Focused array analysis of diabetic skin wound. by Ling, Wei Yin.

“…To understand the interplay among these players behind angiogenesis and discover possible therapeutic targets, a focused array approach employing real-time quantitative PCR technique was used to unravel the differential gene molecular profiles in the healing of chronic diabetic mice wounds compared to that of normal wounds. In vivo analyses using wildtype (+/+) and diabetic (ob/ob) mice wounds revealed many angiogenic factors and inflammatory mediators with altered gene expression patterns and levels leading to the chronic inflamed state of diabetic wounds. …”
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In vivo visualization of cells with fluorescent-labeled fab fragment. by Wee, Armanda Lixuan.

“…However, the current use of fluorescent reporter mice and fluorescent-labeled antibodies are accompanied with several limitations that restricts their usefulness for in vivo imaging. …”
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Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome by Alford, KA, Slender, A, Vanes, L, Li, Z, Fisher, EMC, Nizetic, D, Orkin, SH, Roberts, I, Tybulewicz, VLJ

“…We show that although Tc1 mice do not develop leukemia, they have macrocytic anemia and increased extramedullary hematopoiesis. …”

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Increased Fgf21 expression was observed in liver of PPARβ/δ-null mice and in mouse primary hepatocytes when this receptor was knocked down by small interfering RNA (siRNA). …”
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The role of calcium dependent neurotransmission in axon path finding, myelination and maintenance of specified cortical projection neuron populations by Korrell, K

“…</p> <p>Together, the results indicate that neuronal activity has little effect on the onset of myelination but has effects on the g-ratio in deep cortical layer projection neurons in mice.</p>…”

The response of Pinus caribaea mor. var. Hondurensis seedlings to nitrogen, phosphorous and potassium fertilizers by Srivastava, P.B.L., Naruddin, Abang, Zainorin, B.Abang

“…For this purpose, seedlings were grown in plastic pots in soils collected from Bahau pine experimental area. These soils belong to Durian series and are generally poor in nutrients. …”
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Synaptic CMOS transistor by Chai, Zhen Hong

“…In this work, electrical measurements were conducted on commercial level TiN/HfO2 gated n-channel MOSFET transistor (with an equivalent oxide thickness of 1.7nm) to demonstrate that it can exhibit some critical synaptic characteristics of a biological synapse such as excitatory and inhibitory postsynaptic current (EPSC and IPSC), short-term plasticity (STP) and long-term potentiation (LTP), metaplasticity, and spike timing dependent plasticity (STDP). The mechanism behind the output characteristic of MOSFET to exhibit synaptic-like response is the charge trapping and de-trapping at defects in the oxide and oxide/semiconductor interface. …”
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A scalable variational inference approach for increased mixed-model association power by Loya, H, Kalantzis, G, Cooper, F, Palamara, PF

“…We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. …”

Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains by Huang, Helen Xuexia, Inglese, Paolo, Tang, Jiabin, Yagoubi, Riad, Correia, Gonçalo D. S., Horneffer-van der Sluis, Verena M., Camuzeaux, Stephane, Wu, Vincen, Kopanitsa, Maksym V., Willumsen, Nanet, Jackson, Johanna S., Barron, Anna M., Saito, Takashi, Saido, Takaomi C., Gentlemen, Steve, Takats, Zoltan, Matthews, Paul M.

“…To delineate the pathological correlations of distinct lipid species, we conducted a comprehensive characterization of both spatially localized and global differences in brain lipid composition in AppNL-G-F mice with spatial and bulk mass spectrometry lipidomic profiling, using human amyloid-expressing (h-Aβ) and WT mouse brains controls. …”
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Enhanced restoration of visual code after targeting ON bipolar cells compared to retinal ganglion cells with optogenetic therapy by Rogers, J, Hughes, S, Ebrahimi, A, Allen, A, Storchi, R, Lindner, M, Peirson, S, Badea, T, Hankins, M, Lucas, R

“…Our data show that, while both approaches restore visual responses with impressive fidelity, ON BC targeting produces a richer visual code closer to that of wild-type mice. …”

Strong immune responses and robust protection following a novel protein in adjuvant tuberculosis vaccine candidate by Korompis, M, De Voss, CJ, Li, S, Richard, A, Almujri, SS, Ateere, A, Frank, G, Lemoine, C, McShane, H, Stylianou, E

“…Vaccinated mice had enriched lung parenchymal antigen-specific CD4 + CXCR3 + KLRG1− T cells previously associated with TB protection. …”

Finite element analysis on post-buckling of thin-walled structures using ANSYS by Theint, Yi Mon

“…The results obtained were checked against experimental data and led to the development and the revision of design procedures for the pin-ended lipped column and hollow box section.…”
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Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell-selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. …”
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Dengue death rate higher among women than men in Bangladesh by Roney, Miah, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Given the atypical seasonality of the epidemic and the sudden spike in cases early on, it is noteworthy that mosquito and potential hotspot densities were at an all-time high throughout the previous years.…”
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Design and development of extreme learning machine symposium web portal by Chiang, Yu Hui.

“…In recent years, it has been observed that there is a spike in interest in the development of web based conference management systems. …”
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Mean-field approximation for networks with synchrony-driven adaptive coupling by Fennelly, N, Neff, A, Lambiotte, R, Keane, A, Byrne, A

“…In place of the less tractable spike-timing-dependent plasticity, we employ recently validated phase-difference-dependent plasticity rules, which adjust coupling strengths based on the relative phases of θ-neuron oscillators. …”

中朝古代桃花源文学比较研究 = A comparative study of peach blossom literature in ancient China and Korea by 蔡佳敏 Cai, Jiamin

“…This peach blossom imagery develops from Tao Yuan Ming's portrayal of a peach blossom in his famous poetry "The Peach Colony" ("Tao Hua Yuan Shi with Ji"). …”
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Sympathetic-neuron-derived neuropeptide Y (NPY) regulates adipose tissue immunometabolic homeostasis by Zhu, Y

“…This defect is replicated in conditional knockout (cKO) mice with NPY specifically abrogated from sympathetic neurons. …”

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Raj Murthi, S, Petry, A, Shashikadze, B, Stöckl, JB, Schmid, M, Santamaria, G, Klingel, K, Kračun, D, Chen, X, Bauer, S, Schmitt, JP, Flenkenthaler, F, Gorham, J, Toepfer, CN, Potěšil, D, Hruška, P, Zdráhal, Z, Mayer, Z, Klop, M, Lehmann, L, Qin, Y, Papanakli, L, Spielmann, N, Moretti, A

“…The results show that Hif-1α protein and HIF targets were upregulated in left ventricular tissue of α-MHC719/+ mice. Cardiomyocyte-specific abolishment of Hif-1a blunted the disease phenotype, as evidenced by decreased left ventricular wall thickness, reduced myocardial fibrosis, disordered SRX/DRX state and ROS production. cHif1aKO induced normalization of pro-hypertrophic and pro-fibrotic left ventricular remodeling signaling evidenced on whole transcriptome and proteomics analysis in α-MHC719/+ mice. …”

Cross-modal size-contrast illusion : acoustic increases in intensity and bandwidth modulate haptic representation of object size by Uesaki, Maiko, Ashida, Hiroshi, Kitaoka, Akiyoshi, Pasqualotto, Achille

“…In this study, a series of images each comprising a pair of pine-tree figures were translated into auditory modality using sensory substitution software. …”
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