An immunoinformatic approach for identifying and designing conserved multi-epitope vaccines for coronaviruses by Ong, Yu Chuan, Tejo, Bimo Ario, Yap, Wei Boon

“…Methods: This study utilized an immunoinformatic approach to identify evolutionarily conserved CD4+ (HTL) and CD8+ (CTL) T cells, and B-cell epitopes in the coronaviral spike (S) glycoprotein. Results: A total of 132 epitopes were identified, with the majority of them found to be conserved across the bat CoVs, pangolin CoVs, endemic coronaviruses, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV). …”
Get full text

Unraveling the Dynamics of Mental and Visuospatial Workload in Virtual Reality Environments by Bernal, Guillermo, Jung, Hahrin, Yassı, İsmail Emir, Hidalgo, Nelson, Alemu, Yodahe, Barnes-Diana, Tyler, Maes, Pattie

“…Our findings indicate a broadband increase in EEG power just prior to a helper event, followed by a spike of visuospatial engagement (parietal alpha and beta 0-1-3 s) occurring concurrently with a decrease in mental workload (frontal theta 2–4 s), and subsequent decreases in visuospatial engagement (parietal theta at 14 s) and physiological arousal (HRV at 20 s). …”
Get full text

Analysis and reduction of mismatch in silicon neurons by Shuo, Sun, Basu, Arindam

“…The method presented allows the corrected neurons to compute both rate codes and spike time codes in a mismatch resilient fashion…”
Get full text
Get full text

A high efficiency buck converter for IoT sensors by Mo, Mingwei

“…When the system is activated for data collection and processing, the load current may spike to tens of milliamperes. Thus, it's essential for the DC-DC converter to accommodate a broad spectrum of load currents, ensuring versatility and reliability in various operational states. …”
Get full text

Synaptic devices towards neuromorphic electronics by Datta, Indira

“…Area Transfer curves, gate voltage hysteresis loops, and multilevel resistance modulation were studied, and biological functions including long-term potentiation and Depression (LTP and LTD), Excitatory and Inhibitory Postsynaptic Current (EPSC and IPSC), Spike Amplitude and Duration Dependent Plasticity (SADP and SDDP), Paired Pulse Facilitation and Depression (PPF and PPD), and repeated learning and forgetting curves were emulated by our novel device. …”
Get full text

Modeling of functional materials : perovskite solar cells by Aruj Shukla

“…However, for a more holistic analysis of perovskite light harvesters as replacement to the existing TiO2 nano particles, a more nuanced modeling and analysis which incorporates a study of transport properties such as trapping effects (for further spike in efficiency), photo catalytic reaction kinetics and surface & bulk defects (for easier fabrication) is demanded as an integral part of future research plans.…”
Get full text

The impacts of US Fed interest rate liftoff on Southwest Asia stock markets, sovereign bond and currencies by Ooi, Teik Khim

“…Based on the more reliable model I (using FFF), it implies the negative effect of spike in VIX dominated the positive effect from lower market expectation on interest rate lift-off, which led to decline in ASEAN financial market during 2015 A SEAN slump.…”
Get full text

High wavenumber coherent structures in low re apg-boundary-layer transition flow—a numerical study by Lo, Edmond Yat-Man, Chen, Weijia

“…Both parts are imbedded at the primary Λ-vortex stage and spatially coincide with the spike region and high shear layer. The tip part is associated with the later first ring-like vortex, while the rear part with the remainder of the Λ-vortex. …”
Get full text
Get full text

Time to fill up India’s strategic oil reserves by Narula, K

“…Although oil stocks are generally not released to manage oil prices (the IEA’s intention is to stabilize the market and release stocks only in case of physical shortages), it may be possible to use the stored oil to offset a spike in oil prices, especially for developing countries which have administered oil prices.…”

Modelling Malaysia air quality data using Bayesian Structural Time Series models by Aeshah Mohammed, Mohd Aftar Abu Bakar, Mahayaudin M. Mansor, Noratiqah Mohd Ariff

“…The BSTS model integrates three main techniques: The structural model, which employs the Kalman filter approach to model trend and seasonality components; spike and slab regression for variable selection; and Bayesian model averaging to estimate the best-performing prediction model while accounting for uncertainty. …”
Get full text

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St., Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…Here, we investigate thymus-independent DNA origami as an alternative material for multivalent antigen display using the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the primary target of neutralizing antibody responses. …”
Get full text

Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses by Scheim, David E., Parry, Peter I., Rabbolini, David J., Aldous, Colleen, Yagisawa, Morimasa, Clancy, Robert, Borody, Thomas J., Hoy, Wendy E.

