Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…Notably, Omicron’s high mutation count challenges antibody responses, yet T cell responses remain comparatively maintained, likely mitigating severe outcomes during Omicron waves.…”

A comparison of sodium-glucose co-transporter 2 inhibitor kidney outcome trial participants with a real-world chronic kidney disease primary care population by Forbes, AK, Hinton, W, Feher, MD, Elson, W, Ordóñez-Mena, JM, Joy, M, Fan, X, Banerjee, D, Cole, NI, Munro, N, Whyte, M, Suckling, RJ, Swift, PA, de Lusignan, S

“…Females were under-represented and less likely to be eligible for the trials.</p> <br> <p><strong>Conclusion:</strong> SGLT2 inhibitor kidney outcome trials represent a subgroup of people with CKD at high risk of adverse kidney events. …”

The influence of nicotinic acid adenine dinucleotide phosphate (NAADP) signalling and the significance of the organization of lysosomes in cardiac myocytes by Aston, D

“…</p> <p>Calcium released from the lysosome in response to NAADP action at TPC2 is thought to modulate calcium release from the SR. This process is likely to require a close spatial relationship between these organelles. …”

HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…<p>Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. …”

Environmental risk factors for self-harm during imprisonment: a prospective cohort study by Stephenson, T, Harris, I, Armstrong, C, Fazel, S, Short, R, Blackwood, N

“…Findings regarding staff-prisoner ratio and self-harm most likely reflect a reverse causal relationship. Replication in larger cohort studies is required to address the limitations of this pilot study.…”

The impact of social isolation on delayed hospital discharges of older hip fracture patients and associated costs by Landeiro, F, Leal, J, Gray, A

“…Patients who were admitted from an institution were less likely to have delayed discharges (OR 0.2) with 5.5 fewer days of delay. …”

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…Discordance between genetic and primary care data was also observed, e.g., abdominal aortic aneurysm and bladder cancer co-occurred in primary care but were not genetically correlated (Odds-Ratio = 2.23 [2.09:2.37], 𝑅𝑔 = 0.04 [−0.20:0.28]) and schizophrenia and fibromyalgia were less likely to co-occur together in primary care but were positively genetically correlated (OR = 0.84 [0.75:0.94], 𝑅𝑔 = 0.20 [0.11:0.29]).…”

Magnetic dynamics in iron-based superconductors probed by neutron spectroscopy by Taylor, A

“…This indicates that LiFeAs likely hosts an s± gap symmetry.</p> <p>I investigated two iron-phosphide systems, LaFePO and Sr2ScO3FeP, and in this case I was unable to identify any magnetic scattering. …”

Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Shamsi, ZA, Paraoan, V, Kim, C, Saifuddin, SR, Cosker, TDA, Whitwell, D, Gibbons, CLMH, Stavroulias, D, DiChiara, F

“…Variability in outcomes and overall survival likely stems from factors such as histological diversity, predominance of high-grade sarcomas, and wide age range at diagnosis. …”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Assessment of novel pre-erythrocytic malaria vaccines in humans by Venkatraman, N

“…In addition to humoral immunity, it is widely recognised that T-cell mechanisms are likely to play an important role in malaria immunity and heterologous prime-boost regimes using viral-vectored vaccines have been shown to induce potent T-cell responses. …”

A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border by Ansari, AT, Aung, KK, Win, HH, Beau, C, Nu, B, Soe, NL, Htoo, K, San, T, Wah, TG, Keereevijit, A, Phyo, AP, Chotivanich, K, White, NJ, Nosten, F, Hashmi, AH, Chu, CS

“…Patients of Karen ethnicity (OR 1.7, 95% CI 1.2–2.3; p = 0.001) or having a previous episode of malaria from any species (OR 1.6, 95% CI 1.1–2.3; p = 0.007) were more likely to report completing the 14-day primaquine radical cure regimen. …”

Multi-species rotational grazing of small ruminants regenerates undergrowth vegetation while controlling weeds in the oil palm silvopastoral system by Tohiran, Kamil Azmi, Nobilly, Frisco, Zulkifli, Raja, Yahya, Muhammad Syafiq, Norhisham, Ahmad Razi, Rasyidi, Md Zainal, Azhar, Badrul

