Website performance study by Qian, Lei

“…Taking into consideration customers’ high expectation of web application performance and potential negative consequences brought by poor performance, this report offers a comprehensive range of solutions to enhance web performance so as to perfect end-user experiences and further boost business bottom lines where applicable. The experiment was carried out on the self-built blog web application. …”
Get full text

Primary intestinal epithelial cell response to Helicobacter hepaticus in an ex vivo setting by Alrawaf, S

“…<p>Epithelial cells lining the intestinal mucosa play a critical role in mucosal immune homeostasis. …”

“Or they could just not use it?”: the dilemma of AI disclosure for audience trust in news by Toff, B, Simon, FM

“…We test whether audiences in the United States, where trust is particularly polarized along partisan lines, perceive news labeled as AI-generated as more or less trustworthy. …”

Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories by Dai, Y, Zhong, Y, Liu, H, Pan, R, Yuan, L, Du, J, Li, M, Wang, X, Shi, C, Liu, G, Zhu, P, Shimeld, S, Zhou, X, Li, G

“…We characterized cell specification at the mechanistic level and generated mutant lines to examine the function of five key transcription factors involved in neural specification. …”

Strategies to modulate Amorphous Oxide Semiconductor properties for low temperature transparent transistors by Kulkarni, Mohit Rameshchandra

“…Such surface modifications can achieve a change in the carrier concentration by change in work function or shifting- pinning of the Fermi level, or additional field generated due to dipoles created at the surface. …”
Get full text

Fabrication and characterization of graphene and carbon nanotube reinforced bioceramic nanocomposites by Hu, Huanlong

“…The reinforcing mechanism was due to the lubrication and pinning effects of rGO, which resulted in high resistance to penetration, elastic recovery capability, low-cycle fatigue resistance, and microcrack propagation inhibition properties. …”
Get full text

A deep learning-based fault detection and classification in smart electrical power transmission system by Khaleefah, Shihab Hamad, Mostafa, Salama A., Gunasekaran, Saraswathy Shamini, Khattak, Umar Farooq, Siti Salwani, Yaacob, Alanda, Alde

“…Electrical Power Transmission Networks (EPTN) are made of many complex, dynamic, and interrelated components. The transmission lines are essential components of the EPTN, and their fundamental duty is to transport electricity from the source area to the distribution network. …”
Get full text

Gum Arabic and breast cancer biology: Biotechnology perspective

“…The book also examines state-of-the-art breast cancer research, its impact on sustainable development goals, and the potential applications of AG's secondary metabolites in BC cell lines. Additionally, it discusses the opportunity to transfer cancer-on-a-chip technology to Islamic Development Bank member countries (IsDB-MCs) and explores the application of breast-on-a-chip technology using AGs-secondary metabolites (SME). …”
Get full text
Get full text

Avoidance of Concave Obstacles Through Rotation of Nonlinear Dynamics by Huber, Lukas, Slotine, Jean-Jacques, Billard, Aude

“…Controlling complex tasks in robotic systems, such as circular motion for cleaning or following curvy lines, can be dealt with using nonlinear vector fields. …”
Get full text

Chasing the city that cannot stop: Exploring transportation and urban co-development in São Paulo’s history by Borges Costa, Adriano, Zegras, P Christopher, Biderman, Ciro

“…Examining São Paulo’s “streetcar era” we find joint development of streetcar lines and urban expansion – evidence of joint development consistent with “streetcar suburbs.” …”
Get full text

Alternate Imaginaries for the Kinara: River Ravi’s Edge as a Threshold by Khalil, Mahwish

“…Finally, this thesis questions how the river's edge can be remapped to allow for the dismantling of top-down visions while addressing an urgency embodied within the shallow, receding flows of a polluted river, whose uncertain future remains contingent on distinct lines.…”
Get full text

Water-stable all-inorganic perovskite nanocrystals with nonlinear optical properties for targeted multiphoton bioimaging by Chan, Kok Ken, Giovanni, David, He, Huajun, Sum, Tze Chien, Yong, Ken-Tye

“…The toxicity of the CsPbBr3/SiO2/mPEG-DSPE nanocrystals has been evaluated in various cell lines. Subsequently, the encapsulated nanocrystals were used for targeted single and multiphoton imaging of cancer cells. …”
Get full text

