Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo by Hang, Liting, Wang, Ziyin, Foo, Aaron S. C., Goh, Geraldine, Choong, Huey Ching, Thundyil, John, Xu, Shengli, Lam, Kong-Peng, Lim, Kah-Leong

“…Taken together, these findings highlight the importance of neuronal energy homeostasis by AMPK in PD and position AMPK pathway as an attractive target for future therapeutic exploitation.…”
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Value-added products from thermochemical treatments of contaminated e-waste plastics by Das, Pallab, Gabriel, Jean-Christophe P., Tay, Chor Yong, Lee, Jong-Min

“…A basic framework of the existing processes has been established by reviewing the most interesting findings in recent times and the prospects that they open in the field recycling of e-waste plastics.…”
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Facial action unit detection using attention and relation learning by Shao, Zhiwen, Liu, Zhilei, Cai, Jianfei, Wu, Yunsheng, Ma, Lizhuang

“…Attention mechanism has recently attracted increasing attentions in the field of facial action unit (AU) detection. By finding the region of interest of each AU with the attention mechanism, AU-related local features can be captured. …”
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Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…Mitochondrial fusion and fission cycles are thus essential in the β-cell to maintain normal glucose, but not incretin, sensing. These findings broaden our understanding of the roles of mitofusins in β-cells, the potential contributions of altered mitochondrial dynamics to diabetes development, and the impact of incretins on this process.…”
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Metal mediated high performance antimicrobial hydrogel films for wound infection management: Zn, Cu, and Mg versus Ag and Au by Sen, Raj Kumar., Prabhakar, Priyanka, Mayandi, Venkatesh, Dwivedi, Neeraj, Yadav, Amit K., Solanki, Pratima R., Gupta, Ayush, Gowri, V. S., Lakshminarayanan, Rajamani, Verma, Navin Kumar, Mondal, D. P., Srivastava, Avanish Kumar, Dhand, Chetna

“…Strikingly, the Cu and Zn integrated hydrogels demonstrated broad-spectrum antimicrobial properties. The findings of this work thus reveal a more cost-effective, sustainable, and environmentally friendly approach to designing high-value-added wound care products.…”
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Optically detected magnetic resonance spectroscopic analyses on the role of magnetic ions in colloidal nanocrystals by Dehnel, Joanna, Harchol, Adi, Barak, Yahel, Meir, Itay, Horani, Faris, Shapiro, Arthur, Strassberg, Rotem, de Mello Donegá, Celso, Demir, Hilmi Volkan, Gamelin, Daniel R., Sharma, Kusha, Lifshitz, Efrat

“…The information extracted from the analyses of the ODMR spectra in those studies exposes fundamental physical parameters, such as g-factors, exchange coupling constants, and hyperfine interactions, together providing insights into the nature of the carrier (electron, hole, dopant), its local surroundings (isotropic/anisotropic), and spin dynamics. The findings illuminate the importance of ODMR spectroscopy in advancing our understanding of the role of magnetic ions in semiconductor nanocrystals and offer valuable knowledge for designing magnetic materials intended for various spin-related technologies.…”
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Lower serum uric acid and impairment of right cerebral hemisphere structural brain networks are related to depressive symptoms in cerebral small vessel disease: a cross-sectional s... by Yu, Lei, Yi, Ming, Guo, Jiayu, Li, Jinbiao, Zeng, Huixing, Cui, Liqian, Xu, Xiangming, Liu, Gang, Fan, Yuhua, Zeng, Jinsheng, Xing, Shihui, Chen, Yicong, Wang, Meng, Tan, Shuangquan, Jin, Leow Yi, Kumar, Dilip, Vipin, Ashwati, Ann, Soo See, Fatin Zahra Binte Zailan, Sandhu, Gurveen Kaur, Kandiah, Nagaendran, Dang, Chao

“…HAMD scores were significantly associated with nodal network metrics in the right cerebral hemisphere. Our findings suggested that lower SUA levels are significantly associated with disrupted structural brain networks in the right cerebral hemisphere of patients with SVD who have depressive symptoms.…”
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Effect mechanism of Er content variations on the mechanical and corrosion properties of T6 state Al–Mg–Si-xEr sheets by Cao, Puli, Zhu, Daibo, Wu, Na, Ouyang, Lingxue, Li, Chengbo, Liu, Yang, Zhu, Yulong, Liu, Jirong

“…This work investigates the influence of erbium (Er) content on the microstructure, mechanical properties, and corrosion behavior of T6 state AA6061 sheets. The findings reveal that nanoscale Al(Fe, Mn)Si particles are the main factors hindering dislocation motion and grain boundaries (GBs) migration. …”
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Environmental stress and emotional reactivity: an exploratory experience sampling method study by Wong, Corine Sau Man, Chan, Wai Chi, Lo, Kristen Wing Yan, Chen, Eric Yu Hai, Lam, Linda Chiu Wa

“…Conclusion: Using ESM, a valid, reliable, and easy-to-use self-reporting tool, our findings provided valuable insights on the potential mechanisms underlying emotional responses to stressful environments.…”
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Phonon stability boundary and deep elastic strain engineering of lattice thermal conductivity by Shi, Zhe, Tsymbalov, Evgenii, Shi, Wencong, Barr, Ariel, Li, Qingjie, Li, Jiangxu, Chen, Xing-Qiu, Dao, Ming, Suresh, Subra, Li, Ju

