RNA interference silencing of interleukin-6 in mesenchymal stromal cells and antitumour efficacy against multiple myeloma cells by Teoh, Hoon Koon

“…In conclusion, both RNAi pathways were equally effective in suppressing IL-6 expression in MSC and displayed in vitro and in vivo antitumor efficacy against U266 cells. These findings support the feasibility of using RNAi as an alternative approach for targeted suppression of IL-6 in MSC to inhibit multiple myeloma cell growth.…”
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Savings and Investment Behaviour of the Consumer of Financial Services and Their Service Expectations from Banks (S/O 12349) by Ahmad, Nor Hayati, Saha, Asish, Eam, Lim Hock, Katib, Mohamed Nasser, Musa, Muhammad Muhaizam, Yeok, Siew Goh

“…Another significant findings based on logit model to estimate the predicted probability of the relative quality of customer service shows CIMB customers are less satisfied with the location, employee responsiveness, and administrative effectiveness. …”
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Behind the Two-Wheeled Vehicle: Understanding Riders' Behaviour in School Zones (S/O: 13058) by Abdul Hanan, Suhaila, Zainuddin, Nizamuddin, King, Mark, Lewis, Ioni

“…This most probably because school zones are congested with traffic, thus, the motorcyclists may ride safely and comply with the SZSL regardless the other things. Overall, the findings provide support for the application of the TPB to understand motorcyclists intention and behaviour in school zones. …”
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Developing a Household Flood Vulnerability Index for Managing the Risk of Flood Disasters (S/O 13584) by Hassan, Sallahuddin, Abu Bakar, Arpah, Othman, Zalila, Khalid, Mohamad Sukeri, Abu Talib, Mansor

“…While floods cannot be fully prevented despite recent developments in infrastructures, preparedness, recovery and response, enhancing community resilience is therefore needed to be a priority in flood-prone communities. The findings of this study tend to vary by the district and state, accordingly. …”
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基于经验模态分解和神经网络的微网混合储能容量优化配置 = Capacity optimization of hybrid energy storage systems in microgrid using empirical mode decomposition and neural network... by 孙承晨 Sun Chengchen, 袁越 Yuan Yue, Choi, San Shing, 李梦婷 Li Mengting, 张新松 Zhang Xinsong, 曹阳 Cao Yang

“…A neural network model is utilized to determine the capacity of the HESS through finding a compromise between the cost of the system and the LOS of the power. …”
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Colon Cancer Disparities in Stage at Presentation and Time to Surgery for Asian Americans, Native Hawaiians, and Pacific Islanders: A Study with Disaggregated Ethnic Groups by Jain, Bhav, Bajaj, Simar S., Patel, Tej A., Vapiwala, Neha, Lam, Miranda B., Mahal, Brandon A., Muralidhar, Vinayak, Amen, Troy B., Nguyen, Paul L., Sanford, Nina N., Dee, Edward C.

“…Conclusions Our findings reveal key disparities in stage at presentation and time to surgery by race/ethnicity among AANHPI subgroups. …”
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Mechanistic Studies of Interfacial Proton-Coupled Electron Transfer to Molecularly Defined Surface Sites by Lewis, Noah B.

“…With these observations we construct a mechanistic model in which I-PCET is not a single step, but a multi-step reaction sequence in which elementary I-PCET is gated by an ion exchange reaction between proton donor/acceptor species and proton-neutral supporting electrolyte at the electrode-electrolyte interface. These findings demonstrate how supporting electrolyte can be leveraged as a design parameter to independently control electrolyte pH and the rates of I-PCET-based reactions.…”
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GPU-Oriented Algorithms for Continuous Energy Monte Carlo Neutron Transport by Ridley, Gavin

“…We then present a specialized root-finding algorithm that takes advantage of the structure of the problem to efficiently sample the resonance upscatter effect on GPUs. …”
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Sociospatial reframing of walking through inclusive streets and urban heritage by Wang, Yongcheng

“…Underscored by qualitative and quantitative findings, this thesis could potentially provide urban planner and policy makers with an interdisciplinary framework of inclusive streets and urban heritage, and the integration of the two, to foster pedestrian-oriented planning practices that are responsive to community needs and sensitive to local contexts. …”
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发达地区失地老人养老支持体系内卷化及其突破 — 基于苏州市的个案研究 = The involution of the eldercare system for the landless elderly in China’s developed regions : a case study based on Suzhou municipality... by 叶继红 Ye Jihong, 占少华 Zhan Shaohua

