The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

“…Osteoporosis is caused by an imbalance in bone resorption and formation due to either molecular mutations, oestrogen reduction at menopause, oxida-tive stress, as well as life style, leading to a characteristic low bone density and/or thin-ning that predisposes patients to skeletal fracture and breakage upon minimal physical trauma. …”

Social network structure in autistic individuals: a systematic review by Lei, J, Qian, X, Kim, KM

“…Other social network mapping tools in adults captured both social network structure (e.g., number of network members and their connections with each other), and some captured support provided by network members, with family members often cited as providing the most frequent and best quality support across a range of life domains.</p> <p><b>Conclusion:</b> There is limited knowledge about social network structure for autistic individuals beyond childhood in classroom settings. …”

Preterm birth and cardiometabolic health trajectories from birth to adulthood: the Avon Longitudinal Study of Parents and Children by Clayton, GL, Howe, LD, O’Keeffe, LM, Lewandowski, A, Lawlor, DA, Fraser, A

“…<p><strong>Background:</strong> Adults who were born prematurely (&lt;37 weeks gestation) are at increased cardiovascular disease risk, but it is unclear when in the life course this risk emerges. Our aim was to compare trajectories of multiple cardiometabolic risk factors from childhood to early adulthood between those who had and had not been born preterm.…”

Characterising the metabolic functionality of the preterm neonatal gut microbiome prior to the onset of necrotising enterocolitis: a pilot study by Chapman, JA, Wroot, E, Brown, T, Beck, LC, Embleton, ND, Berrington, JE, Stewart, CJ

“…Results: Eight NEC infants were selected of median gestation 26.5 weeks and median day of life (DOL) of NEC onset 20, with one sample used per infant, collected within one to eight days (median four) before NEC onset. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…Shroudless turbines experience high heat loads on the rotor tip and casing, which makes them one of the life-limiting components for an engine. If the rotor tip starts to erode, then the tip clearance increases which increases the over-tip leakage flow, resulting in reduced stage efficiency and ultimately, the engine lifetime. …”

Technology integration in newborn care: examining communication and decision-making among health professionals in Kenyan hospitals by Ngaiza, GK

“…These factors directly affect the use of life-saving technologies. A tailored approach that considers these variables, rather than a one-size-fits-all approach, will ensure better integration and sustainability of these technologies, leading to improved outcomes in newborn care.…”

'The listening series': increasing equity, diversity and inclusion in patient and public involvement and engagement for policy research by listening to and learning from under-repr... by Bevan, C, Alderdice, F, Darby, S, Gilzean-Hughes, S, McLeish, J, Mulla, S, Plachcinski, R, Wilkinson, S, Williams, H, Rowe, R

“…<p><strong> Learning and reflection</strong></p> Five key themes were identified: ‘build trust’; ‘involve us from the beginning’; ‘show us impact’; ‘use clear, appropriate and inclusive communication’; and ‘imagine life in our shoes’. We used the learning to create a guidance document for researchers and an accompanying 15-minute film. …”

Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in... by Khan, I, Taylor, SJC, Robinson, C, Moschopoulou, E, McCrone, P, Bourke, L, Thaha, M, Bhui, K, Rosario, D, Ridge, D, Donovan, S, Korszun, A, Little, P, Morgan, A, Quentin, O, Roylance, R, White, P, Chalder, T

“…: Background: Two million people in the UK are living with or beyond cancer and a third of them report poor quality of life (QoL) due to problems such as fatigue, fear of cancer recurrence, and concerns about returning to work. …”

Evaluating the cost-effectiveness of antenatal screening for major structural anomalies during the first trimester of pregnancy: a decision model by Campbell, H, Karim, J, Papageorgiou, AT, Wilson, E, Rivero-Arias, O

“…</p> <br> <p><strong>Main outcomes measures:</strong> Expected numbers of pregnancy outcomes, healthcare costs, and maternal quality adjusted life years (QALYs). Estimation of the incremental costeffectiveness ratio (ICER), likelihood of cost-effectiveness, and a value of information (VoI) analysis assessing if further research is needed before making a decision about screening.…”

Citizenship and the politics of poverty definition during the segregation, apartheid and democratic eras in South Africa: 1910-2010 by Magasela, W

“…</p> <p>In the post-apartheid era with a Constitution that enshrines a Bill of Rights with explicit and specific social and economic rights, and human dignity, social justice and the commitment to improve the quality of life of all citizens as foundational values aimed at addressing extensive multi-dimensional poverty, apartheid era concepts and definitions of poverty (mainly the HSL and MLL) continue. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…Applying FlowScore to data from the COMPARE study revealed a positive association with the time-delay from sample collection to measurement, which was verified experimentally. The LifeLines dataset revealed age, sex, and smoking among factors affecting FlowScore. …”

