpatient beds, increasing the bed supply. …”
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