“…This article, based on an analysis of a “rural to residential”community in Suzhou Municipality, Jiangsu Province, finds that land acquisition has generated a strong impact on the life and pension style of the landless elderly. …”
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Analysis of lava flow impacts for use in risk assessments by Meredith, Elinor Siwan

“…Along with the 2018 Kīlauea assessment, I used this compiled dataset to assess relationships between lava flow thickness as a proxy for hazard intensity and damage severity, presenting the first empirically-derived and non-linear fragility functions for lava flow structure damage, for different structure types. The findings show a recent increase in recorded impact events, and that these events occur more frequently than previously thought, with almost three impact events, to population centres, per decade in the past 100 years. …”
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Mechanics in dehydration-induced leaf morphing behaviors by Guo, Kexin

“…This thesis focuses on three shape-morphing phenomena observed in plant leaves as passive responses to the strain mismatch caused by dehydration. The research findings indicate the significant influence of mechanics on the formation of leaf shapes. …”
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Efficacy of Wolbachia-mediated sterility to reduce the incidence of dengue: a synthetic control study in Singapore by Lim, Jue Tao, Bansal, Somya, Chong, Chee Seng, Dickens, Borame, Ng, Youming, Deng, Lu, Lee, Caleb, Tan, Li Yun, Chain, Grace, Ma, Pei, Sim, Shuzhen, Tan, Cheong Huat, Cook, Alex R., Ng, Lee Ching

“…To compare interventions, we used the synthetic control method to generate appropriate counterfactuals for the intervention towns using a weighted combination of 30 control towns between EW 1, 2014 and EW 26, 2022. Findings: Our study comprised an at-risk population of 607 872 individuals living in intervention sites and 3 894 544 individuals living in control sites. …”
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Origin of a topotactic reduction effect for superconductivity in infinite-layer nickelates by Zeng, Shengwei, Tang, Chi Sin, Luo, Zhaoyang, Chow, Lin Er, Lim, Zhi Shiuh, Prakash, Saurav, Yang, Ping, Diao, Caozheng, Yu, Xiaojiang, Xing, Zhenxiang, Ji, Rong, Yin, Xinmao, Li, Changjian, Wang, Renshaw Xiao, He, Qian, Breese, Mark B. H., Ariando, A., Liu, Huajun

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Dynamics of current-driven magnetic domain walls and skyrmions by Indra Purnama

“…At present, the investigation of domain wall dynamics is mainly focused on finding additional driving mechanisms to improve its mobility. …”
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The development and application of fish scale waste for tissue engineering applications : waste-to-resource conversion of resource resilient materials by Wang, Jun Kit

“…Therefore in this thesis, fish scale-derived collagen (FSCol) and fish scale-derived HA (FSHA) were extracted from different fish species and the potential of the extracted products for various TE applications were explored. Findings from the studies demonstrated that Type I FSCol was successfully extracted using a modified acid solubilization extraction method with preserved structural quality (i.e. retention of triple helical structures) where snakehead scale-derived collagen (SHCol) exhibited significant higher (p < 0.05) thermal stability as compared to other species. …”
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Biomolecular hydration in protein-protein interaction, protein stability and aggregation and lead optimization : computational studies by Mohan Rajan Pradhan

“…Combining systematic data mining and quantification of these hydration sites using „JAL‟ a novel two water-bridge motif is identified that appears to be central to the nucleotide recognition by eIF4E. This is a novel finding and I believe will facilitate the design of specific inhibitors of eIF4E which is a therapeutic target in oncology. …”
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New algorithms for hardware-efficient implementation of sign detection and magnitude comparison in residue number systems by Sachin Kumar

“…Specifically, the following new findings and results are reported in this thesis. …”
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Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

“…Chapter seven also discussed the implications of the findings described, with an emphasis on the potential future avenues of research within the field of neurogenic hypertension.…”

Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Feigin, VL, Abate, MD, Abate, YH, Bandyopadhyay, S, Bennett, DA, Lacey, B, Newton, CRJ

“…We also calculated burden of stroke attributable to 23 risk factors and six risk clusters (air pollution, tobacco smoking, behavioural, dietary, environmental, and metabolic risks) at the global and regional levels (21 GBD regions and Socio-demographic Index [SDI] quintiles), using the standard GBD methodology. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. <p><b>Findings</b></p> In 2021, stroke was the third most common GBD level 3 cause of death (7·3 million [95% UI 6·6–7·8] deaths; 10·7% [9·8–11·3] of all deaths) after ischaemic heart disease and COVID-19, and the fourth most common cause of DALYs (160·5 million [147·8–171·6] DALYs; 5·6% [5·0–6·1] of all DALYs). …”