Towards better urban intelligence: representation learning techniques for geospatial data analytics by Chen, Yile

“…They include points (e.g., points-of-interest), lines (e.g., road network), and polygons (e.g., geographical grids). …”
Get full text

Characterizing the interplay between super enhancers and chromatin interactions in cancer by Choudhary, Ruchi

“…Using HiChIP experiments in five human cell lines, we discovered multiple transcription factor (TF) clusters regulating chromatin interactions between SEs/enhancers and promoters, with one hub enriched in c-MYC and YY1. …”
Get full text

Investigating the human teashirt genes TSHZ2 and TSHZ3 in pancreatic and endocrine lineage commitment using genome modified human embryonic stem cells (hESC) by Eng, Shermaine Zi Hui

“…The CRISPR RNA-guided FokI-dCas9 nuclease (RFN) genome editing system was employed to create loss-of-function hESC lines. Two guide RNAs revealed successful editing in the 3’ end of TSHZ2 coding sequence while gRNAs tested for the 5’ end of TSHZ2 and for TSHZ3 were ineffective. …”
Get full text

Quantum dots-siRNA nanoplexes for gene silencing in central nervous system tumor cells by Lin, Guimiao, Chen, Ting, Zou, Jinyun, Wang, Yucheng, Wang, Xiaomei, Li, Jiefeng, Huang, Qijun, Fu, Zicai, Zhao, Yingying, Lin, Marie Chia-Mi, Xu, Gaixia, Yong, Ken-Tye

“…High gene transfection efficiency (>80%) was achieved on two glioblastoma cell lines, U87 and U251. The gene expression level (49.99 ± 10.23% for U87, 43.28 ± 9.66% for U251) and protein expression level (51.58 ± 7.88% for U87, 50.69 ± 7.59% for U251) of TERT is observed to decrease substantially after transfecting the tumor cells for 48 h. …”
Get full text
Get full text

Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506 by Kotaka, Masayo, Ye, Hong, Alag, Reema, Hu, Guangan, Bozdech, Zbynek, Preiser, Peter Rainer, Yoon, Ho Sup, Lescar, Julien

“…Compared to the human FKBP12−FK506 complex reported earlier, the structure reveals structural differences in the β5−β6 segment that lines the FK506 binding site. The presence in PfFKBD of Cys-106 and Ser-109 (substituting for His-87 and Ile-90, respectively, in human FKBP12), which are 4−5 Å from the nearest atom of the FK506 compound, suggests possible routes for the rational design of analogues of FK506 with specific antiparasitic activity. …”
Get full text
Get full text

Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation by Schneikert, Jean, Chandra, Shree Harsha Vijaya, Ruppert, Jan Gustav, Ray, Suparna, Wenzel, Eva Maria, Behrens, Jürgen

“…We show here that colon cancer cell lines express also the paralog APC-like (APCL or APC2). …”
Get full text
Get full text

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers by Erickson, A, Figiel, S, Rajakumar, T, Rao, S, Yin, W, Doultsinos, D, Magnussen, A, Singh, R, Poulose, N, Bryant, RJ, Cussenot, O, Hamdy, FC, Woodcock, D, Mills, IG, Lamb, AD

“…We first performed in-silico comparisons of inferred and directly resolved SNV and CNV status, from single cancer cells, from three different cell lines. We found that inferred SNV phylogenies accurately recapitulate DNA phylogenies (entanglement = 0.097). …”

Antifungal efficacy of kenaf seed peptides mixture in cheese, safety assessment and unravelling its action mechanism against food spoilage fungi by Arulrajah, Brisha, Qoms, Mohammed S., Muhialdin, Belal J., Zarei, Mohammad, Hussin, Anis Shobirin Meor, Hasan, Hanan, Chau, De-Ming, Ramasamy, Rajesh, Saari, Nazamid

“…The safety assessment showed that KSPM maintained the proliferation of normal cell lines up to 30 mg/mL. The cell surface potential energy and hydrophobicity of fungi were altered due to the potent interactions between the peptides and the cell envelope, with KSPM causing significant fungal cell wall permeability and subsequent disruption of the cytoplasmic membrane integrity. …”
Get full text