Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms by Sun, Yang, Chung, Hwa Hwa, Woo, Amanda Rui En, Lin, Valerie C.-L.

“…In conclusion, PRMT6 requires its methyltransferase activity to enhance ERα's ligand-induced activity, but its effect on ligand-independent activity is likely mediated through competing with Hsp90 for binding to the C-terminal domain of ERα. …”
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Fluid fluxing and accumulation drive decadal and short-lived explosive basaltic andesite eruptions preceded by limited volcanic unrest by Utami, Sri Budhi, Costa, Fidel, Lesage, Ph., Allard, P., Humaida, H.

“…The textures and compositional zoning of orthopyroxene and plagioclase do not support intrusion of more primitive magma as the driver for the eruption, and we instead propose that pre-eruptive fluid accumulation and hightemperature fluid fluxing from depth (likely dominated by CO2) played a major role in priming the eruption to occur. …”
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Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics by Wilde, Joshua T., Springs, Stacy, Wolfrum, Jacqueline M., Levi, Retsef

“…Additionally, HMMScan indicates the particular lots most likely to be related to risky states of the manufacturing or supply chain condition. …”
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Insights from an Experiment Crowdsourcing Data from Thousands of US Amazon Users: The importance of transparency, money, and data use by Berke, Alex, Mahari, Robert, Pentland, Sandy, Larson, Kent, Calacci, Dana

“…Age, race, education, and gender also played a role, where female and less-educated participants were more likely to share. Our study design enables a unique empirical evaluation of the “privacy paradox”, where users claim to value their privacy more than they do in practice. …”
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Facilitating gamified lower-extremity rehabilitation through novel VR MI-BCI system by Pramotedham, Chavalit

“…Additionally, while the difference in BCI performance in VR vs. 2D was not deemed to be statistically significant (p = 0.38), this is likely due to the extremely small sample size (n = 12) within this preliminary study. …”
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3D confined jet scour at a wall by Chee, Wei Hong

“…Beyond the jet outlet location, the scoured sediment bed was observed to be uneven likely due to the recirculating flow affected by the ridges formed. …”
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Island area and remoteness shape plant and soil bacterial diversity through land use and biological invasion by Xu, Mingshan, Yang, Anna, Yang, Xiaodong, Cao, Wenting, Zhang, Zengke, Li, Zengyan, Zhang, Yu, Zhang, Huaguo, You, Wenhui, Yan, En-Rong, Wardle, David A.

“…Soil bacterial diversity was directly negatively impacted by island remoteness, and indirectly negatively impacted by island remoteness through increased soil electrical conductivity likely caused by greater salinity from sea spray. …”
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Sustainable structural design optimization - prestressed concrete beams by Ng, Kok Hang

“…The case study revealed that for an 18 m wide bridge, a 3-beam layout generates lesser overall EC than a 4-beam layout and a beam length (thus column spacing) of 20 to 26 m is likely to produce the lowest EC for the bridge system. …”
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Three essays on corporate finance by Sun, Rui

“…Special features of private firms – more concentrated equity ownership, more powerful shareholders with a strong desire for liquidity and diversification, and higher agency costs associated with debt finance are very likely to play a vital role in shaping their cash flow allocation. …”
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Rapid and punctuated Late Holocene recession of Siling Co, central Tibet by Shi, Xuhua, Kirby, Eric, Furlong, Kevin P., Meng, Kai, Robinson, Ruth, Lu, Haijian, Wang, Erchie

“…Mapping and surveying of lacustrine shorelines coupled with optically stimulated luminescence dating of associated deposits indicate protracted occupation of a highstand elevation from >8 ka to 4 ka, followed by rapid recession that was likely punctuated by several stillstands of centennial-scale duration. …”
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Morphology control and thermal stability of binderless-graphene aerogels from graphite for energy storage applications by Nguyen, Son Truong, Nguyen, Hoa Tien, Rinaldi, Ali, Nguyen, Nam P. V., Fan, Zeng, Duong, Hai Minh

