Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506 by Kotaka, Masayo, Ye, Hong, Alag, Reema, Hu, Guangan, Bozdech, Zbynek, Preiser, Peter Rainer, Yoon, Ho Sup, Lescar, Julien

“…It binds to a α/β protein module of approximately 120 amino acids known as the FK506 binding domain (FKBD), which is found in various organisms, including human, yeast, and Plasmodium falciparum (PfFKBD). Antiparasitic effects of FK506 and its analogues devoid of immunosuppressive activities have been demonstrated. …”
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Finding transcription factor binding motifs for coregulated genes by combining sequence overrepresentation with cross-species conservation by Jia, Hui., Li, Jinming.

“…Compared with the prevailing motif finding software, our method has some advantages in finding transcriptional factor binding motifs for potential coregulated genes if the gene upstream sequences of multiple closely related species are available. Although we used yeast genomes to assess our method in this study, it might also be applied to other organisms if suitable related species are available and the upstream sequences of coregulated genes can be obtained for the multiple closely related species.…”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…To gain further insight into the function of NPC1 and proteins it interacts with we used the yeast orthologue, Ncr1p. I recreated the Δncr1 mutant and characterized the mutant using an array of systematic screens to identify different processes and pathways that may play a role in NPC pathogenesis. …”

Isolation of Bifidobacteria infantis and its antagonistic activity against ETEC 0157 and Salmonella typhimurium S-285 in weaning foods by Mohd Yusof, Rokiah, Haque, Formuzul, Ismail, Maznah, Hassan, Zaiton

“…Trypticase phytone peptone yeast extract agar (TPY) was used as a selective media for the isolation. …”

Structural investigation, computational analysis, and theoretical cryoprotectant approach of antifreeze protein type IV mutants by Eskandari, Azadeh, Leow, Thean Chor, Abdul Rahman, Mohd Basyaruddin, Oslan, Siti Nurbaya

“…In this in silico study, the helical peptide afp1m from an Antarctic yeast AFP was modeled into a sculpin AFPIV, to replace each of its four α-helices in turn, using various computational tools. …”

Prioritising conservation areas in Southeast Asia: highlighting zoological biodiversity hotspots and assessing spatiotemporal patterns of the felids guild by Chiaverini, L

“…Specifically, biodiversity hotspots have originally been identified as those global areas containing at least 0.5% or 1,500 of the World’s vascular plant species as endemic and that have lost at least 70% of their primary vegetation. …”

One Plus One is More than Two: A Practical Combination of Power and Fault Analysis Attacks on PRESENT and PRESENT-Like Block Ciphers by Patranabis, Sikhar, Mukhopadhyay, Debdeep, Breier, Jakub, Bhasin, Shivam

“…We present the first practically realizable sidechannel assisted fault attack on PRESENT, that can retrieve the last round key efficiently using single nibble faults. …”
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THE MAYFLY / by Hazel, James, author 656313

“…When lawyer Charlie Priest is attacked in his own home by a man searching for information he claims Priest has, he is drawn into a web of corruption that has its roots in the last desperate days of World War Two. When his attacker is found murdered the next day, Priest becomes a suspect and the only way to clear his name is to find out about the mysterious House of Mayfly - a secret society that people will kill for. …”

Selective load shedding priority algorithm development by Ong, Jing Xian

“…In modern power systems, load shedding is usually the last resort to maintain system stability. Raising the power generated is the go-to method to tackle increasing load demand. …”
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Nonlinear partial differential equations in neuroscience: from modelling to mathematical theory by Carrillo de la Plata, JA, Roux, P

“…The second part concerns hyperbolic transport equations, namely the model of the Time Elapsed since the last discharge and the jump-based Leaky Integrate and Fire model. …”

Globalization and environmental quality : insights from 128 countries by Le, Ha Chi

