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    LL5 directs the translocation of Filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2 by Takabayashi, Tetsuji, Xie, Min-Jue, Takeuchi, Seiji, Kawasaki, Motomi, Yagi, Hideshi, Okamoto, Masayuki, Rahman, Mohammad Tariqur, Malik, Fawzia, Kuroda, Kazuki, Kubota, Chikara, Fujieda, Shigeharu, Nagano, Takashi, Sato, Makoto

    Published 2010
    “…Because F-actin initially polymerizes near the plasma membrane, it is likely that membrane-recruited Filamin A efficiently cross-links newly polymerized F-actin, leading to enhanced lamellipodium formation at the site of PtdIns(3,4,5)P3 accumulation. Moreover, we demonstrate that co-recruited SHIP2 dephosphorylates PtdIns(3,4,5)P3 at the same location. …”
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