Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria by Panda, Saswati, Zhang, Jing, Tan, Nguan Soon, Ho, Bow, Ding, Jeak Ling

“…AID−/− mice lacking IgG were susceptible to infection, unless reconstituted with natural IgG. …”
Get full text
Get full text

Diffuse Correlation Spectroscopy (DCS) and Diffuse Optical Spectroscopy (DOS) for photodynamic therapy monitoring. by Siti Raudhah Matyasir.

“…Other parameters used are illumination time, light dose of PDT and fluence rate. Almost all mice went through photodynamic therapy at least twice. …”
Get full text

Functional genetics of cancer and congenital disorders by Zak, J

“…Examining new and published patients with 1q41q42 microdeletions, we found that <em>TP53BP2</em>, encoding ASPP2, is a strong candidate for being the gene responsible for brain morphological abnormalities of the syndrome. Mice deficient for <em>Trp53bp2</em> show multiple abnormalities overlapping the features of the 1q41q42 microdeletion syndrome such as dysmorphic lateral ventricles, heart and urogenital abnormalities. …”

Developing a personalized heterologous prime boost vaccination strategy for tumor therapy by Ramirez-Valdez, RA

“…In this study, a novel intravenous (IV) heterologous prime-boost vaccination strategy with a self-assembling neoantigen-peptide nanoparticle TLR-7/8 agonist (SNP) vaccine platform and a chimp adenovirus (ChAdOx1) was used to elicit high magnitude neoantigen-specific CD8 T cells and modulate the TME. Mice primed with SNP encoding the neoantigen Reps1 for a colon carcinoma (MC38) and boosted with ChAdOx1 IV encoding Reps1 elicited on average ~40% Reps1-specific CD8 T cell responses, which were ~4x higher than mice boosted by the conventional IM route. …”

Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation and molecular docking of mahogany seed extract (Swietenia mahagoni) as anti-hyperglycemic by Mushawwir Taiyeb, Mushawwir Taiyeb, Hartati Hartati, Hartati Hartati, Arwansyah Arwansyah, Arwansyah Arwansyah, Dahlia, Dahlia, Abd. Muis, Abd. Muis, A. Mu'nisa, A. Mu'nisa, Arif, Abdur Rahman, Md. Salleh, Liza

“…So, research was carried out to determine the formulation and optimization of nanoemulsion from mahogany seed extract (Swietenia mahagoni) and its effect on reducing blood glucose levels in mice (Mus musculus L.). Based on research that has been carried out, the nanoemulsion formula for mahogany seed extract is characterized by a transmittance percentage of 84.7 % and a particle size of 12.21 nm. …”
Get full text

Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

“…R. intestinalis administration significantly inhibited tumour formation in Apc(Min/+) mice, which was confirmed in mice with AOM-induced CRC. …”
Get full text

Living with fibrodysplasia ossificans progressiva: radiological images of a patient with extensive heterotopic ossification by Mohammed Mostafa Kotb, Omar, Usama Farghaly, Kaliya-Perumal, Arun-Kumar

“…Radiographic evaluation with X-rays and CT scans revealed scoliosis and total fusion of almost all levels of the spine, with only a few disc spaces spared. A large mass of heterotopic bone was observed, corresponding to the location of the paraspinal muscles in the lumbar region, branching upwards and fusing with the scapulae on both sides. …”
Get full text
Get full text

Finite element analysis on post-buckling of thin-walled structures using ANSYS by Theint, Yi Mon

“…The results obtained were checked against experimental data and led to the development and the revision of design procedures for the pin-ended lipped column and hollow box section.…”
Get full text

Driving mechanism development for autonomous hospital bed by Tan, Jia Liang

“…Demand is foreseen to spike and a range of healthcare services that range from acute to community care is necessary for a holistic healthcare system. …”
Get full text

Efficient position decoding methods based on fluorescence calcium imaging in the mouse hippocampus by Tu, Mengyu, Zhao, Ruohe, Adler, Avital, Gan, Wen-Biao, Chen, Zhe S.