“…Fixed Effects (FE) is employed as the main estimation technique while panel Ordinary Least Squares (OLS), Feasible Generalized Least Squares (FGLS) and Driscoll-Kraay (D-K) standard errors estimations are employed as robustness check. …”
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Environmental perspectives of recycling various combustion ashes in cement production – a review by Yin, Ke, Ahamed, Ashiq, Lisak, Grzegorz

“…Herein, recycling various combustion ashes, such as municipal solid waste incineration fly ashes (MSWI FA), municipal solid waste incineration bottom ashes (MSWI BA), coal fly ashes (CFA), coal bottom ashes (CBA), blast furnace slags (BFS), biomass ashes (BIOA), sewage sludge ashes (SSA) and different co-combustion ashes (CCA), were comprehensively reviewed, from environmental perspectives combined with statistical data analysis (e.g. bulk components, trace metals, leaching potential, and etc.), to quantitatively explore their feasibility during cement production. …”
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Use of ladle furnace slag containing heavy metals as a binding material in civil engineering by Xu, Bo, Yi, Yaolin

“…In this context, this study firstly attempted to activate LS with sodium hydroxide (NaOH), sodium sulfate (Na2SO4), and sodium metasilicate (Na2SiO3), and then blended it with ground granulated blast-furnace slag (GGBS) with different LS:GGBS ratios. …”
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Numerical study of trapped vortex combustors characteristics in small ramjets by Chen, Song

“…Impossible utilization of relatively large air-blast fuel injectors in a small combustor provides more difficulties for the design. …”
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The role of Holocene relative sea-level change in preserving records of subduction zone earthquakes by Dura, Tina, Engelhart, Simon E., Vacchi, Matteo, Horton, Benjamin Peter, Kopp, Robert E., Peltier, William Richard, Bradley, Sarah

“…In near-field regions that were located beneath northern hemisphere ice sheets (e.g., western Vancouver Island), RSL fall from a mid-Holocene highstand has limited prehistoric earthquake records to the last 1 ka. In intermediate field regions (e.g., southern Washington and central Oregon), gradual RSL rise over the last ∼7 ka has preserved widespread records of prehistoric earthquakes. …”
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React based web-application for stock price forecasting with a novel stacking algorithm by Mittal, Madhav

“…The model performances are compared against a threshold performance of the “Last Value” algorithm. The “Last Value” algorithm is a naïve algorithm that assumes zero volatility in the data and thus sets all forecasts to be the value of the last observation. …”
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Effectiveness of fludrocortisone plus hydrocortisone versus hydrocortisone alone in septic shock: a systematic review and network meta-analysis of randomized controlled trials by Teja, B, Berube, M, Pereira, TV, Law, AC, Schanock, C, Pang, B, Wunsch, H, Walkey, AJ, Bosch, NA

“…The primary outcome was all-cause mortality at last follow-up. Treatment effects are presented as relative risks (RRs) with 95% credible intervals (CrIs). …”

A comparative study on parameter recovery of three approaches to structural equation modeling by Malhotra, Naresh K., Tomiuk, Marc A., Hwang, Heungsun, Kim, Youngchan, Hong, Sungjin

“…Traditionally, two approaches have been employed for structural equation modeling: covariance structure analysis and partial least squares. A third alternative, generalized structured component analysis, was introduced recently in the psychometric literature. …”
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Geometry of single axis motions using conic fitting by Jiang, G, Tsui, H-T, Quan, L, Zisserman, A

“…The main advantage is that determining only five parameters of a conic from one corresponding point over at least five views is simpler and more robust than determining a fundamental matrix from two views or a trifocal tensor from three views. …”

Interventions for smoking cessation in hospitalised patients by Streck, JM, Rigotti, NA, Livingstone-Banks, J, Tindle, HA, Clair, C, Munafò, MR, Sterling-Maisel, C, Hartmann-Boyce, J

“…Our primary outcome was abstinence from smoking assessed at least six months after discharge or the start of the intervention. …”