Gender differences in perceptions of psoriatic arthritis disease impact, management, and physician interactions: results from a global patient survey by Eder, L, Richette, P, Coates, LC, Azevedo, VF, Cappelleri, JC, Johnson, EP, Hoang, M, Moser, J, Kessouri, M

“…<p><strong>Introduction:</strong> We evaluated the impact of gender on disease severity, health-related quality of life (HRQoL), treatment management, and patient–healthcare professional (HCP) interactions from the perspectives of patients with psoriatic arthritis (PsA).…”

A study of human monoclonal antibodies to influenza and ebola viruses by Rijal, P

“…</p> <p>A second consequence of preferential selection of B cell responses from memory cells laid down early in life, is the expansion of broadly cross-reactive clones during exposures to viruses that are only distantly related to the original stimulus. …”

Climate worry: associations with functional impairment, pro-environmental behaviors and perceived need for support by Lenhard, F, Fernández de la Cruz, L, Wahlund, T, Andersson, E, Åhlén, J, Fuso Nerini, F, Akay, H, Mataix-Cols, D

“…Background: A large proportion of individuals experience functional impairment in everyday life due to climate worry. However, the current understanding of this functional impairment is limited by the use of suboptimal measures. …”

Dress, Feminism, and British New Woman Novels by Allen-Johnstone, C

“…</em> (1926, posthumously), Sarah Grand's <em>Ideala: A Study from Life</em> (1881) and <em>The Heavenly Twins</em> (1893), and Grant Allen's <em>The Woman Who Did</em> (1895) and <em>The Type-Writer Girl</em> (1897). …”

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in... by Png, ME, Harris, V, Grabey, J, Hart, ND, Jani, BD, Butler, D, Carson-Stevens, A, Coates, M, Cureton, L, Dobson, M, Dorward, J, Evans, P, Francis, N, Gbinigie, OA, Hayward, G, Holmes, J, Hood, K, Khoo, S, Ahmed, H, Lown, M, McKenna, M, Mort, S, Nguyen-Van-Tam, J, Rahman, N, Richards, DB, Thomas, N, van Hecke, O, Hobbs, FR, Little, P, Yu, L-M, Butler, CC, Petrou, S

“…Cost-effectiveness was expressed in terms of incremental cost per quality-adjusted life year (QALY) gained. Sensitivity and subgroup analyses assessed the impacts of uncertainty and heterogeneity. …”

Using QALYs as an outcome for assessing global prediction accuracy in diabetes simulation models by Dakin, H, Gao, N, Leal, J, Holman, RR, Tran-Duy, A, Clarke, P

“…<p><strong>Objectives:</strong> (1) To demonstrate the use of quality-adjusted life-years (QALYs) as an outcome&nbsp;measure for comparing performance between simulation models and identifying the most&nbsp;accurate model for economic evaluation and health technology assessment. …”

Effect on growth performance and nutritive value of cultivated azolla filiculoides as an alternative feedstuff for ruminant by Hamidan, Mohammad Fitri Rimi, Mohd Nadzir, Mohd Noor Hisham, Shohaimi, Shamarina, Bidin, Habsah, Samat, Noraini

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Newborn screening for severe combined immunodeficiency in Malaysia: current status, challenges and progress by Chang, Wai Leng, Mohd Noh, Lokman, Abdul Latiff, Amir Hamzah, Woo, Kent Chee Keen, Ismail, Intan Hakimah, Abd Hamid, Intan Juliana, Siniah, Sangeetha, Zainal Abidin, Mohd Azri, Sham, Marina, Mat Ripen, Adiratna, Baharin, Mohd Farid, Abdul Wahab, Asrul, Zainudeen, Zarina Thasneem, Hashim, Ilie Fadzilah, Wong, Yee Ming, Ahmad Shawaludin, Mohamad Qazreen, Ali, Adli

“…Introduction: Early diagnosis of Severe Combined Immunodeficiency (SCID) increases survival outcomes and quality of life while significantly minimizing healthcare burden and costs. …”
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Unveiling potential therapeutic targets for breast cancer recurrence: differentially expressed genes and pathways in post-surgery patients by Hamad, Hamad Ali, Saeed, Hammad Khalaf, Hussein, Talib Hammad, Hussain, Abdalwahab Bdewi, Md Hashim, Nur Fariesha

“…The findings have uncovered key therapeutic targets associated with tumor recurrence through potential ECM-related genes whose overexpression may significantly contribute to tumorigenesis in breast cancer survivors by epithelial-to-mesenchymal transition and targeting them may improve the chances of better survival breast cancer patients and increase the quality of life by reducing the chances of recurrence. However, the study is solely bioinformatics-based; therefore, future study will be experimental validations to bring forth these key genes as potential therapeutic targets.…”
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