Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

“…Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. …”
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Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…<p>The COVID-19 pandemic, caused by SARS-CoV-2, has profoundly impacted global health, prompting extensive research into vaccine responses and the immune dynamics of SARS-CoV2 variants of concern (VOCs). …”

Detecting changes in population trends in infection surveillance using community SARS-CoV-2 prevalence as an exemplar by Pritchard, E, Vihta, K-D, Eyre, DW, Hopkins, S, Peto, TEA, Matthews, PC, Stoesser, N, Studley, R, Rourke, E, Diamond, I, Pouwels, KB, Walker, AS, COVID-19 Infection Survey Team

“…Substantial changes in SARS-CoV-2 prevalence with emergence of variants provides opportunity to investigate different methods to do this. …”

A systems biology approach to define SARS-CoV-2 correlates of protection in non-human primates by Brady, C

“…SARS-CoV-2 is expected to become a seasonal human coronavirus, with annual vaccination advised for vulnerable populations, similar to influenza. …”

Chronic neuropsychiatric sequelae of SARS-CoV-2: protocol and methods from the Alzheimer's Association Global Consortium by de Erausquin, GA, Snyder, H, Brugha, TS, Newton, C

“…No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). …”

CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment by Greensmith, Robert, Lape, Isadora T., Riella, Cristian V., Schubert, Alexander J., Metzger, Jakob J., Dighe, Anand S., Tan, Xiao, Hemmer, Bernhard, Rau, Josefine, Wendlinger, Sarah, Diederich, Nora, Schütz, Anja, Riella, Leonardo V.

“…However, current methods, relying on hybridization or sequencing, are unsuitable for point-of-care settings. In contrast, CRISPR-based-diagnostics offer high sensitivity and specificity for point-of-care applications. …”
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Team learning : the link between caring working relationships, learning behaviors and knowledge. by Phua, Mary Bee Ling., Wong, Yvonne Wanling., Tan, Jacqueline Si Ying.

“…This study explores the link between caring working relationships, learning behaviors and knowledge. …”
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Pet loss in Singapore: understanding anticipatory grief and the role of advance care planning by Harindran, Ravin

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Person-centred care for dementia patients (back-end and front-end development) by Leow, Mandfred Hong Jie

“…This report documents the development and transition of the Person-Centred Care System (PEAR) from a monolithic .NET 5-based application to a microservices architecture with ReactJS for the front end. …”
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Creation of a world class manufacturing system in a health-care company by Tay, Albert Kim Chuan.

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Automated mean arterial pressure control for postoperative patients in intensive care conditions by Ma, Jie

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The fate and transformation of pharmaceutical and personal care products in wastewater treatment plants – (ii) by Ng, Thai Yeng

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Pear person-centred care for dementia patients (front end Android app) by Ng, Jian Xiong

“…With so much emphasis placed on the individualism of eachpatient, this could stress out the caregivers in a care centre. To reduce the workload on the caregiver, technology could play apart and give rise to more effective healthcare services.In this project, a Person-Centred Care system was created to assist the caregivers who were responsible for taking care of their patients and increasing the efficiency of dementia care in a care centre. …”
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Improving clinical care of patients in Nipah outbreaks: moving beyond 'compassionate use' by Hassan, MZ, Rojek, A, Olliaro, P, Horby, P

“…Current care relies on supportive measures and the ‘compassionate use’ of unapproved drugs like ribavirin and remdesivir. …”

Investigating the health and care needs of pregnant women with multiple long-term conditions by D'Arcy, R

Sharing is caring? International Society for Pharmacoepidemiology review and recommendations for sharing programming code by Tazare, J, Wang, SV, Gini, R, Prieto Alhambra, D, Arlett, P, Morales Leaver, DR, Morton, C, Logie, J, Popovic, J, Donegan, K, Schneeweiss, S, Douglas, I, Schultze, A

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…We address this gap by integrating large-scale primary-care and genetic data from multiple studies to interrogate multimorbidity patterns and producing digital resources to support future research.…”

Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility by Cheng, Hui Mei, Zhao, Xiahong, Lim, Wei Shyann, Tan, Beatrice Jia Min, Tey, Hong Liang

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Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals by Goh, Yun Shan, Rouers, Angeline, Fong, Siew-Wai, Zhuo, Nicole Ziyi, Hor, Pei Xiang, Loh, Chiew Yee, Huang, Yuling, Neo, Vanessa Kexin, Kam, Isaac Kai Jie, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Lee, Raphael Tze Chuen, Pada, Surinder, Sun, Louisa Jin, Ong, Desmond Luan Seng, Somani, Jyoti, Lee, Eng Sing, Maurer-Stroh, Sebastian, Wang, Cheng-I., Leo, Yee Sin, Ren, Ee Chee, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

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Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3... by Poh, Xuan Ying, Lee, I. Russel, Lim, Clarissa, Teo, Jefanie, Rao, Suma, Chia, Po Ying, Ong, Sean W. X., Lee, Tau Hong, Lin, Ray J. H., Ng, Lisa F. P., Ren, Ee Chee, Lin, Raymond T. P., Wang, Lin-Fa, Renia, Laurent, Lye, David C., Young, Barnaby Edward

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