Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
Get full text

Engineering Mechanical Counter Pressure Spacesuits and Compression Garments: Active Pressurization and Design for Mobility by Kothakonda, Akshay

“…The process of estimating the optimum fabric pattern will be iterative and the resulting pattern may comprise of a composite of different fabric types with varying parameters. Mapping skin Lines of Non-Extension (LoNE’s) informs contours for inextensible cables in such a way that they do not impede movements. …”
Get full text

Content-based image retrieval with statistical machine learning. by Zhang, Lining.

Get full text

Investigating the neural substrates of Chinese character processing by Wu, Chiao-Yi

“…The research framework consisted of two levels: direct and converging evidence, through three lines of investigations. Study 1 and Study 2 provided direct evidence of the neural mechanisms for Chinese character processing. …”
Get full text

Instrumentation optimisation for unicompartmental knee replacement by Arthur, LW

“…Cementless OUKRs (1/15) had fewer tibial radiolucent lines compared to cemented (6/14) at 10 years.</p> <p>Bearing fractures, because of excessive polyethylene wear, have been reported with the Phase III OUKR. …”

ESBL and AmpC β-lactamase encoding genes in E. coli from pig and pig farm workers in Vietnam and their association with mobile genetic elements by Hounmanou, Yaovi Mahuton Gildas, Bortolaia, Valeria, Dang, Son Thi Thanh, Truong, Duong, Olsen, John E., Dalsgaard, Anders

“…The isolates carrying the plasmids, even those with plasmids of similar types, showed wide genetic variation with high number of SNPs, suggesting horizontal spread of plasmids into different clonal lines. Their virulence profiles did not confirm to known pathotypes, suggesting that unrelated commensals are a main reservoir for ESBL and AmpC β-lactamases in both humans and pigs. …”
Get full text

Artificial Intelligence in HCI : Second International Conference, AI-HCI 2021, held as part of the 23rd HCI International Conference, HCII 2021, Virtual event, July 24-29, 2021, Pr... by AI-HCI (Conference) (2nd : 2021 : Online), organiser 642919, Degen, Helmut, 1964-, editor 642920, Ntoa, Stavroula, editor 642921, International Conference on Human-Computer Interaction (23rd : 2021 : Online), organiser 642922

Carbon nanotube fence-wall for radio frequency isolation by Tan, Dunlin

“…Passive structures made of microstrip lines and via-fences were first designed using Ansys full wave solver HFSS. …”
Get full text

Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells by Xing, X., Huang, L., Li, X., Li, Z., Zhou, W., Tian, L., Chen, J., Chen, C., Ma, Xing, Yang, Z.

“…And then, we established the stable transfected cell lines. Next, after CVB3 infection, apoptosis in different groups was determined by flow cytometry; the expressions of Bim, Bax, caspase-9 and caspase-3 were examined by real-time fluorescence quantitative PCR and western blot analysis; the expression of CVB3 mRNA and viral capsid protein VP1 were also analyzed by real-time fluorescence quantitative PCR, western blot analysis and immunofluorescence, respectively. …”
Get full text
Get full text

Space charge induced beam loss on a high intensity proton synchrotron by Pine, B

“…Beam will be lost on injection to a synchrotron and may be lost on extraction or in transfer lines. Non-linearities in the accelerator lattice can introduce driving terms for resonant beam behaviour. …”

Data driven and learning based approaches for integrated landside airside operations optimization by Ali, Hasnain

“…Results show that the chances of missed connections can be significantly reduced by operationally maintaining higher turnaround time and minimum connection time and by bringing down delays at the airport. Specifically, by maintaining the flight turnaround time at 50 minutes, minimum connection time at 60 minutes and by containing arrival delays within 70% of the current delay spread at Singapore Changi Airport Terminal 4, transfer passenger missed connections can be prevented for almost all the flights. …”
Get full text

A combined numerical and experimental approach to investigations of body-freedom flutter on flying wings by Ang, Elijah Hao Wei

“…In such scenarios, the fuselage cannot be assumed to be fixed, and rigid-body modes have to be considered. Hence, this brings about a need for a new methodology to flutter investigations, as conventional methods used in the past may not be applicable to flying wings undergoing BFF. …”
Get full text

探究游戏主题曲的歌曲字幕翻译策略 —— 以《英雄联盟》2023年全球总决赛主题曲 《GODS登神》为例 = Subtitling strategies for game theme song —— taking league of legends 2023 global finals theme song “GODS” as example... by 黄裕惠 Wong, Rebecca Yu Hui

“…On the other hand, Bilibili's translated subtitles utilizes methods such as free translation and adaptation, conveying the general meaning of the lyrics while bringing out the themes of the song and the content of the game, it also retains the musicality, making the translation harmonious and helping to resonate with the player community. …”
Get full text

Evaluating the socio-environmental impacts of monoculture cashew expansion in the Northern Western Ghats, India by Anushka Rege

“…Research along such socio-environmental lines can possibly contribute to the development of sustainability and certification initiatives for cashew. …”
Get full text

Extreme learning machines for feature learning by Liyanaarachchi Lekamalage, Chamara Kasun

“…Hierarchal features consist of multiple levels and the low level features represent edges of an image such as lines and curves while high level features represent parts of the image such as nose, eyes of a face. …”
Get full text

Unsupervised bayesian generative methods by Li, Shaohua

“…This finding bridges the two very different lines of model selection methods. The third task is about Word Embedding, a technique that maps words in a natural language to continuous vectors which encode the semantic/syntactic regularities among the words. …”
Get full text

Next generation design of floating systems for coastal solar farms by Bi, Cheng

“…Experiments on a novel adaptive barrier-mooring system (ABMS) including perimeter pontoons, submerged barriers, clump weights, mooring lines and anchors were conducted to examine the adaptivity of ABMS to a large tidal range as well as its performance on platform stabilization under wave action. …”
Get full text

Antidiabetic activity of Curculigo latifolia extracts in vitro and in vivo studies by Ishak, Nur Akmal

“…In the present study, antidiabetic properties of C. latifolia in cell lines (in vitro) and in diabetic-induced rats were determined. …”
Get full text

Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…We used host gene expression signatures of cell lines from three species (A549 (human), CEF (chicken), and MDCK (canine) in response to six IAVs (H1N1/WSN, H5N2/F59, H5N2/F118, H5N2/F189, H5N3 and H9N2 viruses). …”
Get full text

Tsewang Norbu NGB by Cantwell, C, Mayer, R

“…Thanks to Sam van Schaik and Burkhard Quessel of the British Library for bringing to our attention the location of these two title folios. …”