Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

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Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach by Tam, Yew Joon

“…The main results drawn showed that the IEC Q Sepharose XL column and optimum conditions of 4 mL sample loading volume, an elution buffer with 1.5 M NaCl concentration at pH 8 with an elution gradient length of 20 column volume and subsequent purification with SEC at a sample volume of 5 mL and a flow rate of 1 mL/min was able to efficiently purify HBsAg. An up-scaled version the established purification strategy comprising of the two techniques further demonstrated adaptability for scale-up operations with a final total PF of 94.82 ± 16.20, HBsAg purity of 95.48% and recovery yield of 78.07%. …”
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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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大时代小人物的命运: 论新加坡教育改革下华校师生对语言的情意结 = Fate of individuals in a revolutionary era: a study on the language attachment of Chinese school teachers and students under Singapore's education... by 李瑞君 Lee, Rui Jun

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Conformational design characterization of a truncated diamine oxidase by Razali, Nur Nadia

“…By maintaining the native protein’s pH profile, the mini protein was highly active at 40 °C and stable at pH 7, with a half-life of 80 min at 50 °C. Results from the kinetic studies showed that the Km value for native diamine oxidase was 0.274 mM and 1.3 mM for the mini protein. …”
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Tropical peat subsidence, nutrient losses and oil palm seedling growth due to different water table depths by Abubakar, Safiyanu Hashim

“…The system was made of exchange chamber of air pump with the flow rate ranges between 1 and 3.5 L min-1, exchange chamber of (2670 mL plastic container) and a trap (250 mL Erlenmeyer flask). …”
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HiPIMS deposition of VO2 thermochromic coating for enhanced optical properties by Vu, Tuan Duc

“…In chapter 4, a HiPIMS deposition technique for VO2(M) thin film on a commercial material, such as soda-lime glass substrate, was established with a high deposition rate of 5.7 nm/min. The VO2(M) deposited on soda-lime glass exhibits excellent crystallinity and thermochromic properties (highest luminous transmission Tlum ≈ 30.4%, and solar modulation ΔTsol ≈ 12%) in comparison with similarly prepared VO2 on high temperature glass and quartz substrates. …”
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Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…Further application of the PS-MS assay to preclinical pharmacokinetic (PK) study found that, the assay was simple and rapid with overall analysis time of 1 min and a full plasma concentration vs. time profile of sunitinib could be obtained from a single mouse. …”
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Antimicrobial activity, phytochemical and toxicity analyses of salam [Syzygium polyanthum (Wight) Walp.] leaf extract and its application in food by Ramli, Suzita

“…Generally the significant reduction of natural microflora in tested food samples were started at 0.50% (v/v) of extract at 5 min. During storage, 5% (v/v) showed better effect in controlling the microbial survival throughout the storage time. …”
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The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore by Padmapriya, Natarajan, Bernard, Jonathan Y., Tan, Sarah Yi Xuan, Chu, Anne H. Y., Goh, Claire Marie Jie Lin, Tan, Shuen Lin, Shek, Lynette P., Chong, Yap Seng, Tan, Kok Hian, Chan, Shiao-Yng, Yap, Fabian, Godfrey, Keith M., Lee, Yung Seng, Meaney, Michael J., Eriksson, Johan G., Tan, Chuen Seng, Law, Evelyn C., Müller-Riemenschneider, Falk

“…However, higher moderate-to-vigorous PA (MVPA) relative to remaining movement behaviors at age 5.5 years was associated with lower academic achievement [Mean difference (95% confidence interval): −0.367 (−0.726, −0.009) z-score], and reallocating MVPA time to sleep showed higher academic achievement scores [30 min from MVPA to sleep: 0.214 (0.023, 0.404) z-score]. …”
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The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial by Kasturiratne, Anuradhani, Khawaja, Khadija I., Ahmad, Sajjad, Siddiqui, Samreen, Shahzad, Khurram, Athauda, Lathika K., Jayawardena, Ranil, Mahmood, Sara, Muilwijk, Mirthe, Batool, Tayyaba, Burney, Saira, Glover, Matthew, Palaniswamy, Saranya, Bamunuarachchi, Vodathi, Panda, Manju, Madawanarachchi, Suren, Rai, Baldeesh, Sattar, Iqra, Silva, Wnurinham, Waghdhare, Swati, Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Gage, Heather M., van Valkengoed, Irene G. M., Valabhji, Jonathan, Frost, Gary S., Loh, Marie, Wickremasinghe, Ananda R., Kooner, Jaspal S., Katulanda, Prasad, Jha, Sujeet, Chambers, John C.