“…Consistent with the biochemistry of coronaviruses as well established over decades, SARS-CoV-2 makes its initial attachment to host cells through the binding of its spike protein (SP) to sialylated glycans (containing the monosaccharide sialic acid) on the cell surface. …”
Get full text

NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms by Xue, Jiu Gang, Masuoka, Takayoshi, Gong, Xian Di, Chen, Ken-Shiung, Yanagawa, Yuchio, Law, Alex Sai Kit, Konishi, Shiro

“…Thus NMDARs at glutamatergic synapses on both CA1 pyramidal neurons and interneurons appear to exert feedback and feedforward inhibition for determining the spike timing of the hippocampal microcircuit.…”
Get full text
Get full text

Liquid state machine with dendritically enhanced readout for low-power, neuromorphic VLSI implementations by Roy, Subhrajit, Banerjee, Amitava, Basu, Arindam

“…We show that compared to a single perceptron using analog weights, this architecture for the readout can attain, even by using the same number of binary valued synapses, up to 3.3 times less error for a two-class spike train classification problem and 2.4 times less error for an input rate approximation task. …”
Get full text
Get full text

Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…Chapter 4 expands on T cell responses to VOCs, showing that vaccinated individuals maintain significant T cell reactivity across VOCs despite spike protein mutations that diminish antibody neutralization efficacy. …”

Seroepidemiology of COVID-19 in pregnant women and their infants in Uganda and Malawi across multiple waves 2020-2022 by Hookham, L, Cantrell, L, Cose, S, Freyne, B, Gadama, L, Imede, E, Kawaza, K, Lissauer, S, Musoke, P, Nankabirwa, V, Sekikubo, M, Sommerfelt, H, Voysey, M, PeriCOVID Consortium, Le Doare, K

“…The placental transfer GMR was 1.7, indicating active placental transfer of anti-spike IgG. There was no association between SARS-CoV-2 antibody positivity and adverse pregnancy or infancy outcomes. …”

A hand-targeted auxiliary personal protective equipment for intervention of fomite transmission of viruses by Tan, Justin Kok Soon, Song, Shang Wei, Zeng, Jialiu, Lo, Chih Hung

“…Compared to conventional glove materials, FlexiPalm demonstrated enhanced mechanical durability and breathability, comparable hydrophobicity, and displayed a minimal adsorption of SARS-CoV-2 spike protein and virus-like particles (VLP). Importantly, FlexiPalm was found to bind significantly less viral protein and VLP than artificial human skin, confirming its ability to reduce viral contamination. …”
Get full text

High-performance one-dimensional halide perovskite crossbar memristors and synapses for neuromorphic computing by Vishwanath, Sujaya Kumar, Febriansyah, Benny, Ng, Si En, Das, Tisita, Acharya, Jyotibdha, John, Rohit Abraham, Sharma, Divyam, Dananjaya, Putu Andhita, Jagadeeswararao, Metikoti, Tiwari, Naveen, Kulkarni, Mohit Ramesh Chandra, Lew, Wen Siang, Chakraborty, Sudip, Basu, Arindam, Mathews, Nripan

“…This consequently facilitates the demonstration of accurate handwritten digit recognition from the MNIST database based on spike-timing-dependent plasticity of halide perovskite memristive synapses.…”
Get full text

Berdamai dengan takdir by Nor ‘Asyikin, Mat Hayin

“…Kuala Lumpur: Pakar perubatan pernah menjangkakan hayatnya hanya mampu bertahan sehingga usia 20 tahun susulan penyakit atrofi otot spina (SMA) jenis dua dihidapi.…”
Get full text

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

“…We also present an accurate quantitation of serological responses for SARS-CoV-2 that exploits a unique set of in-house, recombinant human monoclonal antibodies targeting the viral Spike and nucleocapsid proteins and demonstrate a reduction in neutralizing antibody titres across all groups 6 months post-vaccination. …”
Get full text