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Mice deficient in PAPP - a show resistance to the development of diabetic nephropathy
Published 2013“…Kidneys from diabetic WT mice showed multiple abnormalities including thickening of Bowman's capsule (100% of mice), increased glomerular size (80% of mice), tubule dilation (80% of mice), and mononuclear cell infiltration (90% of mice). …”
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Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not
Published 2020“…The C57BL/6J and C57BL/6N mice have well-documented phenotypic and genotypic differences, including the infamous nicotinamide nucleotide transhydrogenase (Nnt) null mutation in the C57BL/6J substrain, which has been linked to cardiovascular traits in mice and cardiomyopathy in humans. …”
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NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice
Published 2018“…Certain substrains of C57BL/6 mice contain a spontaneously occurring inactivatingmutation and display glucocorticoid deficiency along with glucose intolerance and reduced insulin secretion. …”
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The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice
Published 2022“…In this paper, we report a new generation of BET family inhibitor, NHWD870, that provide a complete and reversible contraceptive effect in mice which is stronger than that of JQ1 and its synthesized derivatives. …”
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Influence of rainfall pattern on suction distribution and slope stability
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Microbial induced calcite precipitation treatment on tropical residual soil
Published 2024Get full text
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