Early-onset breast cancer in a woman with a germline mobile element insertion resulting in BRCA2 disruption : a case report by Deuitch, Natalie, Li, Shao-Tzu, Courtney, Eliza, Shaw, Tarryn, Dent, Rebecca, Tan, Veronique, Yackowski, Lauren, Torene, Rebecca, Berkofsky-Fessler, Windy, Ngeow, Joanne

“…Subsequent reanalysis for MEIs detected a novel likely pathogenic insertion of the retrotransposon element (RE) c.7894_7895insSVA in BRCA2. …”
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Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care by Olsen, JR, Piguet, V, Gallacher, J, Francis, NA

“…Children were found to be more likely to have an MC consultation if they had previously consulted a GP with AE (OR 1.13; 95% CI = 1.11 to 1.16; P<0.005).…”

Canadians' opinions towards COVID-19 data-sharing: a national cross-sectional survey by Savić Kallesøe, SA, Rabbani, T, Gill, EE, Brinkman, F, Griffiths, EJ, Zawati, M, Liu, H, Palmour, N, Joly, Y, Hsiao, WWL

“…Vaccination status was the most influential predictor of data-sharing opinion, with respondents who were ever vaccinated being 4.20 times more likely (95% CI 3.21 to 5.48, p=0.000) to be generally supportive of data-sharing than those unvaccinated. …”

The effect of pH on the production and composition of short- and medium-chain fatty acids from food waste in a leachate bed reactor at room temperature by Radadiya, Pooja, Latika, Ashika, Fei, Xunchang, Lee, Jangho, Mishra, Saurabh, Hussain, Abid

“…This study evaluated the hydrolysis and acidogenesis of food waste at different operating pHs (uncontrolled, 5.5, 6.5, 7.5, 8.5) in a leachate bed reactor (LBR) at room temperature. …”
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MAAD: A Model and Dataset for "Attended Awareness" in Driving by Gopinath, Deepak, Rosman, Guy, Stent, Simon, Terahata, Katsuya, Fletcher, Luke, Argall, Brenna, Leonard, John

“…In order to test our model, we capture a new dataset with a high-precision gaze tracker including 24.5 hours of gaze sequences from 23 subjects attending to videos of driving scenes. …”
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Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging by Xie, Chen, Zhen, Xu, Lei, Qunli, Ni, Ran, Pu, Kanyi

“…Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. …”
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Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…Cytotoxic effector clones were more likely to persist long-term following ICB and overlapped with public tumour-infiltrating lymphocyte clonotypes. …”

Insights from an Experiment Crowdsourcing Data from Thousands of US Amazon Users: The importance of transparency, money, and data use by Berke, Alex, Mahari, Robert, Pentland, Sandy, Larson, Kent, Calacci, Dana

“…This paper shares an innovative approach to crowdsourcing user data to collect otherwise inaccessible Amazon purchase histories, spanning 5 years, from more than 5,000 U.S. users. We developed a data collection tool that prioritizes participant consent and includes an experimental study design. …”
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Experimental and numerical studies of S960 ultra-high strength steel welded I-section columns by Su, Andi, Liang, Yating, Zhao, Ou

“…A testing programme, including initial geometric imperfection measurements and ten pin-ended column tests, was conducted. The testing programme was accompanied by a numerical modelling programme, where finite element models were firstly developed and validated against the test results, and then employed to perform parametric studies to generate further numerical data. …”
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A 15-year review of dengue hospitalizations in Singapore : reducing admissions without adverse consequences, 2003 to 2017 by Ang, Li Wei, Thein, Tun-Linn, Ng, Yixiang, Boudville, Irving Charles, Chia, Po Ying, Lee, Vernon Jian Ming, Leo, Yee-Sin

“…Further studies are needed to optimize dengue management in older adults who are more likely to be hospitalized with greater disease severity, given the higher proportions of hospitalizations and severe disease among older adults.…”
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16.31 Feedback Control Systems, Fall 2001 by How, Jonathan P.

