Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro by Smarslik, Maren, Inal, Jameel

“…In this study, the cytotoxic effects of 5-FU and iCRT3 were investigated using the Caco-2 colon adenocarcinoma cell line, marking the first investigation of their combined effects. …”
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Content learning in Japanese and English medium instruction: comparing chemistry learning outcomes in Japanese higher education by Aizawa, I

“…<p>English Medium Instruction (EMI) is rapidly gaining momentum in line with internationalisation of higher education trends. …”

An analysis of contact stiffness and frictional receding contacts by Parel, KS

“…Then, a fundamental 2D frictional receding contact problem involving a homogeneous linear elastic infinite layer pressed by a line load onto a half-plane of the same material was analysed. …”

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. However, if a short course of biologics can rapidly suppress inflammation allowing treatment to be withdrawn and response maintained on methotrexate, this may be a cost-effective model for early use.…”

Implementing strategies to improve uptake of patient-reported outcome measures (PROMs) in gender-affirming care: a mixed-methods implementation study by Kamran, R, Jackman, L, Goodwin, C, Laws, A, Stepney, M, Harrison, C, Jain, A, Rodrigues, J

“…</p> <p><strong>Main outcome(s) and measure(s)</strong> Response rates were calculated at 2-week intervals, in line with the deployment of each implementation strategy. …”

Ultra-thin oxide films by Hu, X

“…Various sizes have been found, and sides of these equilateral triangles all show a double-line feature aligned along the 〈 1 ^ˉ<sub style="position: relative; left: -.4em;">1</sub> 0〉 directions of the Au(111) lattice. …”

Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…The aim of this study was to evaluate the in vitro activities of ethanolic extract of Tinospora crispa (EETC) on protein kinases involved in the lytic cycle of T. gondii infection in Vero cell line. The EETC was obtained through the maceration of dried stem powder. …”
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Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…Therefore, this study focuses on metabolite profiling, in silico or pharmacoinformatic activity and mechanisms, as well as advanced validation on in vitro cell lines. Ten compounds identified in E. bulbosa bulb ethanolic extract (EBE) showed cancer receptor and radical inhibitory activity via network pharmacology and molecular docking simulation. …”
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Attitudinal Factors of Fishermen Trapped in the B40 Category: an Empirical Study by Mustafar, Mastora, Mat Yamin, Fadhilah, Mohamed Ismail, Risyawati, Mohd Nawi, Nur Syazwani, Abu Bakar, Siti Zakiah, Johari, Ayub

“…However, its importance is not in line with the well-being of key players in the fishing industry itself, especially Zone A fishermen who are mostly in the Bottom 40% (B40) of household income category. …”
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Two-step machine learning enables optimized nanoparticle synthesis by Mekki-Berrada, Flore, Ren, Zekun, Huang, Tan, Wong, Wai Kuan, Zheng, Fang, Xie, Jiaxun, Tian, Isaac Parker Siyu, Jayavelu, Senthilnath, Mahfoud, Zackaria, Bash, Daniil, Hippalgaonkar, Kedar, Khan, Saif, Buonassisi, Tonio, Li, Qianxiao, Wang, Xiaonan

“…While remaining interpretable by humans, the proposed framework efficiently optimizes the nanomaterial synthesis and can extract fundamental knowledge of the relationship between chemical composition and optical properties, such as the role of each reactant on the shape and amplitude of the absorbance spectrum.…”
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VolcAshDB: a volcanic ash database of classified particle images and features by Benet, Damià, Costa, Fidel, Widiwijayanti, Christina, Pallister, John, Pedreros, Gabriela, Allard, Patrick, Humaida, Hanik, Aoki, Yosuke, Maeno, Fukashi

“…For each particle image, we quantitatively extracted 33 features of shape, texture, and color, and petrographically classified each particle into one of the four main categories: free crystal, altered material, lithic, and juvenile. …”
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Fluid-fluid displacement in porous-media microfluidics by Qiu, Yu

“…We then experimentally study the shape of a moving interface in a capillary tube prewetted with the invading liquid. …”
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Additive manufacturing of alloys with programmable microstructure and properties by Gao, Shubo, Li, Zhi, Van Petegem, Steven, Ge, Junyu, Goel, Sneha, Vas, Joseph Vimal, Luzin, Vladimir, Hu, Zhiheng, Seet, Hang Li, Sanchez, Dario Ferreira, Van Swygenhoven, Helena, Gao, Huajian, Seita, Matteo

