Uncovering the function of CREB regulated transcription coactivator 2 (CRTC2) in rodent brain by Lim, Wei Lee

“…CRTC2 translocation corresponds to a robust increase in p-CREB133 levels which likely triggers transcription of CREB target genes associated with glycogen metabolism. …”
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The mammalian EMC in membrane protein biogenesis by Volkmar, N

“…Sensitivity to cholesterol loss in EMC6 knockout cells was reproduced by direct deletion or pharmacological inhibition of SQS. mEMC depletion also caused imbalances in the mevalonate pathway, likely leading to increased shunting of the farnesyl pyrophosphate precursor into the isoprenoid pathway, increasing the detection of prenylated proteins. …”

'The burglar's mate'? How London's probation officers persuaded magistrates in Social Enquiry Reports, 1958-72 by Lunan, J

“…The university graduates therefore invoked normative character ideals in SERs because they believed it was likely to be the best way to achieve the desired outcome in court. …”

The responsible innovation of disruptive technologies by Inglesant, P, Webb, H, Ten Holter, C, Patel, M, Jirotka, M

“…Without effective intervention the response to these challenges is likely to be driven by economic interests. However, through RI, alternative futures are also possible. …”

Reconstructing prehistoric lifeways using multi-Isotope analyses of human enamel, dentine, and bone from Legaire Sur, Spain by Griffith, JI, James, HF, Ordoño, J, Fernández-Crespo, T, Gerritzen, CT, Cheung, C, Spros, R, Claeys, P, Goderis, S, Veselka, B, Snoeck, C

“…Oxygen and strontium isotope analysis suggest all individuals come from a similar, likely local, geological region, aside from one biological female who presents a notably different geographical birthplace, weaning, and dietary life history than the rest of the burial population. …”

Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Ferla, MP, Sánchez-García, R, Skyner, RE, Gahbauer, S, Taylor, JC, von Delft, F, Marsden, BD, Deane, CM

“…This method has had a prior real-world application in hit-to-lead screening, yielding a sub-micromolar merger from parent hits in a single round. It is therefore likely to further benefit future drug design campaigns and be integrated in future pipelines. …”

Highly variable freshwater reservoir offsets found along the Upper Lena watershed, Cis-Baikal, southeast Siberia by Schulting, R, Ramsey, CB, Bazaliiskii, VI, Weber, A

“…While the river flows over carbonate bedrock and is moderately alkaline, we suggest that old terrestrial carbon entering the riverine foodweb through bank erosion and other processes is a more likely candidate for the majority of the ¹⁴C offset.…”

Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience by Buccheri, S, James, S, Mafham, M, Landray, M, Melvin, T, Oldgren, J, Bulbulia, R, Bowman, L, Hoogervorst, LA, de Mheen, PJM, Juni, P, McCulloch, P, Fraser, AG

“…We summarize the essential principles and utility of large simple RCTs, likely applicable to all interventions but especially in order to promote their wider adoption to evaluate new medical devices.…”

Systematic assessment of COVID-19 host genetics using whole genome sequencing data by Schmidt, A, Casadei, N, Brand, F, Demidov, G, Vojgani, E, Abolhassani, A, Aldisi, R, Butler-Laporte, G, DeCOI host genetics group, Alawathurage, TM, Augustin, M, Bals, R, Bellinghausen, C, Berger, MM, Bitzer, M, Bode, C, Boos, J, Brenner, T, Cornely, OA, Eggermann, T, Erber, J, Feldt, T, Fuchsberger, C, Gagneur, J

“…We observed the presence of autosomal-recessive or likely compound heterozygous monogenic disorders in six individuals, all of which were hospitalized and significantly younger than the rest of the cohort. …”

Experimental heatwaves facilitate invasion and alter species interactions and composition in a tropical host‐parasitoid community by Chen, J, Lewis, O

“…The interactive effects of climate change and climate change-facilitated invasion have rarely been studied in multi-trophic communities, and are likely to differ depending on the nature of the climatic driver (i.e., climate extremes or constant warming). …”

Asymptomatic female softball pitchers have altered hip morphology and cartilage composition by Warden, SJ, Coburn, SL, Fuchs, RK, Surowiec, RK, Carballido-Gamio, J, Kemp, JL, Jalaie, PK, Hanff, DF, Palmer, AJR, Fernquest, SJ, Crossley, KM, Heerey, JJ

“…Pitch1 had 52% greater maximum alpha angle than Run (p < 0.001) and were 21.3 (95% CI 2.4 to 192.0) times more likely to have an alpha angle ≥ 60° within at least one hip. …”

Sleep and circadian difficulties in schizophrenia: presentations, understanding, and treatment by Freeman, D, Waite, F

“…Treatment is also very likely to lessen psychotic experiences and mood disturbances, while improving daytime functioning and quality of life. …”

Rediscovering Homo sapiens in international politics: evolution and rationality’s missing link by Johnson, D

“…An evolutionary perspective suggests: (1) rational choice is not always the most effective or efficient solution to decision-making problems; (2) cognitive biases are not mistakes, but adaptive “strategic instincts,” which evolved because they helped us make good decisions, not bad ones; (3) these “non-rational” dispositions follow a systematic pattern, allowing predictions about how people are likely to react under given conditions; (4) a theory for the origins of preferences; (5) an explanation for why humans can sometimes seem rational and sometimes non-rational (because adaptive behavior depends on context); and finally (6) error management theory suggests that cognitive biases evolved precisely because of uncertainty, as a way of minimizing costs over time. …”

Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Subsequently, the selected research projects that were carried out in the application of genetics and genetic technologies in cancer, especially breast cancer, infectious diseases and therapeutics, including genetic immunisation will be chronicled and highlighted. It is highly likely that human genetics research through the years will become an increasingly more integral component of medical research. …”
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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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Examining the relationship between organization justice and psychological contract, with perceived organizational support as mediator by Oh, Helena Hui Jun, Tan, Yee Sin, Tan, Yan Ling

“…In addition, we found some evidence that Perceived Organizational Support (POS) differentially mediated the relationships between the four dimensions of justice, and the perception of psychological contract fulfillment. We discuss our findings in terms of their implications for psychological contract research, and for the research on the multi-dimensionality of organizational justice.…”
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A correlational study between creative thinking ability and the performance of open-ended science investigations for secondary two female students by Md. Shahrin K.S. Moorthy.

“…The study was conducted with only secondary two female students as the researcher intended to use the findings in his current assignment in an all-girls Independent school.…”
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Doing business with and in Ireland : a case study of Accenture's challenges and strategies in Ireland by Ernie Widianty, Ng, Ying Thong, Puneet Narula, Tan, Sebastian Say Hwee

“…Contrary to our secondary research findings, our primary interviews in Ireland suggested that opportunities exist in times of crisis. …”
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Family dinner by Gan, Clara Li Juan

“…He is unable to control his children’s antics, and feels incompetent as a father and a husband. Finding a family recipe for fathers in a magazine, he prepares a dinner and cleans the house, hoping to create the illusion of the perfect family and to get reconnected with and impress his wife. …”
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Why is China in Africa? by Neo, Jackson Jie Sheng

“…This paper analyzes China's official financial flows to Africa by assessing 4 policies that could drive the financial flows. The paper finds that the Going Global Strategy is the primary determinant of official financial flows to Africa for the current phase of ChinaAfrica relations. …”
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