Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances by Lim, Hui Kheng, Hughes, Christopher Owen, Lim, Michelle Jing Sin, Li, Jia'En Jasmine, Rakshit, Moumita, Yeo, Calvin, Chng, Kern Rei, Li, Angela, Chan, Joanne Sheot Harn, Ng, Kee Woei, Leavesley, David Ian, Smith, Benjamin Paul Chapman

“…Micronucleus assays typically utilise homogenous in vitro cell lines which poorly recapitulate the physiology, biochemistry and genomic events in the gut, the site of first contact for ingested materials. …”
Get full text

Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

“…By performing anti-cancer compound library screen on isogenic cell lines and using extrachromosomal telomeric C-circles, as a bona fide marker of ALT activity, we identify a receptor tyrosine kinase inhibitor ponatinib that deregulates ALT mechanisms, induces telomeric dysfunction, reduced ALT-associated telomere synthesis, and targets, in vivo, ALT-positive cells. …”
Get full text

NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release by Wang, Qingyun, Wu, Shuquan, Zou, Juan, Liang, Xuyang, Mou, Chengli, Zheng, Pengcheng, Chi, Robin Yonggui

Get full text

Trajectory of immune evasion and cancer progression in hepatocellular carcinoma by Nguyen, Phuong H. D., Wasser, Martin, Tan, Chong Teik, Lim, Chun Jye, Lai, Hannah L. H., Seow, Justine Jia Wen, DasGupta, Ramanuj, Phua, Cheryl Z. J., Ma, Siming, Yang, Jicheng, Sheena D/O Suthen, Tam, Wai Leong, Lim, Tony K. H., Yeong, Joe, Leow, Wei Qiang, Pang, Yin Huei, Soon, Gwyneth, Loh, Tracy Jiezhen, Wan, Wei Keat, Chan, Chung Yip, Cheow, Peng Chung, Toh, Han Chong, Kow, Alfred, Dan, Yock Young, Kam, Juinn Huar, Iyer, Shridhar, Madhavan, Krishnakumar, Chung, Alexander, Bonney, Glenn K., Goh, Brian K. P., Fu, Naiyang, Yu, Victor C., Zhai, Weiwei, Albani, Salvatore, Chow, Pierce K. H., Chew, Valerie

Get full text

A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging by Kovács, Tibor, Szinyákovics, Janka, Billes, Viktor, Murányi, Gábor, Varga, Virginia B., Bjelik, Annamária, Légrádi, Ádám, Szabó, Melinda, Sándor, Sára, Kubinyi, Enikő, Szekeres-Paracky, Cecília, Szocsics, Péter, Lőke, János, Mulder, Jun, Gulyás, Balázs, Renner, Éva, Palkovits, Miklós, Gulya, Károly, Maglóczky, Zsófia, Vellai, Tibor

Get full text

Synergistic-potential engineering enables high-efficiency graphene photodetectors for near- to mid-infrared light by Jiang, Hao, Fu, Jintao, Wei, Jingxuan, Li, Shaojuan, Nie, Changbin, Sun, Feiying, Wu, Steve Qing Yang, Liu, Mingxiu, Dong, Zhaogang, Wei, Xingzhan, Gao, Weibo, Qiu, Cheng-Wei

Get full text

Scalable multifunctional MOFs-textiles via diazonium chemistry by Li, Wulong, Yu, Zhen, Zhang, Yaoxin, Lv, Cun, He, Xiaoxiang, Wang, Shuai, Wang, Zhixun, He, Bing, Yuan, Shixing, Xin, Jiwu, Liu, Yanting, Zhou, Tianzhu, Li, Zhanxiong, Tan, Swee Ching, Wei, Lei

Get full text

Pre-failure strain localization in siliclastic rocks: a comparative study of laboratory and numerical approaches by Bianchi, Patrick, Selvadurai, Paul Antony, Zilio, Dal Luca, Vásquez, Antonio Salazar, Madonna, Claudio, Gerya, Taras, Wiemer, Stefan