“…Of all the challenges facing human beings in the near future, energy related issues are likely to be the grandest. To achieve a more sustainable society with adequate renewable energy and less environmental pollution, more versatile, robust and efficient approaches in electric energy storage and conversion are needed. …”
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A comparison of sodium-glucose co-transporter 2 inhibitor kidney outcome trial participants with a real-world chronic kidney disease primary care population by Forbes, AK, Hinton, W, Feher, MD, Elson, W, Ordóñez-Mena, JM, Joy, M, Fan, X, Banerjee, D, Cole, NI, Munro, N, Whyte, M, Suckling, RJ, Swift, PA, de Lusignan, S

“…Females were under-represented and less likely to be eligible for the trials.</p> <br> <p><strong>Conclusion:</strong> SGLT2 inhibitor kidney outcome trials represent a subgroup of people with CKD at high risk of adverse kidney events. …”

Environmental risk factors for self-harm during imprisonment: a prospective cohort study by Stephenson, T, Harris, I, Armstrong, C, Fazel, S, Short, R, Blackwood, N

“…Findings regarding staff-prisoner ratio and self-harm most likely reflect a reverse causal relationship. Replication in larger cohort studies is required to address the limitations of this pilot study.…”

The impact of social isolation on delayed hospital discharges of older hip fracture patients and associated costs by Landeiro, F, Leal, J, Gray, A

“…Patients who were admitted from an institution were less likely to have delayed discharges (OR 0.2) with 5.5 fewer days of delay. …”

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…Discordance between genetic and primary care data was also observed, e.g., abdominal aortic aneurysm and bladder cancer co-occurred in primary care but were not genetically correlated (Odds-Ratio = 2.23 [2.09:2.37], 𝑅𝑔 = 0.04 [−0.20:0.28]) and schizophrenia and fibromyalgia were less likely to co-occur together in primary care but were positively genetically correlated (OR = 0.84 [0.75:0.94], 𝑅𝑔 = 0.20 [0.11:0.29]).…”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Assessment of novel pre-erythrocytic malaria vaccines in humans by Venkatraman, N

“…In addition to humoral immunity, it is widely recognised that T-cell mechanisms are likely to play an important role in malaria immunity and heterologous prime-boost regimes using viral-vectored vaccines have been shown to induce potent T-cell responses. …”

Multi-species rotational grazing of small ruminants regenerates undergrowth vegetation while controlling weeds in the oil palm silvopastoral system by Tohiran, Kamil Azmi, Nobilly, Frisco, Zulkifli, Raja, Yahya, Muhammad Syafiq, Norhisham, Ahmad Razi, Rasyidi, Md Zainal, Azhar, Badrul

“…The use of single-species livestock grazing is likely to cause oil palm growers to use herbicides to control undesirable weeds. …”
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The level of knowledge, attitude and practice towards Covid-19 immunisation among medical students in public medical schools in Malaysia by Mohamad Zainal, Nurul Hayati, Mohammed Ayyub, Safiyya, Yi, Chang Fang, Zaman, Arif Najmi Shahrir, Mohd Nor, Nurul Huda, Omar, Norsuhana, Ku Mohd Noor, Ku Mastura, Hamimi Wahid, Hanan

“…Respondents in the age group of 21 to 24 years old (p < 0.001) and 25 to 29 years old (p = 0.016), and Indian ethnicity (p = 0.006) were more likely to have good knowledge. Respondents registered in Malaysia’s National COVID-19 vaccination program were considered as having a positive attitude (n = 264, 61.8). …”
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Rotor angle stability-constrained dispatch and control of large-scale wind penetrated power system by Yuan, Heling

“…In general, four main effects on power system transient stability are: 1) wind generation has no contribution to system inertia and system with synchronous generators replaced by wind turbines will lead to reduction of inertia, 2) power electronics converter-based interfacing is added when wind turbines are implemented, which will change the dynamic behavior of the system, 3) power dispatch of synchronous machines will change fast to compensate wind power variation, 4) the magnitude and direction of power flows will fluctuate quickly and randomly in the transmission lines. Hence, it is an essential and significant problem to maintain system’s stability with high level wind power penetration. …”
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