Rail transit OD matrix estimation and journey time reliability metrics using automated fare data by Chan, Joanne, S.M. Massachusetts Institute of Technology

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A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53 by Wong, Jin Huei, Alfatah, Mohammad, Sin, Mei Fang, Sim, Hong May, Verma, Chandra Shekhar, Lane, David P., Arumugam, Prakash

“…In addition, we identified a conserved segment in the core DNA-binding domain of p53 that facilitates stable interaction with Mdm2 in yeast cells and in vitro. …”
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Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…In addition, mutagenesis and structural studies unveiled an allosteric site, termed the 'DEK' (encompassing the key structural elements DFG motif, Glu315 on the αC helix, and kinase inhibitory segment), crucial in modulating kinase activity.</p> <p>To gain a deeper understanding of the action mechanism underlying PAK1 small molecule activators, fluorescence resonance energy transfer (FRET), superresolution single molecular imaging, and mass photometry were applied to illustrate the conformational changes and alterations in PAK1 dimerization upon the binding of small molecule activators. …”

Robust deep learning methods for accountable contrast-agent-free CMR imaging in clinical applications by Gonzales, RA

“…This approach reduced inter-observer variability and improved the consistency of myocardial segmentation.</p> <br> <p>The fourth goal is to assist the automated segmentation of CMR short-axis slices into the American Heart Association 16-segment model for clinical applications across various CMR modalities. …”

Spatiotemporal signatures of elastoinertial turbulence in viscoelastic planar jets by Yamani, Sami, Raj, Yashasvi, Zaki, Tamer A., McKinley, Gareth H., Bischofberger, Irmgard

“…We show how fluid elasticity has a nonmonotonic effect on the jet stability depending on its magnitude, creating two distinct regimes in which elastic effects can either destabilize or stabilize the jet. …”
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Understanding Drivers of Deforestation using Games on Spatial Networks by Seby, Jean-Baptiste

“…Interestingly, we identify a regime shift (or phase transition) as the local network effect and level of coupling between activities vary. …”
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Imaging the wakes of jets with energy-energy-energy correlators by Bossi, Hannah, Kudinoor, Arjun S., Moult, Ian, Pablos, Daniel, Rai, Ananya, Rajagopal, Krishna

“…We find that hadrons originating from wakes are the dominant contribution to the three-point correlator in the kinematic regime in which the three points are well-separated in angle, forming a roughly equilateral triangle. …”
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100 THz optical switching with plasmonic metamaterial by Venkatram, Nalla, Stefano, Vezzol, João, Valente, Sun, Handong, Nikolay, Zheludev

“…Finally we evaluate the effect of non linearities, showing that the best coherent modulation is obtained in a very low power regime. We also evaluate the wavelength dependent coherent modulation; maximum modulation is at plasmonic peak.…”
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A reformulation of additive models by Wozniakowski, Alex

“…Yet, the traditional methodology neglects the means to explicitly incorporate prior knowledge into the fit of an additive model, which is of great practical importance in regression tasks, especially in the low training example regime, where entirely data-driven learning is not always feasible. …”
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Electrical characterization of bias temperature instability in MOSFETs with the ultrathin SiON and la-doped HfSiO gate dielectrics by Du, Guoan.

“…Under certain stress voltage and temperature, the number of E'δ centers is saturated because the reaction of pre-existing oxygen vacancies at shallow regime reaches its dynamic balance. On the other hand, lengthening of the stress time allows the generation of deeper hole trap states arising greater structural relaxation through increased interaction with lattice phonons. …”
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Modeling, optimization and thermal characterization of micropillar evaporator based high performance silicon vapor chamber by Wei, Mengyao

“…Investigation on wettability performance of micropillar structures was not systematically extended to a high temperature regime. In this thesis, we developed three semi-analytical models in predicting the capillary-limited dryout heat flux of uniform evaporators, biporous evaporators and sealed silicon vapor chambers. …”
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The divergent fates of primitive hydrospheric water on Earth and Mars by Wade, Jon, Dyck, Brendan, Palin, Richard M., Moore, James Daniel Paul, Smye, Andrew J.

“…This would have allowed efficient overplating and burial of early Martian crust in a stagnant-lid tectonic regime, in which the lithosphere comprised a single tectonic plate, with only the warmer, lower crust involved in mantle convection. …”
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Performance of epoxy-based self-healing mortar by Ariffin, Nur Farhayu

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Localization and motion planning of mobile robots by Dai, Yunxiang

“…Afterward, a novel reference path segment generation and switching mechanism are proposed to bridge the perception with the low-level controller. …”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The MtRel NTD in the presence of TGS domain showed almost similar synthetic activity as of MtRel NTD and approximately 3 fold higher than that of MtRel showing auto-inhibition by rest of the C-terminus MtRel segment. The MtRel ACT structure was determined as a dimer and the oligomeric state was further confirmed using SAXS. …”
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Associations between health literacy and health care utilization and mortality in patients with coexisting diabetes and end-stage renal disease : a prospective cohort study by Griva, Konstantina, Loong, Russel K. L., Nandakumar, Mooppil, Rajeswari, Moothathamby, Khoo, Eric Y. H., Lee, Vanessa Y. W., Kang, Augustine W. C., Osborne, Richard H., Brini, Stefano, Newman, Stanton P.

“…Patients with diabetes (DM) comprise the fastest growing segment of patients with end-stage renal disease (ESRD). …”
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Codesign of quantum error-correcting codes and modular chiplets in the presence of defects by Lin, Sophia Fuhui, Viszlai, Joshua, Smith, Kaitlin N., Ravi, Gokul Subramanian, Yuan, Charles, Chong, Frederic T., Brown, Benjamin J.

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Prediction of stable perovskite quantum dots (QDs) using machine learning (ML) algorithms by Cheong, Ivan

“…However, they have not been widely studied, with applications limited to solar cells and catalytic activity, the full extent of possible applications are yet to be realised. At the nano regime the properties are often different and can be controlled, this is due to quantum confinement and larger surface to volume ratio, which can be adjusted by controlling the size, subsequently able to use for various application. …”
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Theoretical study on forced convection filmwise condensation inside converging channels in the presence of a non-condensable gas by Liu, Pengfei, Ho, Jin Yao, Kandasamy, Ranjith, Wong, Teck Neng

“…When the air mass fraction is high (W=0.4), the enhancement ratio appears to be insensitive to the Reynolds number in the laminar and turbulent regime, respectively. In addition, the enhancement ratio generally increases as the air mass fraction increases.…”
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Bond strength and tension stiffening of fly ash geopolymer concrete by Salem, Hamdi Abdulrahman Saif

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