“…Computational work combining ab initio calculations and machine learning (ML) algorithms has further demonstrated that the bandgap of diamond can be altered significantly purely by reversible elastic straining. These findings open up unprecedented possibilities for designing materials and devices with extreme physical properties and performance characteristics for a variety of technological applications. …”
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Dynamic traffic safety risk assessment in road tunnel entrance zone based on drivers' psychophysiological perception states: methodology and case-study insights by Niu, Jia'an, Liang, Bo, Wong, Yiik Diew, He, Shiyong, Qin, Can, Wen, Sen

“…The results show that the traffic safety risk identification accuracy of the machine learning model proposed in this study reaches 95.13%, and the model can dynamically assess the real-time driving risk level. The findings have practical implications for the prevention of traffic crashes in the tunnel entrance zone and the realization of safe and stable operation of road tunnels.…”
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Motor adaptation with passive machines: A first study on the effect of real and virtual stiffness by Tommasino, Paolo, Melendez-Calderon, A., Burdet, E., Campolo, Domenico

“…In particular, we tested 20 healthy subjects under two different real stiffness conditions (Stiff Channel vs Compliant Channel) and two different virtual conditions (Viscous vs Springy). Our main finding is that compliance of the channel favours a better adaptation featured with less lateral errors and longer retention of the after-effect. …”
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Mechanisms of Yersinia YopO kinase substrate specificity by Lee, Wei Lin, Singaravelu, Pavithra, Wee, Sheena, Xue, Bo, Ang, Khay Chun, Gunaratne, Jayantha, Grimes, Jonathan M., Swaminathan, Kunchithapadam, Robinson, Robert C.

“…Using artificial substrates we clarified YopO’s substrate length requirements and its phosphorylation consensus sequence. These findings provide fresh insight into the mechanism of the YopO kinase and demonstrate that YopO executes a specific strategy targeting actin-modulating proteins, across multiple functionalities, to compete for control of their native phospho-signaling, thus hampering the cytoskeletal processes required for macrophage phagocytosis.…”
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Identification and characterization of roseltide, a knottin-type neutrophil elastase inhibitor derived from hibiscus sabdariffa by Nguyen, Giang Kien Truc, Tam, James Pingkwan, Loo, Shining, Kam, Antony, Xiao, Tianshu, Liu, Chuan Fa

“…Taken together, our findings demonstrate that roseltide rT1 is a novel knottin-type neutrophil elastase inhibitor with therapeutic potential for neutrophil elastase associated diseases.…”
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Modeling the change of beach profile under tsunami waves : a comparison of selected sediment transport models by Li, Linlin, Huang, Zhenhua

“…For real tsunamis, high suspended sediment concentration may occur, and density stratification and hindered settling effect play an important role; therefore, Delft3D, with both hindered settling and density stratification being considered, may perform better than XBeach. The findings reported here will be useful for researchers and practitioners working on tsunami hazard mitigation.…”
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A prospective observational study comparing rates of medical instability between adolescents with typical and atypical anorexia nervosa by Brennan, Cliona, Cini, Erica, Illingworth, Sarah, Chapman, Simon, Simic, Mima, Nicholls, Dasha, Chapman, Victoria, Simms, Conor, Hayes, Ellen, Fuller, Sarah, Orpwood, Jade, Tweedy, Nicola, Baksh, Tahmida, Astaire, Emma, Bhakta, Dee, Saglio, Eloise, Stevenson, Annie, Buchbinder, Melissa

“…A significant regression equation was found for percentage median body mass index, but not rate of weight loss, as a predictor of blood pressure, serum phosphorous and magnesium. Conclusions: Our findings indicate that medical instability occurs across a range of body weights in young people with AN and AAN. …”
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Computational Fluid Dynamics (CFD) Validation and Investigation the Effect of Piston Bowl Geometries Performance on Port Fuel InjectionHomogeneous Charge Compression Ignition (PFI-... by Nik Ab Rashid, Nik Muhammad Hafiz, Hairuddin, Abdul Aziz, Md Rezali, Khairil Anas, Masuri, Siti Ujila, Abdulabbas Mossa, Al Anbagi Muntasser, Jaafar, Jamiluddin, Fitriyana, Deni Fajar

“…The piston bowl design employed in a Port Fuel Injection engine application exhibited different combustion phases while demonstrating similarity in attaining in-cylinder pressure. The findings for swirl induce piston bowl design indicate an enhancement of in-cylinder pressure for the Spiral Crown geometry model, reaching 9.42 MPa. …”
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Green roof thermal performance of small-scale prototype using IES-VE simulation in tropical climatic condition by Md Yacob, Mohamad Norfekry, Kasmin, Hartini, Siti Nazahiyah Rahmat, Siti Nazahiyah Rahmat, Tukimat, Nurul Nadrah Aqilah, Ahmad Nazri, Mohd Ariff

“…Simulation using IES-VE approved that green roofs can potentially reduce indoor temperatures, demonstrating their suitability for tropical regions. These findings have significant implications for sustainable building design and urban planning in hot and humid climates.…”
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Physical unclonable function based solutions to unification of user, device and data authentication by Zheng, Yue

“…The non-repudiation assumption of these conventional techniques is being challenged by emerging artificial-intelligent assisted and malware-based attacks on independently chained weak links (factors), and their limited extension to IoT scenarios, where the sheer number of inexpensive and often insufficiently protected endpoints prevent application of standard, secret-key based techniques. …”
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Security for automotive electrical/electronic (E/E) architectures by Mundhenk, Philipp

“…The security approaches in this thesis are closely linked. Without a flexible message transmission scheme, authentication protocols cannot be implemented. …”
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