“…Usual care comprised a single 30-min session of lifestyle modification advice from the community health worker. …”
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits by Evangelou, Evangelos, Warren, Helen R., Mosen-Ansorena, David, Mifsud, Borbala, Pazoki, Raha, Gao, He, Ntritsos, Georgios, Dimou, Niki, Cabrera, Claudia P., Ibrahim Karaman, Ng, Fu Liang, Evangelou, Marina, Witkowska, Katarzyna, Tzanis, Evan, Hellwege, Jacklyn N., Giri, Ayush, Edwards, Digna R. Velez, Sun, Yan V., Cho, Kelly, Gaziano, J. Michael, Wilson, Peter W. F., Tsao, Philip S., Kovesdy, Csaba P., Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Debette, Stéphanie, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G., Jackson, Anne U., Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian'an, Mangino, Massimo, Oldmeadow, Christopher, Prins, Bram Peter, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M., Zhao, Jing-Hua, Amouyel, Philippe, Connell, John, de Mutsert, Renée, Doney, Alex S. F., Farrall, Martin, Menni, Cristina, Morris, Andrew D., Raymond Noordam, Paré, Guillaume, Poulter, Neil R., Shields, Denis C., Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Najaf Amin, Arking, Dan E., Ayers, Kristin L., Barbieri, Caterina M., Batini, Chiara, Bis, Joshua C. M., Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I., Bottinger, Erwin P., Braund, Peter S., Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John Campbell, Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J., Davies, Gail, de Borst, Martin H., de Geus, Eco J., Deary, Ian J., Deelen, Joris, Del Greco M., Fabiola, Demirkale, Cumhur Yusuf, Dörr, Marcus, Ehret, Georg B., Elosua, Roberto, Enroth, Stefan, Erzurumluoglu, A. Mesut, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H., Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J., Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Harris, Sarah E., Hartman, Catharina A., Havulinna, Aki S., Hicks, Andrew A., Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E., Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D., Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D., Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S., Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C. M., Lin, Li, Lind, Lars, Lindgren, Cecilia M., Liu, YongMei, Loos, Ruth J. F., Lopez, Lorna M., Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P., Morrison, Alanna C., Munson, Peter J., Nalls, Mike A., Nandakumar, Priyanka, Nelson, Christopher P., Niiranen, Teemu, Nolte, Ilja M., Nutile, Teresa, Oldehinkel, Albertine J., Oostra, Ben A., O'Reilly, Paul F., Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, Penninx, Brenda W. J. H., Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P., Nguyen, Quang Tri, Raitakari, Olli T., Ren, Meixia, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M., Ried, Janina S., Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M., Rotter, Jerome I., Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F., Salomaa, Veikko, Samani, Nilesh J., Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V., Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M., Stott, David J., Strachan, David P., Strawbridge, Rona J., Sundström, Johan, Swertz, Morris A., Taylor, Kent D., Teumer, Alexander, Tobin, Martin D., Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G., Vaez, Ahmad, van der Most, Peter J., van Duijn, Cornelia M., Vergnaud, Anne-Claire, Verwoert, Germaine C., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H., Willemsen, Gonneke, Wilson, James F., Wright, Alan F., Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R., Butterworth, Adam S., Chasman, Daniel I., Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna M. M., Laakso, Markku, Lakatta, Edward G., Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O., Palmer, Colin N. A., Risch, Lorenz, Scott, Robert A., Scott, Rodney J., Sever, Peter, Spector, Tim D., van der Harst, Pim, Wareham, Nicholas J., Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B., Newton-Cheh, Christopher, Brown, Morris J., Metspalu, Andres, Hung, Adriana M., O'Donnell, Christopher J., Edwards, Todd L., Psaty, Bruce M., Tzoulaki, Ioanna, Barnes, Michael R., Wain, Louise V., Elliott, Paul, Caulfield, Mark J.

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Learning from nature : experimental observation of mimosa pudica by Zhang, Yi

“…Remarkably, the partial pinna stimulation demonstrated a twofold increase in closing time in comparison to entire pinna stimulation, which implied the stimulation contact area did play a significant part in pinna closing time but had no effect on pinna reopening time. …”
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Pipelining digital feedback controllers by Han, Mingli.

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Reversible CO2 activation by an N-phosphinoamidinato digermyne by Quek, Shina

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Review of the research landscape of multi-criteria evaluation and bench- marking processes for many-objective optimisation methods: coherent taxonomy, challenges and recommended so... by Mohammed, R. T., Yaakob, R., Zaidan, A. A., Sharef, N. M., Abdullah, R. H., Zaidan, B. B., Dawood, K. A.

“…Further investigations are required to highlight the limitations of how criteria/metrics are determined and the consistency of the procedures with the evaluation and benchmarking processes of MaOO. A review is conducted in this study to map the research landscape of multi-criteria evaluation and benchmarking processes for MaOO into a coherent taxonomy. …”

Synthesis of porous materials for cooling and gas storage applications by Wong, Shina Si Jing

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Development of a multi-rotor VTOL UAV : numerical study of rotor-wake induced interference drag on a VTOL UAV by Lim, Jarad Jian An

“…Methods for determining the inputs to these MA models are validated, and the MA model is used on a half-body Electric Vertical Take-Off and Landing (eVTOL) aircraft. …”
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Design of the inductive DC-DC buck converter by Lee, Carmen May Yee

“…When buck converter performs at 250kHz with load current of 100mA, the inductor current ripple is about 8.72mA and the output voltage ripple is approximately 35.53mV at the nominal case. …”
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Correlation of recombination and open circuit voltage in planar heterojunction perovskite solar cells by Prochowicz, Daniel, Tavakoli, Mohammad Mahdi, Solanki, Ankur, Goh, Teck Wee, Sum, Tze Chien, Yadav, Pankaj

“…In this study, we employ the state-of-the-art multiple-cation perovskites FA0.83MA0.17Pb(I0.83Br0.17)3 and Cs5(MA0.17FA0.83)95Pb(I0.83Br0.17)3 as absorber layers and investigate their intrinsic and interfacial dynamics in planar TiO2-based PSCs. …”
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