Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib by Miettinen, Teemu P., Peltier, Julien, Härtlova, Anetta, Gierliński, Marek, Jansen, Valerie M., Trost, Matthias, Björklund, Mikael

“…Loss of ECM29 activates the proteasome, blocks cell proliferation, and induces a senescence‐like phenotype. Finally, we find that ECM29 mRNA levels are predictive of relapse‐free survival in breast cancer patients treated with endocrine therapy. …”
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How J-chain ensures the assembly of immunoglobulin IgM pentamers by Giannone, Chiara, Mess, Xenia, He, Ruiming, Chelazzi, Maria R., Mayer, Annika, Bakunts, Anush, Nguyen, Tuan, Bushman, Yevheniia, Orsi, Andrea, Gansen, Benedikt, Degano, Massimo, Buchner, Johannes, Sitia, Roberto

“…Completion of an amyloid-like core triggers JC folding and drives disulfide rearrangements that covalently stabilize JC-containing pentamers. …”
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Flame retardancy of highly filled polyamide 6/clay nanocomposites by Dasari, Aravind, Yu, Zhong-Zhen, Mai, Yiu-Wing, Liu, Songlin

“…Factors such as incoherency, poor stability and non-uniformity of the char or the presence of large cracks and formation of island-like structures were insignificant in slowing down the heat release and mass loss rates. …”
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Entrapping of inclusions within carbon nanotubes during catalytic decomposition of C2H4 on a “thick” nickel film by Li, Feng Ji, Zhang, Sam, Sun, Geng Zhi, Kong, Jun Hua, Rawat, R. S., Ilyas, Usman, Li, Bo

“…The inner walls of a few tubes were sealed internally by multiple elongated “beads-like,” “bullet-shaped” or “needle-shaped” nickel inclusions. …”
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Bio-inspired categorization using event-driven feature extraction and spike-based learning by Zhao, Bo, Chen, Shoushun, Tang, Huajin

“…The proposed algorithm processes the address event data generated either from an image or from Address-Event-Representation (AER) temporal contrast vision sensor. Bio-inspired, cortex-like, spikebased features are obtained through event-driven convolution and neural competition. …”
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Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling by Rohatgi, Rajat, Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Covey, Douglas F, Siebold, Christian, Ingham, Philip William

“…The oxysterol-binding groove in the Smo CRD is analogous to that used by Frizzled 8 to bind to the palmitoleyl group of Wnt ligands and to similar pockets used by other Frizzled-like CRDs to bind hydrophobic ligands. The CRD is required for signaling in response to native Hh ligands, showing that it is an important regulatory module for Smo activation. …”
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Estimation of electric stress and surface potential for traction insulators by Reddy, B Subba, Madhulita, Monali, Chaudhuri, Tanaya

“…Constant exposure to detrimental effects of vandalism, and mechanical vibrations begets certain faults like shorting of sheds or cracks in the sheds. Due to fault in one/two sheds, stress on the remaining healthy sheds increases, owing to atmospheric pollution the stress may lead to a flashover of the insulator. …”
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Nature grasping by a cable-driven under-actuated anthropomorphic robotic hand by Tian, Li, Magnenat-Thalman, Nadia, Thalmann, Daniel, Zheng, Jianmin

“…How to grasp objects in different shapes like human hand. To deal with these three problems and further to provide a partial solution for duplicate human grasping, this paper introduces our method to solve these problems from robotic hand design, fabrication, actuation and grasping plan. …”
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Changi International Airport modelling and visualization by Kumar, Vaibhav

“…The models were designed to be modular to facilitate LEGO-like freedom in altering the taxiway design. Additionally, wireless cameras were mounted on top of the Air Traffic Control Tower model to simulate the Smart Tower capability that is currently installed on the actual ATC Tower of CIA. …”
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Insights into morphological evolution and cycling behaviour of lithium metal anode under mechanical pressure by Yin, Xuesong, Tang, Wei, Jung, Im Doo, Phua, Kia Chai, Adams, Stefan, Lee, Seok Woo, Zheng, Wesley Guangyuan

“…Instead of a highly porous, wire-like Li growth in the absence of pressure, a much more compact Li deposition can be achieved when a pressure is applied to the batteries in the charge/discharge processes. …”
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Deep learning assisted optical wavefront shaping in disordered medium by Luo, Yunqi, Li, Huanhao, Zhang, Ruochong, Lai, Puxiang, Zheng, Yuanjin

“…Wavefront shaping (WFS) has been put forward several years ago to break the limitation caused by optical scattering in inhomogeneous medium, and realize optical focusing in disordered medium like biological tissues. However, usually, with traditional methods, WFS is time consuming and not cost efficient since it requires long time to obtain the information of the scattering medium. …”
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Investigation on chemical protease, nuclease and catecholase activity of two copper complexes with flexidentate Schiff base ligands by Das, Mriganka, Kundu, Bidyut Kumar, Tiwari, Ritudhwaj, Mandal, Poulami, Nayak, Debasis, Ganguly, Rakesh, Mukhopadhyay, Suman

“…Furthermore enzyme kinetic studies were also performed for those two complexes towards effectiveness in mimicking catecholase like activities. Overall all the experimental results reveal the potential activity of these copper complexes towards protease, nuclease and catecholase activity. …”
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Stress singularity of a notch in a higher-order elastic solid under anti-plane deformation by Wu, Mao See

“…Specifically, for a given notch angle the stress exponent becomes more negative with decrease in the first Lamé constant λ and the third-order elastic constant n, and with the increase in the magnitude of the negative third-order constant m, while it varies non-monotonically with the second Lamé constant (shear modulus) µ.These results have significant implications for notch-like defects in soft solids, e.g., replacement tissues, industrial robots and devices in biomedical applications.…”
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Development of organically modified montmorillonite/polypropylene composite powders for selective laser sintering by Tan, Lisa Jiaying, Zhu, Wei, Zhou, Kun

“…It was found that at low loadings, nanofillers with sheet-like structures such as OMMT could limit the increase in crystallization temperatures of the composite powder, thus ensuring their wide sintering windows for SLS.…”
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Influence of admixture on 3D printable construction material by Tay, Daniel Yi Wei, Tan, Ming Jen

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Another decade of photoacoustic imaging by Das, Dhiman, Sharma, Arunima, Rajendran, Praveenbalaji, Pramanik, Manojit

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On use of deep learning for side channel evaluation of black box hardware AES engine by Won, Yoo-Seung, Bhasin, Shivam

“…Thus, proper evaluation against vulnerabilities like side-channel attacks is a challenge in absence of architecture information and thus leakage model. …”
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Evolutionary multitasking : a computer science view of cognitive multitasking by Ong, Yew-Soon, Gupta, Abhishek

“…To this end, the present paper is dedicated to a detailed exposition on a so-far underexplored characteristic of population-based search algorithms, i.e., their inherent ability (much like the human mind) to handle multiple optimization tasks at once. …”
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Enlightenment in The Age of Phillis — The Age of Phillis (Roundtable) by DeLucia, JoEllen

“…What does the eight-eenth century look like when we center the experience of Phillis Wheatley Peters instead of Enlightenment philosophy, neoclassical poetics, or Samuel Johnson? …”
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Object tracking enhanced interactive pinball display by Tan, Bryan Zhen Ye

“…An old-school pinball board with the necessary components like flippers, obstacles and a controller is reborn.…”
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