“…These simulations revealed three distinct stages of preparatory processes: (i) highly dissipative fronts propagated towards the middle of the sample correlating with the observed acoustic emission locations; (ii) dissipative regions were individuated in the middle of the sample and could be linked to a discernible decrease of the P-wave velocities; (iii) a system of conjugate bands formed, coalesced into a single band that grew from the center towards the sample surface and was interpreted to be representative for the preparation of a weak plane. …”
Get full text

Electrochemical kinetic energy harvesting mediated by ion solvation switching in two-immiscible liquid electrolyte by Lee, Donghoon, Song, You-Yeob, Wu, Angyin, Li, Jia, Yun, Jeonghun, Seo, Dong-Hwa, Lee, Seok Woo

Get full text

Citizenship and the politics of poverty definition during the segregation, apartheid and democratic eras in South Africa: 1910-2010 by Magasela, W

“…The Household Subsistence Level (HSL) and the Minimum Living Level (MLL) were derivatives of the PDL (the HSL was exactly the PDL, the MLL was lower in value) and were conceptually similar were used as poverty definitions and poverty lines to fix the wages of black workers, thus showing the link between the denial of citizenship and the politics of poverty definition.…”

Design an electronic controller for a remote transmission system by Tong, Seng Yip.

“…Communication between the two parts was made possible by an optical link.…”
Get full text

Achieving seamless and scalable ethernet networks using ethernet over SONET by Jape, Milind

“…This dissertation focuses on a new layer 2 mapping technology "Ethernet Over SONET", in which virtual concatenation and link capacity adjustment scheme have given the SONET a new lease of life around the world by extending Ethernet over Metropolitan area Network (MAN) and Wide Area Network (WAN).…”
Get full text

A balanced scorecard approach for wafer fab start-up. by Lye, Irene., Manas Banjan Mati., Yeo, Sock Khim.

“…This study on a Singapore based start-up wafer fab offers an insight on how the BSC measurement and management system approach is being introduced and implemented to link the different business performance drivers and metrics with business vision at a start-up environment.…”
Get full text

Exploratory research on tour packages : comparison of service quality of tour packages by regional and budget airlines by Cai, Jialing, Huang, Junyan, Koh, Pei Jia

“…An exploratory research to establish a link between the SERVQUAL model and the different components of a tour package. …”
Get full text

Structural edge detection of photographic images of rooms with machine learning by Yao, Xin Meng

“…Future works include further enhancing the current model’s accuracy and creating an algorithm to construct a wireframe model from the line equations.…”
Get full text

The design of a CMOS only low-power low-voltage low-dropout voltage regulator (LDO) with an embedded voltage reference by Xie, Xinzhe

“…A recycling folded cascode (RFC) amplifier achieves higher loop gain, improving load and line regulation. A recovery time enhancement circuit reduces overshoot recovery. …”
Get full text

Mimo: multipath signals and location aware by Luo, Yong Bin.

“…In this report, experimental study was conducted to investigate the multipath effect and the improvement to the signal quality by measuring the QoS parameters between MIMO (802.11n) and SISO (802.11a/b/g) under line of sight (LOS) and non-line of sight (NLOS) environment. …”
Get full text

A low-cost dual output switch mode power supply (SMPS) for laptop by Palaniappan Balathandayutham

“…It switches at a much-higher frequency 40 kHz than that of the AC line, which means that the transformer that it feeds can be much smaller than one connected directly to the line/mains. …”
Get full text

Thermodynamics of hairy black holes in Lovelock gravity by Hennigar, Robie A., Tjoa, Erickson, Mann, Robert B.

“…We also report on a number of novel results, including ‘virtual triple points’ and the first example of a ‘λ-line’ — a line of second order phase transitions — in black hole thermodynamics.…”
Get full text
Get full text

Specific inhibition of PI3K p110δ inhibits CSF‐1‐induced macrophage spreading and invasive capacity by Mouchemore, KA, Sampaio, N, Murrey, MW, Stanley, ER, Lannutti, BJ, Pixley, FJ

“…While primary bone marrow‐derived macrophages and the immortalized bone marrow‐derived macrophage cell line M−/−.WT express all three class IA PI3K isoforms, p110δ predominates in the cell line. …”