Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…Simplification of complex medication regimens in polypharmacy positively contributes to treatment adherence and cost‐effective improved health outcomes. …”
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De l'arme de guerre à l'objet de collection. Une histoire matérielle des canons français d’Ancien Régime au Musée royal de Mariemont (XVIIIe-XXIe siècles) by Depreter, M

The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean

“…A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. …”
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Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses by Chauffour, Aurélie, Robert, Jérôme, Veziris, Nicolas, Aubry, Alexandra, Pethe, Kevin, Jarlier, Vincent

“…An intermittent oral regimen would facilitate treatment supervision. We first evaluated the bactericidal activity of newer antimicrobials against M. ulcerans using a BU animal model. …”
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A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border by Ansari, AT, Aung, KK, Win, HH, Beau, C, Nu, B, Soe, NL, Htoo, K, San, T, Wah, TG, Keereevijit, A, Phyo, AP, Chotivanich, K, White, NJ, Nosten, F, Hashmi, AH, Chu, CS

“…Understanding and facilitating adherence to primaquine radical cure regimens is necessary for malaria elimination. Methods: A convergent parallel mixed methods study was conducted to investigate the barriers to and facilitators for completing primaquine treatment of P. vivax infection among mobile migrant communities on the Myanmar-Thailand border. …”

Overall survival by IDH2 mutant allele (R140 or R172) in patients with late-stage mutant- IDH2 relapsed or refractory acute myeloid leukemia treated with enasidenib or conventional care regimens in the phase 3 IDHENTIFY trial by De Botton, S, Risueño, A, Schuh, AC, Lowenberg, B, Kim, H-J, Vyas, P, Wei, AH, Stein, EM, Dohner, H, Fathi, AT, Dinardo, CD, Martin Regueira, P, Taningco, L, Bluemmert, I, Yu, X, See, WL, Hasan, M

Role of different dendritic cell subsets in vivo by Abdul Rashid Mohammad Muzaki

“…In a dextran sodium sulphate (DSS) model of colonic inflammation, ablation of CD103+ CD11b- colonic DCs resulted in exacerbated colitis, while ablation of colonic CD103+ CD11b+ DCs resulted in resistance to colitis when subjected to the same DSS regiment. Hence our results highlight the opposing roles of these two distinct colonic DC subsets in controlling DSS-induced colonic inflammation. …”
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Novel viral vector vaccines for tropical infections by Rampling, T

“…Two studies evaluate the safety, efficacy and immunogenicity of a combination vaccination regimen containing the leading pre- erythrocytic <em>P. falciparum</em> malaria vaccine RTS,S/AS01B and the liver stage, viral vector heterologous prime-boost regimen of ChAd63 ME-TRAP and MVA ME-TRAP. …”

The effect of early age feed restriction on subsequent response to high environmental temperatures in female broiler chickens by Zulkifli, I., Che Norma, M.T., Israf, D.A., Omar, A.R.

“…On Day 0, chicks were assigned to one of four feeding regimens; each regimen was applied to four cages of chicks. …”
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Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…In each regime, we determine the biological processes that may underpin positive and negative treatment outcomes and assess which treatment (RT, HT or RT + HT) and dosing regimen maximise the reduction in tumour burden. …”

Smuggling of Migrants in Malaysia: The Case Study of Illegal Immigrants in the Northern Region by Ajis, Mohd Na'eim, Ahmad Zakuan, Ummu Atiyah, Mohd. Zain, Zawiyah, Keling, Mohamad Faisol

“…Relevant authorities like Malaysian Maritime Enforcement Agency, Malaysia Immigration Department and Border Ranger Regiment, are being interviewed. Findings reveal that the activities of migrant smuggling are occurring in the Northern Region of the Peninsular Malaysia. …”
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Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…Children received either 10 μg RH5.1 at 0, 1, and 2 months (Children 10M) or 10 μg RH5.1 at 0, 1, and 6 months (delayed third dose regimen; Children 10D), and were recruited in parallel, followed by children who received the dose-escalation regimen (Children DFx) and children with higher malaria pre-exposure who also received the dose-escalation regimen (High Children DFx). …”

Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens by Barrett, JR, Silk, SE, Mkindi, CG, Kwiatkowska, KM, Hou, MM, Lias, AM, Kalinga, WF, Mtaka, IM, McHugh, K, Bardelli, M, Davies, H, King, LDW, Edwards, NJ, Chauhan, VS, Mukherjee, P, Rwezaula, S, Chitnis, CE, Olotu, AI, Minassian, AM, Draper, SJ, Nielsen, CM

“…In contrast, the CD4+ and CD8+ T cell responses were impacted by vaccine platform but not dosing regimen and did not correlate with in vivo growth inhibition in a challenge model. …”

Modelling the rheology of living cell cytoplasm: poroviscoelasticity and fluid-to-solid transition by Thekkethil, Namshad, Köry, Jakub, Guo, Ming, Stewart, Peter S., Hill, Nicholas A., Luo, Xiaoyu

“…Baseline simulations (neglecting the viscosity of the cytosol) indicate that the system exhibits seven different regimes across the parameter space spanned by the viscoelastic relaxation timescale of the cytoskeleton and the poroelastic diffusion timescale; these regimes agree qualitatively with experimental measurements. …”
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An investigation of friction-based tendon sheath model appropriate for control purposes by Tjahjowidodo, Tegoeh, Lau, Michael Wai Shing, Phee, Soo Jay, Do, T. N.

“…A new dynamic friction model that allows accurate description of friction lag and hysteresis behavior in two regimes, i.e. presliding and sliding regimes, for a sheath in arbitrary configuration such as helical and spatial shape has been developed. …”
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Asymptotic analysis of deep residual networks by Cont, R, Rossier, A, Xu, R

“…We first show the existence of scaling regimes for trained weights markedly different from those implicitly assumed in the neural ODE literature. …”

The impact of evolving SARS-CoV-2 mutations and variants on COVID-19 vaccines by McLean, Gary R., Kamil, Jeremy, Lee, Benhur, Moore, Penny, Schulz, Thomas F., Muik, Alexander, Sahin, Ugur, Tureci, Ozlem, Pather, Shanti

“…Although data on the effectiveness of the primary regimen against omicron (B.1.1.529) are limited, booster programs using mRNA vaccines have been shown to restore protection against infection and symptomatic disease (regardless of the vaccine used for the primary regimen) and maintain high effectiveness against hospitalization. …”
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Deliberation in the Russian state Duma: from a seat of discussion to a tool of autocracy, 1996-2021 by James, N

“…Why do legislators continue to engage in parliamentary floor activities under authoritarian regimes when policy decisions and voting outcomes are often predetermined before reaching the debate stage? …”

The four worlds of ‘welfare reality’ – social risks and outcomes in Europe by Ferragina, E, Seeleib-Kaiser, M, Spreckelsen, T

“…After three decades of welfare state crisis, change and transformation can we still speak of welfare state regimes when looking at their outcomes? The analysis of outcomes provides a picture of ‘the real worlds of welfare’ and is of considerable importance to understanding political legitimacy across countries. …”

Spontaneous Symmetry Breaking in a Polariton and Photon Laser by Ohadi, H., Kammann, E., Liew, Timothy Chi Hin, Lagoudakis, K. G., Kavokin, A. V., Lagoudakis, P. G.

“…We report on the simultaneous observation of spontaneous symmetry breaking and long-range spatial coherence both in the strong- and the weak-coupling regime in a semiconductor microcavity. Under pulsed excitation, the formation of a stochastic order parameter is observed in polariton and photon lasing regimes. …”
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