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  1. 281
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    Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes by Šimelis, K, Belle, R, Kawamura, A

    Published 2024
    “…Simultaneous detection of substrate and cofactors is difficult, contributing to a poor understanding of the dynamics between substrate oxidation and 2OG decarboxylation activities. Here, we profile 5-methylcytosine (5mC)-oxidising Ten-Eleven Translocation (TET) enzymes using MS and 1H NMR spectroscopy methods and reveal a high degree of substrate oxidation-independent 2OG turnover under a range of conditions. 2OG decarboxylase activity is substantial (>20% 2OG turned over after 1 h) in the absence of substrate, while, under substrate-saturating conditions, half of total 2OG consumption is uncoupled from substrate oxidation. 2OG kinetics are affected by substrate and non-substrate DNA oligomers, and the sequence-agnostic effects are observed in amoeboflagellate Naegleria gruberi NgTet1 and human TET2. …”
    Journal article
  3. 283

    DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts by Kuś, K, Carrique, L, Kecman, T, Fournier, M, Hassanein, SS, Aydin, E, Kilchert, C, Grimes, JM, Vasiljeva, L

    Published 2025
    “…Xrn2 activity is stimulated by Spt5 to ensure efficient degradation of nascent RNA leading to Pol II dislodgement from DNA. …”
    Journal article
  4. 284

    Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4- iodoamphetamine ((±)-DOI) on cognitive flexibility by Sabanovic, M, Lazari, A, Blanco Pozo, M, Tisca, C, Tachrount, M, Martins Bach, A, Lerch, J, Walton, M, Bannerman, D

    Published 2024
    “…Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. …”
    Journal article
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    The economic burden of rotavirus hospitalization among children < 5 years of age in selected hospitals in Bangladesh by Ahmed, S, Dorin, F, Satter, SM, Sarker, AR, Sultana, M, Gastanaduy, PA, Parashar, U, Tate, JE, Heffelfinger, JD, Gurley, ES, Khan, JAM

    Published 2021
    “…<p><strong>Methods</p></strong> We estimated the societal costs of children <5 years for hospitalization from rotavirus gastroenteritis (RVGE) and incidences of catastrophic health expenditure. …”
    Journal article
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    B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination by Kotagiri, P, Mescia, F, Rae, WM, Bergamaschi, L, Tuong, ZK, Turner, L, Hunter, K, Gerber, PP, Hosmillo, M, Hess, C, Clatworthy, MR, Goodfellow, IG, Matheson, NJ, McKinney, EF, Wills, MR, Gupta, RK, Bradley, JR, Bashford-Rogers, RJM, Lyons, PA, Smith, KGC

    Published 2022
    “…We analyze serial samples from 171 SARS-CoV-2-infected individuals and 63 vaccine recipients and find the global BCR repertoire differs between them. …”
    Journal article
  9. 289

    Effect of Co on twin formation and magnetic properties of Sm(Fe,Ti,V)12 alloys by Tozman, P, Hrkac, G, Patrick, CE, Staunton, JB, Saito, T, Sasaki, T, Ohkubo, T, Sepehri-Amin, H

    Published 2024
    “…Here we have shown that the addition of Co in Sm(Fe<sub>1-x</sub>Co<sub>x</sub>)<sub>10&ndash;11</sub>M<sub>1&ndash;2</sub>&nbsp;alloys, where&nbsp;<em>M</em>=Ti and V, leads to an increase in twin density. Microstructural characterizations revealed that the atomic arrangement in the twin boundary changes depending on the stabilizing element, which directly influences the local intrinsic magnetic properties. …”
    Journal article
  10. 290

    Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England by Copland, E, Patone, M, Saatci, D, Handunnetthi, L, Hirst, J, Hunt, DPJ, Mills, NL, Moss, P, Sheikh, A, Coupland, CAC, Harnden, A, Robertson, C, Hippisley-Cox, J

    Published 2024
    “…In 12-17-year-olds, we estimated 3 (95%CI 0–5) and 5 (95%CI 3–6) additional cases of myocarditis per million following a first and second dose with BNT162b2, respectively. …”
    Journal article
  11. 291

    All-sky search for gravitational wave emission from scalar boson clouds around spinning black holes in LIGO O3 data by Sudhir, Vivishek

    Published 2024
    “…This paper describes the first all-sky search for long-duration, quasimonochromatic gravitational-wave signals emitted by ultralight scalar boson clouds around spinning black holes using data from the third observing run of Advanced LIGO. …”
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