“…The use of single-species livestock grazing is likely to cause oil palm growers to use herbicides to control undesirable weeds. …”
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The level of knowledge, attitude and practice towards Covid-19 immunisation among medical students in public medical schools in Malaysia by Mohamad Zainal, Nurul Hayati, Mohammed Ayyub, Safiyya, Yi, Chang Fang, Zaman, Arif Najmi Shahrir, Mohd Nor, Nurul Huda, Omar, Norsuhana, Ku Mohd Noor, Ku Mastura, Hamimi Wahid, Hanan

“…Respondents in the age group of 21 to 24 years old (p < 0.001) and 25 to 29 years old (p = 0.016), and Indian ethnicity (p = 0.006) were more likely to have good knowledge. Respondents registered in Malaysia’s National COVID-19 vaccination program were considered as having a positive attitude (n = 264, 61.8). …”
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Model of motivational forces influencing academic achievement among secondary school students through the mediation of flow by Syed Mustafa, Sharifah Muzila

“…It can be concluded that students with higher intrinsic and learning efficacy motivation were more likely to experience higher flow and thus perform better in their examination. …”
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Evolutionary explanations and the debunking of moral beliefs by Cofnas, N

“…I argue that our innate moral faculty is likely not the product of natural selection, but rather social selection. …”

Magnetoresistive sensor development roadmap (non-recording applications) by Zheng, Chao, Zhu, Ke, De Freitas, Susana Cardoso, Chang, Jen-Yuan, Davies, Joseph E., Eames, Peter, Freitas, Paulo P., Kazakova, Olga, Kim, Cheol Gi, Leung, Chi-Wah, Liou, Sy-Hwang, Ognev, Alexey, Piramanayagam, S. N., Ripka, Pavel, Samardak, Alexander, Shin, Kwang-Ho, Tong, Shi-Yuan, Tung, Mean-Jue, Wang, Shan X., Xue, Songsheng, Yin, Xiaolu, Pong, Philip W. T.

“…This paper provides a framework for MR sensor technology (non-recording applications) to be used for public and private R&D planning, in order to provide guidance into likely MR sensor applications, products, and services expected in the next 15 years and beyond.…”
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Vulnerability modeling, assessment, and improvement in urban metro systems: a probabilistic system dynamics approach by Chen, Hongyu, Chen, Bin, Zhang, Limao, Li, Hong Xian

“…The urban metro system is a complex system that is vulnerable to various kinds of hazards and subjected to dynamics, where errors in any part are very likely to cause system failures and accidents. A better understanding of evolutional dynamics of the system vulnerability over time enables to ensure the safety and security in its operation and provide guidance for long-term operation and maintenance for the metro system. …”
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Data-driven approach to spatiotemporal dynamic risk assessment of urban flooding based on shared socio-economic pathways by Wang, Mo, Chen, Furong, Zhang, Dongqing, Chen, Zijing, Su, Jin, Zhou, Shiqi, Li, Jianjun, Chen, Jintang, Li, Jiaying, Tan, Soon Keat

“…Under SSP126 scenario, nearly no change was predicted in the area with high flooding risk, with only increase of 1%, future urbanization hotspots associated with serious flooding risks will likely to be found on the fringe of the GBA's construction areas, in line with the extent of construction land expansion. …”
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Foot care behaviours and associated factors among patients with type 2 diabetes: a cross-sectional study by Ang, Chin-Siang, Goh, Kelley Fann Ing, Lodh, Nandika, Qin, Vicky Mengqi, Liew, Huiling, Sidhu, Harvinder Raj Singh, Ng, Jun Jie, Subramaniam, Tavintharan, Tan, Elaine, Koh, Gerald Choon Huat, Best, James, Wong, Julian, Car, Josip, Ho, Andy Hau Yan, Venkataraman, Kavita

“…The logistic regression analysis showed that current smokers were 60% less likely to practice good FC compared to non-smokers (odds ratio (OR) = 0.40; 95%; confidence interval (CI)= 0.22–0.73). …”
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