“…However, this practice is inapplicable to near-net-shape metal parts produced by additive manufacturing (AM), since it would irremediably compromise their carefully designed geometries. …”
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Enhanced flotation of high density polyethylene and polyvinyl chloride mixtures based on clean corona modification by Wang, Yinan, Zhao, Yue, Guo, Linyi, Han, Fengrong, Li, Xiaofeng

“…Since the corona modification is reagent-free-addition and rapid in-line process, this work showed great advantages in the total cost of separation (only 450.03 USD/t) and potential environmental benefits, which also paves a clean way for the recycling of HDPE and PVC.…”
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The influence of molasses concentration on the physical and mechanical properties of evaporation boat waste-based crucibles by Rusiyanto, Rusiyanto, Widodo, Rahmat Doni, Prasetyo, Ares Yudi, Fitriyana, Deni Fajar, Bahatmaka, Aldias, Sudiyono, Sudiyono, Setiadi, Rizki, Rengga, Wara Dyah Pita, Ismail, Rifky, Bayuseno, Athanasius Priharyoto, Priyatmojo, Anjar, Ramdhani, Wahyu, Arifiadi, Ferry, Ansori, Chusni, Irawan, Agustinus Purna, Cionita, Tezara, Siregar, Januar Parlaungan

“…The use of evaporation vessel waste and molasses in the production of crucibles in this study is in line with Sustainable Development Goals (SDGs) 3, 7, 14, and 15, which relate to improving excellent health and well-being, ensuring access to affordable energy, and conserving marine and terrestrial ecosystems.…”
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Positive innovative thinking based on the integration of spiritual knowledge through the subjects of design and technology by Zaipah, Ismail, Aede Hatib, Musta’amal @ Jamal, Nornazira, Suhairom, Rohana, Hamzah

“…However, the teaching and learning process and the existing curriculum often ignore the spiritual element, which can play an important role in forming positive innovative thinking and student morals. This research is in line with the Sustainable Development Goals (SDG), especially SDG 4 (Quality Education) and SDG 9 (Industry, Innovation, and Infrastructure), by emphasizing the integration of intellectual and spiritual knowledge education to produce students with positive innovative thinking and noble character. …”
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Mental-LLM: Leveraging Large Language Models for Mental Health Prediction via Online Text Data by Xu, Xuhai, Yao, Bingsheng, Dong, Yuanzhe, Gabriel, Saadia, Yu, Hong, Hendler, James, Ghassemi, Marzyeh, Dey, Anind K., Wang, Dakuo

“…We highlight the important ethical risks accompanying this line of research.…”
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Intermittent actuation attenuates fibrotic behaviour of myofibroblasts by Ward, Niamh A., Hanley, Shirley, Tarpey, Ruth, Schreiber, Lucien H.J., O'Dwyer, Joanne, Roche, Ellen T., Duffy, Garry P., Dolan, Eimear B.

“…Here, we use analytical, computational, and in vitro models to understand the response of human myofibroblasts (WPMY-1 stromal cell line) to intermittent actuation using soft robotics and investigate how actuation can alter the secretion of collagen and pro/anti-inflammatory cytokines by these cells. …”
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Device and material investigations of GaN enhancement-mode transistors for Venus and harsh environments by Xie, Qingyun, Niroula, John, Rajput, Nitul S., Yuan, Mengyang, Luo, Shisong, Fu, Kai, Isamotu, Mohamed Fadil, Palash, Rafid Hassan, Sikder, Bejoy, Eisner, Savannah R., Surdi, Harshad, Belanger, Aidan J., Darmawi-Iskandar, Patrick K., Aksamija, Zlatan, Nemanich, Robert J., Goodnick, Stephen M., Senesky, Debbie G., Hunter, Gary W., Chowdhury, Nadim, Zhao, Yuji, Palacios, Tomás

“…Through transistor, Transmission Line Method (TLM), and Hall-effect measurements vs temperature, it is revealed that the mobility decrease is the primary cause of reduction of on-state performance of this GaN transistor at high temperature. …”
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Using shock tube species time-histories in Bayesian parameter estimation: Effective independent-data number and target selection by Chen, Huaibo, Ji, Weiqi, Cassady, Séan J, Ferris, Alison M, Hanson, Ronald K, Deng, Sili

“…This further implies that several critical points can represent the entire line for point estimation. This paper can provide a reference both for modelers about reasonable utilization of species time-histories, and for experimentalists about the importance of a detailed probability distribution of measurement error, as well as experiment design with emphasis on critical points.…”
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