“…By the end of the course, students should be able to design controllers using state-space methods and evaluate whether these controllers are "robust," that is, if they are likely to work well in practice.…”
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Synthesis and optical study of lead halide perovskites for opto-electronic applications by Ha, Son Tung

“…These methods usually result in polycrystalline film with many pin-holes and defects. As a physicist, my first aim is to find a way to prepare highest quality, single crystal samples for studying their intrinsic and fundamental properties. …”
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Molecular pathways leading to sleep and wakefulness in Drosophila by Christodoulou, K

“…Activation of the receptor likely feeds into a small GTPase cascade that involves Cv-c and Sandman.…”

The influence of metabolic hormones on lactation by Rostom, H

“…GH is therefore likely to augment the milk-synthesising actions of prolactin at lactation onset.…”

Defects in β-cell Ca2+ dynamics in age-induced diabetes by Li, Luosheng, Trifunovic, Aleksandra, Köhler, Martin, Wang, Yixin, Petrovic Berglund, Jelena, Illies, Christopher, Juntti-Berggren, Lisa, Larsson, Nils-Göran, Berggren, Per-Olof

“…We show that these changes are likely to be accounted for by impaired mitochondrial function and to involve phospholipase C/inositol 1,4,5-trisphosphate–mediated Ca2+ mobilization from intracellular stores as well as decreased β-cell Ca2+ influx over the plasma membrane. …”
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Versatile asymmetric separator with dendrite-free alloy anode enables high-performance Li-S batteries by Yan, Wenqi, Yang, Jin-Lin, Xiong, Xiaosong, Fu, Lijun, Chen, Yuhui, Wang, Zhaogen, Zhu, Yusong, Zhao, Jian-Wei, Wang, Tao, Wu, Yuping

“…Lithium-sulfur batteries (LSBs) with extremely-high theoretical energy density (2600 Wh kg-1 ) are deemed to be the most likely energy storage system to be commercialized. …”
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Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms by Sun, Yang, Chung, Hwa Hwa, Woo, Amanda Rui En, Lin, Valerie C.-L.

“…In conclusion, PRMT6 requires its methyltransferase activity to enhance ERα's ligand-induced activity, but its effect on ligand-independent activity is likely mediated through competing with Hsp90 for binding to the C-terminal domain of ERα. …”
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Ruthenium(ii) Polypyridyl complexes as FRET donors: structure- and sequence-selective DNA binding and anti-cancer properties by E. Elgar, Christopher, Yusoh, Nur Aininie, R. Tiley, Paul, Kolozsvári, Natália, G. Bennett, Laura, Gamble, Amelia, V. Péan, Emmanuel, L. Davies, Matthew, J. Staples, Christopher, Ahmad, Haslina, R. Gill, Martin

“…Based on this discovery, we developed a simple and rapid FRET binding assay to examine DNA-binding interactions of RPCs with diverse photophysical properties, including non-“light switch” complexes [Ru(dppz)2(5,5′dmb)]2+ and [Ru(PIP)2(5,5′dmb)]2+ (dppz = dipyridophenazine, 5,5′dmb = 5,5′-dimethyl-2,2′-bipyridine, PIP = 2-phenyl-imidazo[4,5-f][1,10]phenanthroline). …”

NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release by Wang, Qingyun, Wu, Shuquan, Zou, Juan, Liang, Xuyang, Mou, Chengli, Zheng, Pengcheng, Chi, Robin Yonggui

“…In addition to synthetic utilities, our control of reaction outcomes via in situ substrate modulation and release can likely inspire future reaction development.…”
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Long Covid: a global health issue – a prospective, cohort study set in four continents by Pazukhina, E, Garcia-Gallo, E, Reyes, LF, Kildal, AB, Jassat, W, Dryden, M, Holter, JC, Chatterjee, A, Gomez, K, Søraas, A, Puntoni, M, Latronico, N, Bozza, FA, Edelstein, M, Gonçalves, BP, Kartsonaki, C, Kruglova, O, Gaião, S, Chow, YP, Doshi, Y, Duque Vallejo, SI, Ibáñez-Prada, ED, Fuentes, YV, Hastie, C, O'Hara, ME, Balan, V, Menkir, T, Merson, L, Kelly, S, Citarella, BW, Semple, MG, Scott, JT, Munblit, D, Sigfrid, L

“…<p><strong> Results </p></strong>Of 11 860 participants (median age: 52 (IQR: 41–62) years; 52.1% females), 56.5% were from HICs and 43.5% were from LMICs. The proportion identified with Long Covid was significantly higher in HICs vs LMICs at both assessment time points (69.0% vs 45.3%, p<0.001; 69.7% vs 42.4%, p<0.001). …”