Effective antibodies immobilization and functionalized nanoparticles in a quartz-crystal microbalance-based immunosensor for the detection of parathion by Della Ventura, Bartolomeo, Iannaccone, Marco, Funari, Riccardo, Pica Ciamarra, Massimo, Altucci, Carlo, Capparelli, Rosanna, Roperto, Sante, Velotta, Raffaele

“…A pesticide like parathion (M = 292 Da) is a typical example of contaminant for which a signal amplification procedure is desirable. Methods/Findings: The ballasting of the analyte by gold nanoparticles has been already applied to heavy target as proteins or bacteria to improve the limit of detection. …”
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Interface energetics and dynamics in organic-inorganic hybrid perovskites by Goh, Teck Wee

“…Firstly, the interface energetics of FAPbI3-based perovskites with organic charge extraction layers showed apparent upward band bending, but its origin is unexpectedly due to presence of δ-FAPbI3. This finding implicates solar cell operation as it causes inefficient extraction of photoexcited electrons to the PCBM. …”
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Putting salient vocalizations in context : adults' physiological arousal to emotive cues in domestic and external environments by Azhari, Atiqah, Truzzi, Anna, Rigo, Paola, Bornstein, Marc H., Esposito, Gianluca

“…The implicit task also elicited lower LFHF index in response to both IL and IC than control sound (CS), only amongst females. Findings highlight the important roles that contextual information and cognitive demand play in regulating physiological responses to salient emotive vocalizations. …”
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Mechanical performance of carbon fibre reinforced vinyl ester composite plate bonded concrete exposed to tropical climate by Abu Hassan, Shukur

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Reservoir system modelling using nondominated sorting genetic algorithm in the framework of climate change by Tukimat, Nurul Nadrah Aqilah

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Mixed tree nuts, cognition and gut microbiota: a 4-week, placebo-controlled, randomized crossover trial in healthy non-elderly adults by Haskell-Ramsay, Crystal, Dodd, Fiona L., Smith, Darren, Cuthbertson, Lewis, Nelson, Andrew, Lodge, John K., Jackson, Philippa A.

“…Conclusions: These findings indicate a positive effect of nut on cognition following only 4-weeks' consumption in a healthy non-elderly sample, as well as upregulation of a microbial taxa associated with gut health. …”
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Marta Czok URBE by Scarso, Jacek Ludwig, Ionescu, Georgiana, Czok, Marta

“…In Marta Czok's paintings, the city can be defined as a metaphorical fulcrum, through which society is portrayed in complex, often crowded depictions, where the individual finds their meaning within the social relations in which they are immersed. …”
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Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…</p> <p>Together, these findings underscore the importance of T cell immunity in sustaining protection against SARS-CoV-2 variants. …”

Halving premature death and improving quality of life at all ages by Norheim, OF, Chang, A, Bolongaita, S, Barraza-Lloréns, M, Jha, P, Lewington, S, Jamison, DT, Peto, R

“…</p> <br> <p><strong>Findings:</strong> Globally, PPD decreased from 56% in 1970 to 31% in 2019, although some countries saw reversals because of conflict, social instability, or HIV and AIDS. …”

Prognostic significance of pleural fluid microbiological positivity in pleural infection: a bicentric 10-year retrospective observational study by Wong, C, Fan, HC, Rahman, NM, Wong, JCC, Cheng, HS, Chiu, PH, Tong, CW, Miu, FPL, Yam, LYC

“…Conclusions: Pleural fluid microbiological positivity is independently associated with increased mortality in patients with pleural infections. This finding should complement the RAPID score in risk stratification and inform future research aimed at improving outcomes in this patient population.…”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…</p> <br> <p><strong>Discussion:</strong> These findings indicate an epitope-specific pathophysiology of LGI1 autoantibodies. …”

Characterisation of collagen type I/ type II composite scaffolds for osteochondral tissue engineering by Tamaddon, M

“…The addition of chondroitin sulphate and fibrillogenesis increased the rigidity of the collagen chains and the viscosity of suspensions, thereby affecting the pore structure of the final scaffolds. A very important finding was that stem cells produced mostly collagen type II matrix molecules on these scaffolds, which differed from the production of collagen type I on type I scaffolds.…”

Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis by Donkor, ES, Osman, A, Aglomasa, BC, Awere-Duodu, A, Odoom, A, Opoku-Asare, B, Lazarus, G

“…Conclusion: This review identified gaps in knowledge and highlighted areas where prompt actions are required, it further guides future research endeavors and policy development. The findings underscore the need for further implementation of AMS programs across the West African region to enhance understanding of antibiotic use patterns, prescribing practices, and the factors influencing them in the region.…”

Translated and culturally adapted internet-delivered cognitive therapy for social anxiety disorder in Japanese clinical settings: study protocol for a randomised controlled trial by Yoshinaga, N, Thew, G, Hayashi, Y, Tanoue, H, Nakai, M, Clark, DM

“…An internet-delivered version of this treatment protocol (iCT-SAD) has recently been developed in the UK as a way to overcome this challenge, demonstrating comparable outcomes to face-to-face CT-SAD whilst requiring less therapist time per client. Initial findings also suggest its cross-cultural transferability, but the previous studies in other cultural settings used the English language programme and only included English-fluent participants as a second language. …”

Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…I carried out validation and mechanistic studies that confirmed that loss of TMED2 and TMED10 results in nuclear FoxO1-Clover retention following insulin treatment, as well as aberrant AKT phosphorylation. These findings confirmed that TMED2 and TMED10 are novel regulators of hepatic insulin signalling.…”

The molecular determinants of Polycomb-mediated gene repression by Fursova, N

“…In conclusion, through systematic dissection of the Polycomb system, I have provided compelling evidence for a variant PRC1-dependent logic for formation of Polycomb chromatin domains and repression of Polycomb target genes. Together, my findings place PRC1 and its catalytic activity at the forefront of Polycomb-mediated transcriptional silencing, paving the way for a mechanistic understanding of Polycomb system function.…”

Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…</p> <p>My studies and thesis underscore the potential of NTX as a viable alternative for bacterial infection prevention/treatment in poultry farming. The findings contribute to the development and prudent use of NTX in farm animal production, offering a promising solution to the challenge of AMR in agriculture.…”

Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Amboko, B, Nzinga, J, Tsofa, B, Mugo, P, Musiega, A, Maritim, B, Wong, E, Mazzilli, C, Ng’ang’a, W, Hagedorn, B, Turner, G, Musuva, A, Murira, F, Ravishankar, N, Hussein, S, Barasa, E

“…The two strands will be mixed during data collection to refine questions, with findings triangulated during analysis and interpretation to provide a comprehensive understanding of PCN implementation. …”

Childlessness and its associated factors among Chinese women: a nationwide population-based study by Han, Q, Dang, J, Wu, Y, Ye, W

“…Conclusions: This study used the most recent nationwide survey data from China to identify factors associated with childlessness and reproductive anxiety, with an emphasis on socio-economic factors and domestic violence. The findings highlight the significant impact of domestic violence on fertility behaviors and reproductive anxiety, providing valuable evidence for future policy interventions.…”

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…We classified pairs of conditions as across or within-domain based on the international classification of disease.</p> <p><strong>Findings: </strong>We identified 72 chronic conditions, with 43.6% of 2546 pairs showing higher co-occurrence than chance in primary care and evidence of shared genetics. …”