“…Here, we develop an efficient strategy to extract features from fluorescence calcium imaging traces and further decode the animal's position. We validate our spike inference-free decoding methods in multiple in vivo calcium imaging recordings of the mouse hippocampus based on both supervised and unsupervised decoding analyses. …”
Get full text

Electrolyte-gated neuromorphic transistors for brain-like dynamic computing by He, Yongli, Jiang, Shanshan, Chen, Chunsheng, Wan, Changjin, Shi, Yi, Wan, Qing

“…Particularly, dynamics play an essential role in neural spike information processing. Here, we offer a brief review and perspective in the field of electrolyte-gated neuromorphic transistors for brain-like dynamic computing. …”
Get full text

Clustering of designers based on building information modeling event logs by Pan, Yue, Zhang, Limao, Skibniewski, Miroslaw J.

Get full text

Dual attention deep learning network for automatic steel surface defect segmentation by Pan, Yue, Zhang, Limao

Get full text

The inference-boundary model reinterpreting theme and rheme by Leong, Ping Alvin

“…The Hallidayan notions of theme and rheme pose an interesting challenge to linguists in their attempts to pin them down more specifically. This paper argues that since the thematic structure of the clause organises it as a message, a useful starting point in theme–rheme research is an understanding of how clausal messages are typically processed by language users. …”
Get full text
Get full text

Policy complexity suppresses dopamine responses by Gershman, SJ, Lak, A

“…We show that male and female mice achieve performance on a perceptual decision task that is near-optimal given their capacity limits, as measured by policy complexity (the mutual information between states and actions). …”

Design and Implementation of Active Antennas for IoT-Based Healthcare Monitoring System by MUSA, UMAR, MOHD SHAH, SHAHARIL, A. MAJID, HUDA, AHMAD MAHADI, ISMAIL, A. RAHIM, MOHAMAD KAMAL, YAHYA, MUHAMMAD SANI, ZAINAL ABIDIN, ZUHAIRIAH

“…Two dual-band (2.4 GHz and 5.8 GHz) microstrip patch antennas, one with a PIN diode and one without, are fabricated using Rogers Duroid RO3003™ substrate. …”
Get full text

Design and Implementation of Active Antennas for IoT-Based Healthcare Monitoring System by MUSA, UMAR, MOHD SHAH, SHAHARIL, A. MAJID, HUDA, MAHADI, ISMAIL AHMAD, A. RAHIM, MOHAMAD KAMAL, YAHYA, MUHAMMAD SANI, ZAINAL ABIDIN, ZUHAIRIAH

“…Two dual-band (2.4 GHz and 5.8 GHz) microstrip patch antennas, one with a PIN diode and one without, are fabricated using Rogers Duroid RO3003™ substrate. …”
Get full text

Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in K... by Lugano, D, Kutima, B, Kimani, M, Sigilai, A, Gitonga, J, Karani, A, Akech, D, Karia, B, Ziraba, AK, Maina, A, Lambisia, A, Omuoyo, D, Mugo, D, Lucinde, R, Owuor, S, Konyino, G, Newman, J, Bailey, D, Nduati, E, Githinji, G, Agoti, CN, Bejon, P, Scott, JAG, Agweyu, A, Warimwe, GM

“…The majority of these mutations mainly target the spike protein, allowing the new variants to escape the immunity previously raised by vaccination and/or infection by earlier variants of SARS-CoV-2. …”

An immunoinformatic approach for identifying and designing conserved multi-epitope vaccines for coronaviruses by Ong, Yu Chuan, Tejo, Bimo Ario, Yap, Wei Boon

“…Methods: This study utilized an immunoinformatic approach to identify evolutionarily conserved CD4+ (HTL) and CD8+ (CTL) T cells, and B-cell epitopes in the coronaviral spike (S) glycoprotein. Results: A total of 132 epitopes were identified, with the majority of them found to be conserved across the bat CoVs, pangolin CoVs, endemic coronaviruses, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV). …”
Get full text

Banks regulatory reforms in Singapore. by Foo, Cindy Ping Ping., Lee, Shirleen Sok Loon., Ng, Mui Chee.

Get full text