Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve by DiGregorio, H, Mansoorshahi, S, Carlisle, SG, Tovar Pensa, C, Watts, A, McNeely, C, Sabate-Rotes, A, Yetman, A, Michelena, HI, De Backer, JFA, Mosquera, LM, Bissell, MM, Andreassi, MG, Foffa, I, Hui, DS, Caffarelli, A, Kim, YY, Citro, R, De Marco, M, Tretter, JT, McBride, KL, Body, SC, Milewicz, DM, Prakash, SK

“…This study is aimed to assess the role of rare 22q11.2 CNVs in patients with early-onset BAV (EBAV) and to determine whether these variants are linked to an increased risk of complications. Methods: Whole genome microarray genotyping was conducted on 272 patients with BAV with early onset valve or aortic disease (EBAV) and 272 biological relatives. …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…I apply this assay to investigate a specific mRNA, <em>shot</em>, previously identified as encoding important protein regulators of synaptic development and linked to neurodevelopmental disorders.…”

Antiquity as authority: Jesus and the patriarchs in the Gospel of John by Van Dyk, SL

“…In each instance, the challenge directed to Jesus is contextually linked with his authority to offer eternal life (John 4:10, 13-14; 8:51-52). …”

Understanding health system responsiveness to public feedback at the sub-national level: Insights from Kilifi County, Kenya by Kagwanja, N, Gilson, L, Tsofa, B, Olivier, J, Leli, H, Molyneux, S

“…HFCs are formal structures with community representation linked to a health facility to support community participation in service provision and health outcomes. …”

Edible bird’s nest mitigates histological alterations in the cortexes of rats’ brains subjected to lead toxicity by Albishtue, Abdulla A., Yimer, Nurhusien, Zakaria, MD Zuki A., Haron, Abd Wahid

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Best practices and factors to enhance transfer of training in Oman by Al Ghafri, Ahmed Mohammed Issa

“…The study participants indicated that trainees‟ involvement, setting clear objectives, linking training outcomes to the workplace performance, supervisory support, evaluation assignments, post-training discussions, peers training, having supportive work climate, and performance observation as the best practices that enhance the transfer of training in Oman. …”
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Factors associated with workplace deviant behavior in a public organization in Malaysia and moderating role of religiosity by Radzali, Farah Mardiana

“…Workplace deviant behavior is a multidimensional issue which is linked to wide variety of factors. However, there are limited studies that focus on the predictors of workplace deviant behavior and factors that can reduce workplace deviant behavior. …”
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The Role Perceived Customer Value, Relational Norms, and Switching Costs in Determining Islamic Banking Customes' Loyalty in Dual Banking Environment Settings (S/O 12698) by Abdul Rahman, Maria, Ramli, Mona Fairuz

“…In addition the mediating effects of relationship quality on the links between perceived value, relational norms, and switching costs and customer loyalty, respectively have also been investiagted. …”
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A highly efficient side channel attack with profiling through relevance-learning on physical leakage information by Ali Akbar Pammu, Chong, Kwen-Siong, Wang, Yi, Gwee, Bah-Hwee

“…The converged weights which are being assigned to clustered sampling points are linked to their associated PLI to further increase the correlation of the PLI with the processed data. …”
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Spatio-temporal variations and El Niño modulation of meteorological droughts in Malaysia by Zakaria, Nurul Ain Basirah, Tangang, Fredolin, Salimun, Ester, Amirudin, Abdul Azim, Xiang, Chung Jing, Juneng, Liew, Tan, Mou Leong, Zulkafli, Zed, Marzuki, Marzuki, Santisirisomboon, Jerasorn, Akhir, Mohd Fadzil, Abdullah, Muhamammad Firdaus Ammar, Jamaluddin, Ahmad Fairudz, Mohd, Mohd Syazwan Faisal

“…Drought characteristics exhibit a strong seasonality linked to changes in the Walker circulation and the strengthening and weakening of anticyclonic circulations associated with Rossby waves induced by heating in the Pacific Ocean. …”

Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs by Liu, Xili, Moscvin, Maria, Oh, Seungeun, Chen, Tianzeng, Choi, Wonshik, Evans, Benjamin, Rowell, Sean M., Nadeem, Omar, Mo, Clifton C., Sperling, Adam S., Anderson, Kenneth C., Yaqoob, Zahid, Bianchi, Giada, Sung, Yongjin

“…We show that human MM cell lines (RPMI8226, MM.1S, KMS20, and AMO1) increase dry mass upon bortezomib treatment. …”
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Bursting on a vortex tube with initial axial core-size perturbations by Ji, Lingbo, Van Rees, Wim M.

“…To further assess the relevance and prevalence of bursting in practical settings, subsequent investigations in the stability and sensitivity of our results to varying Reynolds number, nonrectilinear vortex center lines, and external strain fields are needed.…”
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A low-cost, open-source cylindrical Couette rheometer by Erni, Makita, Hart, A. John, Trumper, David, Owens, Crystal E.

“…As a result, rheometers are typically large, expensive, and require additional infrastructure (e.g., gas lines), rendering them inaccessible for regular use by many individuals, small organizations, and educators. …”
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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…METTL8, however, modified only mRNA, as determined by biochemical and genetic analyses in Mettl8 null-mutant mice and two human METTL8 mutant cell lines. Our findings provide the first evidence of the existence of m3C modification in mRNA, and the discovery of METTL8 as an mRNA m3C writer enzyme opens the door to future studies of other m3C epitranscriptomic reader and eraser functions.…”
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Holocene rate of slip and tentative recurrence interval for large earthquakes on the San Andreas fault, Cajon Pass, southern California by Sieh, Kerry, Weldon, Ray J.

“….; it has provided tentative evidence for 6 earthquakes in about the past 1,000 yr. Both lines of evidence suggest an average recurrence interval for large earthquakes of ∼1½ to 2 centuries. …”
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Who learns when workers are trained? a case of safety training of maintenance contractors’ workers for a major petrochemical plant shutdown by A., Fakhru'l-Razi, S.E., Iyuke, M.B., Hassan, M.S., Aini

“…The curves obtained are typical for the whole exercise, which gave perfect straight lines for Introduction to Safety, Hydrogen Sulphide, Confine Space and Permit to Work, respectively. …”
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A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

“…</p> <p>Drug targeting of atrial-specific ion channels has been difficult because of lack of availability of appropriate cardiac cells, and preclinical testing studies have been carried out in non-cardiac cell lines, heterogeneous cardiac populations or animal models that have been unable to accurately represent human cardiomyocyte physiology. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…Steady and unsteady casing static pressure measurements were acquired, using pneumatic lines and high-frequency response (∼100 kHz) Kulite pressure transducers respectively. …”

Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer by McCuaig, S

“…Using a panel of CRC cell lines and primary human organoids, we confirmed that this prognostic association is due to a functional interaction between IL-22 and mutant KRAS by observing that IL-22 enhances chemoresistance, 3-dimensional clonogenicity, and proliferation specifically in CRC cells with both high IL-22 receptor levels and <em>KRAS</em> mutations. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…Applying FlowScore to data from the COMPARE study revealed a positive association with the time-delay from sample collection to measurement, which was verified experimentally. The LifeLines dataset revealed age, sex, and smoking among factors affecting FlowScore. …”