Reservoir system modelling using nondominated sorting genetic algorithm in the framework of climate change by Tukimat, Nurul Nadrah Aqilah

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Mixed tree nuts, cognition and gut microbiota: a 4-week, placebo-controlled, randomized crossover trial in healthy non-elderly adults by Haskell-Ramsay, Crystal, Dodd, Fiona L., Smith, Darren, Cuthbertson, Lewis, Nelson, Andrew, Lodge, John K., Jackson, Philippa A.

“…Conclusions: These findings indicate a positive effect of nut on cognition following only 4-weeks' consumption in a healthy non-elderly sample, as well as upregulation of a microbial taxa associated with gut health. …”
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An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…Results: Using quantitative analysis, we found significantly lower levels of DNA methylation in the UGT1A1 locus in the anosmia group compared to the normosmia group, with a 14% decrease in median methylation values in patients with smell loss (p < 0.0001). These findings highlight potential epigenomic alterations in the UGT1A1 gene that may contribute to the pathogenesis of anosmia following COVID-19 infection. …”
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Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…</p> <p>Together, these findings underscore the importance of T cell immunity in sustaining protection against SARS-CoV-2 variants. …”

Halving premature death and improving quality of life at all ages by Norheim, OF, Chang, A, Bolongaita, S, Barraza-Lloréns, M, Jha, P, Lewington, S, Jamison, DT, Peto, R

“…</p> <br> <p><strong>Findings:</strong> Globally, PPD decreased from 56% in 1970 to 31% in 2019, although some countries saw reversals because of conflict, social instability, or HIV and AIDS. …”

Prognostic significance of pleural fluid microbiological positivity in pleural infection: a bicentric 10-year retrospective observational study by Wong, C, Fan, HC, Rahman, NM, Wong, JCC, Cheng, HS, Chiu, PH, Tong, CW, Miu, FPL, Yam, LYC

“…Conclusions: Pleural fluid microbiological positivity is independently associated with increased mortality in patients with pleural infections. This finding should complement the RAPID score in risk stratification and inform future research aimed at improving outcomes in this patient population.…”

Signature methods in machine learning by Lyons, T, McLeod, A

“…<br> Hopefully, by working some of the examples the reader will find access to useful and simple to deploy tools; tools that are moderately effective in analysing longitudinal data that is complex and irregular in contexts where massive machine learning is not a possibility. …”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…</p> <br> <p><strong>Discussion:</strong> These findings indicate an epitope-specific pathophysiology of LGI1 autoantibodies. …”

Human agency and instrumental rationality: applying human capital to gender inequalities and intergenerational stratification by Luo, H

“…</p></br> <p><strong>Main Findings</strong></p> <p>Human Capital Transfer Between Spouses: Within marital relationships, a transfer of human capital exists. …”

Guaranteed bounds on posterior distributions of discrete probabilistic programs with loops by Zaiser, F, Murawski, AS, Ong, C-HL

“…By contrast, we aim to find guaranteed bounds, which sandwich the true distribution. …”

Characterisation of collagen type I/ type II composite scaffolds for osteochondral tissue engineering by Tamaddon, M

“…The addition of chondroitin sulphate and fibrillogenesis increased the rigidity of the collagen chains and the viscosity of suspensions, thereby affecting the pore structure of the final scaffolds. A very important finding was that stem cells produced mostly collagen type II matrix molecules on these scaffolds, which differed from the production of collagen type I on type I scaffolds.…”

Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis by Donkor, ES, Osman, A, Aglomasa, BC, Awere-Duodu, A, Odoom, A, Opoku-Asare, B, Lazarus, G

“…Conclusion: This review identified gaps in knowledge and highlighted areas where prompt actions are required, it further guides future research endeavors and policy development. The findings underscore the need for further implementation of AMS programs across the West African region to enhance understanding of antibiotic use patterns, prescribing practices, and the factors influencing them in the region.…”

Translated and culturally adapted internet-delivered cognitive therapy for social anxiety disorder in Japanese clinical settings: study protocol for a randomised controlled trial by Yoshinaga, N, Thew, G, Hayashi, Y, Tanoue, H, Nakai, M, Clark, DM

“…An internet-delivered version of this treatment protocol (iCT-SAD) has recently been developed in the UK as a way to overcome this challenge, demonstrating comparable outcomes to face-to-face CT-SAD whilst requiring less therapist time per client. Initial findings also suggest its cross-cultural transferability, but the previous studies in other cultural settings used the English language programme and only included English-fluent participants as a second language. …”

Data for the ‘Orchid Observers’ project by Shuttleworth, S, O’Donnell, J, Lintott, C, Tweddle, J

“…The Natural History Museum (NHM) wants to find out if this is true for other wild orchids and whether all species are responding in the same way. …”

Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…I carried out validation and mechanistic studies that confirmed that loss of TMED2 and TMED10 results in nuclear FoxO1-Clover retention following insulin treatment, as well as aberrant AKT phosphorylation. These findings confirmed that TMED2 and TMED10 are novel regulators of hepatic insulin signalling.…”

ALMA spectral survey of Supernova 1987A – molecular inventory, chemistry, dynamics and explosive nucleosynthesis by Matsuura, M, Indebetouw, R, Woosley, S, Bujarrabal, V, Abellán, F, McCray, R, Kamenetzky, J, Fransson, C, Barlow, M, Gomez, H, Cigan, P, De Looze, I, Spyromilio, J, Stavely-Smith, L, Zanardo, G, Roche, P, Larsson, J, Viti, S, Van Loon, J, Wheeler, J, Baes, M, Chevalier, R, Lundqvist, P, Marcaide, J, Dwek, E, Meixner, M, Ng, C, Sonneborn, G, Yates, J

“…This is the first identification of HCO⁺ and SO in a young supernova remnant. We find a dip in the J = 6–5 and 5–4 SiO line profiles, suggesting that the ejecta morphology is likely elongated. …”

The molecular determinants of Polycomb-mediated gene repression by Fursova, N

“…In conclusion, through systematic dissection of the Polycomb system, I have provided compelling evidence for a variant PRC1-dependent logic for formation of Polycomb chromatin domains and repression of Polycomb target genes. Together, my findings place PRC1 and its catalytic activity at the forefront of Polycomb-mediated transcriptional silencing, paving the way for a mechanistic understanding of Polycomb system function.…”

Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…</p> <p>My studies and thesis underscore the potential of NTX as a viable alternative for bacterial infection prevention/treatment in poultry farming. The findings contribute to the development and prudent use of NTX in farm animal production, offering a promising solution to the challenge of AMR in agriculture.…”

Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Amboko, B, Nzinga, J, Tsofa, B, Mugo, P, Musiega, A, Maritim, B, Wong, E, Mazzilli, C, Ng’ang’a, W, Hagedorn, B, Turner, G, Musuva, A, Murira, F, Ravishankar, N, Hussein, S, Barasa, E

“…The two strands will be mixed during data collection to refine questions, with findings triangulated during analysis and interpretation to provide a comprehensive understanding of PCN implementation. …”

Investigating the functional and metabolic role of carnitine in the diabetic heart using hyperpolarized MRI by Savic, D

“…</p> <p>Different diabetic models were initially investigated to find the most appropriate model in which to modulate L-carnitine levels. …”