Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…However, BCAS-induced changes in hippocampal gene expression differed between young and aged mice. Specifically, transcriptomic analysis indicated that in comparison to young sham mice, many pathways altered by BCAS in young mice resembled those already present in sham aged mice. …”
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The role of PTEN in human bone marrow-derived mesenchymal stem cells mediated tumor cells suppression. by Toh, Xin Yi.

“…Our laboratory has previously observed tumor suppression in glioma-bearing mice co-injected with human bone marrow-derived mesenchymal stem cells. …”
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Evaluation of the Digital Ventilated Cage® system for circadian phenotyping by Tir, S, Foster, RG, Peirson, SN

“…Home cage activity in C57BL/6J mice was recorded under a range of lighting conditions, along with circadian clock-deficient cryptochrome-deficient mice (Cry1−/−, Cry2−/− double knockout). …”

Study of heat transfer through micro-structured surfaces by Chin, Wei Hao

“…Each chip has a different microstructure in the form of very small and elongated pin-fins, which will in turn affect the critical heat flux of each component. …”
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Implementation of frequency analysis modules for audio coding on GPU by Meher, Subrat.

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Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors by Wang, Xuesong, Ray, Rashmi, Kratochvil, Sven, Melzi, Eleonora, Lin, Ying‐Cing, Giguere, Sophie, Xu, Liling, Warner, John, Cheon, Diane, Liguori, Alessia, Groschel, Bettina, Phelps, Nicole

“…Here we report a one‐step CRISPR/Cas9 KI methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice. We validate this technology with the rapid generation of three BCR KI lines expressing native human precursors, instead of computationally inferred germline sequences, to HIV broadly neutralizing antibodies. …”
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Metronidazole causes skeletal muscle atrophy and modulates muscle chronometabolism by Manickam, Ravikumar, Oh, Hui Yun Penny, Tan, Chek Kun, Paramalingam, Eeswari, Wahli, Walter

“…Furthermore, metronidazole in SPF mice decreases hind limb muscle weight and results in smaller fibers in the tibialis anterior muscle. …”
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Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye by Fan, Yanliang, Zheng, Xiaofeng, Berggren, Per-Olof, Loo, Joachim Say Chye, Yusuf Ali

“…Here, we show that islet rejection in the ACE of mice can be significantly suppressed through local delivery of rapamycin by carefully designed sustained-release microparticles. …”
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Obesity-driven reprogramming of lung macrophages by Pohan, Clarice

“…Upon further investigation, we found that AMs from high-fat diet fed obese (>30wks) mice had larger lipid droplets than those from young lean (<12wks) and age-matched lean (>30wks) mice. …”
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PIERCE1: a determinant of left-right asymmetry in mammals by Farley, H

“…<p>The study of mice with heart and situs defects can provide useful models for improving our understanding of congenital heart defects in humans. …”

Cortical regulation of sleep by Krone, LB

“…First, I present laminar recordings of neocortical activity during sleep in wild type mice, which suggest that layer 5 actively drives slow waves. …”

Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis by Alvarez-Martinez, M, Cox, LS, Pearson, CF, Branchett, WJ, Chakravarty, P, Wu, X, Slawinski, H, Al-Dibouni, A, Samelis, VA, Gabryšová, L, Priestnall, SL, Suárez-Bonnet, A, Mikolajczak, A, Briscoe, J, Powrie, F, O'Garra, A

“…Double-deficient Prdm1^fl/flMaf^fl/flCd4^Cre mice infected with Helicobacter hepaticus developed severe colitis with an increase in T_H1/NK/ILC1 effector genes in LPLs, while Prdm1^fl/flCd4^Cre and Maf^fl/flCd4^Cre mice exhibited moderate pathology and a less-marked type 1 effector response. …”

Design of wideband low-loss reconfigurable reflectarray antenna by Zhang, Xiran

“…It proposes an RRA design that integrates a PIN diode with air gap. The switch of the reconfigurable unit is directly mounted on the reflective element, reducing the loss introduced by the switching device. …”
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Development of optical transceiver by Sim, Sebastian Shih Wei.

“…For PIN photodiodes, the epitaxial layer was introduced to the structures to act as an intrinsic layer. …”
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Identification and characterisation of the haematopoietic stem/progenitor cells at risk for leukaemia development following radiation exposure by Verbiest, T

“…Finally, we report on a gender-dependent leukaemic progression and characterisation where 3 Gy irradiated male mice only present with acute myeloid leukemia and irradiated female mice mainly develop leukaemia with a lymphoid phenotype. …”

Environmental enrichment preconditioning prevents chronic social defeat stress-induced memory impairment and hippocampal neurodegeneration by Nik Ramli, Nik Nasihah, Shamsul Adzmi, Nur Adzreen, Nasarudin, Siti Nur Atiqah Zulaikah, Hashim, Mohamad Hisham

“…However, there is a paucity of studies examining the effects of environmental enrichment on learning and memory in chronic social defeat stress (CSDS) models. Male C57BL/6N mice were (n=5) housed in enriched environments for 30 days before undergoing daily social defeat stress by ICR strain aggressor mice over 10 days. …”
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Optimized core design of a supercritical carbon dioxide-cooled fast reactor by Handwerk, Christopher S. (Christopher Stanley), 1974-

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Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.

“…Modulation of DNA methylation patterns in the cortex of AL CCH mice was re-modelled and signs of reversal was observed in IF CCH mice across all three timepoints. …”
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Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in mouse by Cruciani-Guglielmacci, Céline, Meneyrol, Kelly, Denom, Jessica, Kassis, Nadim, Rachdi, Latif, Makaci, Fatna, Migrenne-Li, Stéphanie, Daubigney, Fabrice, Georgiadou, Eleni, Denis, Raphaël G., Sanchez-Archidona, Ana Rodriguez, Paul, Jean-Louis, Thorens, Bernard, Rutter, Guy A., Magnan, Christophe, Le Stunff, Hervé, Janel, Nathalie

“…We evidenced a defect in the stimulated insulin secretion in CBS+/- mice with mild and intermediate HHcy, while mice with intermediate HHcy under HFD presented an improvement in insulin sensitivity that compensated for the decreased insulin secretion and permitted them to maintain a glucose tolerance similar to the CBS+/+ mice. …”
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Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status by Kidd, Elliot, Meimaridou, Eirini, Walley, Andrew, Fairbrother, Una

“…We investigated whether Nnt deficient mice have reduced TL and display markers of TOS compared to WT and rescued mice and whether this was tissue specific.…”
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