Exploring the induction of preproinsulin-specific Foxp3+ CD4+ Treg cells that inhibit CD8+ T cell-mediated autoimmune diabetes by DNA vaccination by Stifter, Katja, Schuster, Cornelia, Schlosser, Michael, Boehm, Bernhard Otto, Schirmbeck, Reinhold

“…TGF-β expression was significantly enhanced in the Foxp3(+) CD25(+) Treg cell population of vaccinated/ppins-primed mice. Ablation of Treg cells in vaccinated/ppins-primed mice by anti-CD25 antibody treatment abolished the protective effect of the vaccine and enabled diabetes induction by pCI/ppins. …”
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Reverse translational approaches to population neuroimaging: using rodent models to interpret genetic associations with MRI by Tisca, C

“…The genetic similarity between humans and mice means we can measure and compare equivalent phenotypes across species. …”

Dysfunctional cardiac energy transduction, mitochondrial oxidative stress, oncogenic and apoptotic signaling in DiNP-induced asthma in murine model by Kehinde, Samuel Abiodun, Olajide, Abosede Temitope, Fatokun, Tolulope Peter, Faroud, Dalia, Hadi, Najah R., Elgazzar, Ahmed M., James, Adewale Segun, Ashour, Mohamed H. Mazhar

“…In the current study, we assessed the crosstalk between DiNP-induced asthma and cardiac cellular respiration, oxidative stress, apoptotic potential, and induction of oncogenic factors. Ten male BALB/c mice with a weight range of 20–30 g were divided into two groups, each comprising five mice. …”
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Determination of the life span of inflammatory dendritic cells by Tay, Yong Long

“…Due to the lack of a proper Plet-1 knockout mice model previously, cell ablation study of Plet-1+ DCs was not possible. …”
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Experimental studies of melting PCM in a heat sink by Muhammad Azrin Sa'ad.

“…The heat sink design that was the focus of this study is based on the pin finned heat sink design. Experiments mainly pertaining to the characteristics of the melting PCM in the heat sinks were observed and recorded to further understand the behaviours and characteristics of the melting PCM. …”
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Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

“…Finally, treatment with another PPARβ/δ agonist increased VLDLR levels in the liver of wild-type mice, but not PPARβ/δ-deficient mice, confirming the regulation of hepatic VLDLR by this nuclear receptor. …”
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Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4- iodoamphetamine ((±)-DOI) on cognitive flexibility by Sabanovic, M, Lazari, A, Blanco Pozo, M, Tisca, C, Tachrount, M, Martins Bach, A, Lerch, J, Walton, M, Bannerman, D

“…Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. …”

Investigation of the effects of Anti-Müllerian Hormone on preventing Doxorubicin-induced primordial follicle loss by Wei, X

“…Follicular damage caused by DXR was also demonstrated in adult mouse ovaries in vivo but not in human pre-pubertal ovarian tissue xenotransplanted into mice. Although there were trends, there was no significant effect of AMH treatment alone on inhibiting primordial follicle activation in mouse ovarian tissue (in vitro and in vivo) or human ovarian tissue (xenotransplanted into mice). …”

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. Results The PPARβ/δ agonist GW501516 prevented lipid-induced ER stress in mouse and human myotubes and in skeletal muscle of mice fed a high-fat diet. …”
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Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…Notably, when the IB-treated mice were subsequently re-challenged with CT26 cells, the immune mediated-response prevented the establishment of a second tumor in the mice. …”
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Hybrid biometric authentication for automatic teller machine by Arokiasamy, Steven R., Tomal, Md Raihanul Islam, Moorthy, Kohbalan, Mohd Daud, Kauthar

“…Unlike traditional password or PIN-based methods, biometric authentication uses unique physical characteristics, such as fingerprints, to verify identity. …”
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Security enhancement for domain name system in the internet by Narayanan Arjun

“…Domain Name System (DNS) can be referred as the spine of today’s Internet world. This system is completely responsible for providing an architecture that helps in resolving millions of domain names existing throughout the world to a unique IP address, enabling the users to access the domains from anywhere on the planet. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Chapter 4 focuses on the site-specific glycosylation occupancy, and N- and O-glycan structures attached to virion derived SARS-CoV-2 spike glycoproteins. This glycan signature was compared to a stabilised prefusion trimeric spike, to a monomeric subunit of spike (S1) and to an antigen of a non-stabilised vaccine candidate, revealing subunit shedding of the S1 glycoprotein for the vaccine candidate. …”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…However, only the LRR-specific mAbs increased the number of action potential firing together with enhanced initial instantaneous frequency and promoted spike-frequency adaptation, which were less pronounced after the EPTP mAb. …”

Design of a dual band planar inverted-F antenna for GMS/DCS mobile handset by Fang, Jun

“…This project involved the study of size miniaturization of microstrip antenna techniques: shorting pin and shorting wall, loading, shorted spiral printed antenna and stacked shorted patch antenna are fully discussed.…”
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Study on the wear characteristics of aluminium metal matrix composite with 15% Al2O3 and 20% Al2O3 by Chua, Swu Chun.

“…The objective of this dissertation was to study the wear characteristics and behaviour of aluminium metal matrix composite materials (MMCs), namely Duralcan 286 and Duralcan 284 as a pin material when mated against three types of dics materials.…”
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OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy by Zeng, Yong, Gao, Shasha, Li, Yichao, Marangoni, Dario, De Silva, Tharindu, Wong, Wai T., Chew, Emily Y., Sun, Xun, Li, Tiansen, Sieving, Paul A., Qian, Haohua

“…Gene replacement therapy in Rs1KO mice reverted the ORB pattern to one resembling WT and increased the Dip ratio. …”
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Microcrystalline Tyrosine (MCT®): a depot adjuvant in licensed allergy immunotherapy offers new opportunities in malaria by Cabral-Miranda, G, Heath, MD, Gomes, AC, Mohsen, MO, Montoya-Diaz, E, Salman, AM, Atcheson, E, Skinner, MA, Kramer, MF, Reyes-Sandoval, A, Bachmann, MF

“…Both MCT and Alum strongly increased immunogenicity of CSP compared to PBS in both C57BL/6 and BALB/c mice. Challenge studies in mice using a chimeric <em>P. bergei</em> expressing CSP of <em>P. vivax</em> demonstrated clinically improved symptoms of malaria with CSP formulated in both MCT and Alum; protection was, however, more pronounced if CSP was formulated in MCT. …”

Range expansion of a declining forest species, the Western Gray Squirrel (Sciurus griseus), into semi-arid woodland by Sultaire, SM, Montgomery, RA, Jackson, PJ, Millspaugh, JJ

“…Occupancy modeling revealed that western gray squirrels were equally likely to occur in piñon–juniper woodland compared to mature pine forest that they occupy elsewhere in their range. …”

Design of an exoskeleton for lifting by Lim, Ernest Zhen Xuan

“…Lower back injuries, caused by muscle strain around the lumber spine, are common in work involving manual labour. …”
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