Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis by Ma, J

“…</p> <p>By monitoring the spontaneous tumour formation in mice, it was found that a lack of FIH expression does not profoundly affect the lifespan but accelerates the development of low-grade B cell lymphomas. …”

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress by Rodrigues, B, Leitão, RA, Santos, M, Trofimov, A, Silva, M, Inácio, ÂS, Abreu, M, Nobre, RJ, Costa, J, Cardoso, AL, Milosevic, I, Peça, J, Oliveiros, B, Pereira de Almeida, L, Pinheiro, PS, Carvalho, AL

“…Additionally, viral overexpression of miR-186-5p in the PFC of naïve mice induces anxiety- and depressive-like behaviours. …”

A cellular basis for mapping behavioural structure by El-Gaby, M, Harris, AL, Whittington, JCR, Dorrell, W, Bhomick, A, Walton, ME, Akam, T, Behrens, TEJ

“…The mice discovered the underlying task structure, enabling zero-shot inferences on the first trial of new tasks. …”

Functional integrity of visual coding following advanced photoreceptor degeneration by Rodgers, J, Hughes, S, Lindner, M, Allen, AE, Ebrahimi, AS, Storchi, R, Peirson, S, Lucas, RJ, Hankins, MW

“…Units from the WT and <em>ReaChR rd1</em> mice clustered together when subjected to unsupervised community detection based on stimulus-response properties. …”

Developing optogenetics for use in vascular research by Rorsman, N

“…</p> <p>2) Transgenic mice expressing ChR2(H134R) selectively in SMCs were generated. …”

Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

“…Causality between LRG1 and TNFR1 shedding was established by showing that Lrg1 -/- mice had lower plasma sTNFR1 concentrations than wild type mice. …”
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Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior by Ahumada-Marchant, Constanza, Ancatén-Gonzalez, Carlos, Haensgen, Henny, Brauer, Bastian, Merino-Veliz, Nicolas, Droste, Rita, Arancibia, Felipe, Horvitz, H. Robert, Constantine-Paton, Martha, Arriagada, Gloria, Chávez, Andrés E., Bustos, Fernando J.

“…In mice, mosaic KO of VPS50 in the hippocampus altered synaptic transmission and plasticity and generated robust cognitive impairments. …”
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Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria by Panda, Saswati, Zhang, Jing, Tan, Nguan Soon, Ho, Bow, Ding, Jeak Ling

“…AID−/− mice lacking IgG were susceptible to infection, unless reconstituted with natural IgG. …”
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Diffuse Correlation Spectroscopy (DCS) and Diffuse Optical Spectroscopy (DOS) for photodynamic therapy monitoring. by Siti Raudhah Matyasir.

“…Other parameters used are illumination time, light dose of PDT and fluence rate. Almost all mice went through photodynamic therapy at least twice. …”
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Functional genetics of cancer and congenital disorders by Zak, J

“…Examining new and published patients with 1q41q42 microdeletions, we found that <em>TP53BP2</em>, encoding ASPP2, is a strong candidate for being the gene responsible for brain morphological abnormalities of the syndrome. Mice deficient for <em>Trp53bp2</em> show multiple abnormalities overlapping the features of the 1q41q42 microdeletion syndrome such as dysmorphic lateral ventricles, heart and urogenital abnormalities. …”

Developing a personalized heterologous prime boost vaccination strategy for tumor therapy by Ramirez-Valdez, RA

“…In this study, a novel intravenous (IV) heterologous prime-boost vaccination strategy with a self-assembling neoantigen-peptide nanoparticle TLR-7/8 agonist (SNP) vaccine platform and a chimp adenovirus (ChAdOx1) was used to elicit high magnitude neoantigen-specific CD8 T cells and modulate the TME. Mice primed with SNP encoding the neoantigen Reps1 for a colon carcinoma (MC38) and boosted with ChAdOx1 IV encoding Reps1 elicited on average ~40% Reps1-specific CD8 T cell responses, which were ~4x higher than mice boosted by the conventional IM route. …”

Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation and molecular docking of mahogany seed extract (Swietenia mahagoni) as anti-hyperglycemic by Mushawwir Taiyeb, Mushawwir Taiyeb, Hartati Hartati, Hartati Hartati, Arwansyah Arwansyah, Arwansyah Arwansyah, Dahlia, Dahlia, Abd. Muis, Abd. Muis, A. Mu'nisa, A. Mu'nisa, Arif, Abdur Rahman, Md. Salleh, Liza

“…So, research was carried out to determine the formulation and optimization of nanoemulsion from mahogany seed extract (Swietenia mahagoni) and its effect on reducing blood glucose levels in mice (Mus musculus L.). Based on research that has been carried out, the nanoemulsion formula for mahogany seed extract is characterized by a transmittance percentage of 84.7 % and a particle size of 12.21 nm. …”
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Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

“…R. intestinalis administration significantly inhibited tumour formation in Apc(Min/+) mice, which was confirmed in mice with AOM-induced CRC. …”
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Finite element analysis on post-buckling of thin-walled structures using ANSYS by Theint, Yi Mon

“…The results obtained were checked against experimental data and led to the development and the revision of design procedures for the pin-ended lipped column and hollow box section.…”
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Driving mechanism development for autonomous hospital bed by Tan, Jia Liang

“…Demand is foreseen to spike and a range of healthcare services that range from acute to community care is necessary for a holistic healthcare system. …”
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Efficient position decoding methods based on fluorescence calcium imaging in the mouse hippocampus by Tu, Mengyu, Zhao, Ruohe, Adler, Avital, Gan, Wen-Biao, Chen, Zhe S.

“…Here, we develop an efficient strategy to extract features from fluorescence calcium imaging traces and further decode the animal's position. We validate our spike inference-free decoding methods in multiple in vivo calcium imaging recordings of the mouse hippocampus based on both supervised and unsupervised decoding analyses. …”
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Electrolyte-gated neuromorphic transistors for brain-like dynamic computing by He, Yongli, Jiang, Shanshan, Chen, Chunsheng, Wan, Changjin, Shi, Yi, Wan, Qing

“…Particularly, dynamics play an essential role in neural spike information processing. Here, we offer a brief review and perspective in the field of electrolyte-gated neuromorphic transistors for brain-like dynamic computing. …”
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Clustering of designers based on building information modeling event logs by Pan, Yue, Zhang, Limao, Skibniewski, Miroslaw J.

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Dual attention deep learning network for automatic steel surface defect segmentation by Pan, Yue, Zhang, Limao

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Policy complexity suppresses dopamine responses by Gershman, SJ, Lak, A

“…We show that male and female mice achieve performance on a perceptual decision task that is near-optimal given their capacity limits, as measured by policy complexity (the mutual information between states and actions). …”