Effectiveness of supervised versus self-directed rehabilitation for adults aged 50 years and over with ankle fractures: protocol for the AFTER trial by Keene, DJ, Achten, J, Forde, C, Png, ME, Grant, R, Draper, K, Appelbe, D, Tutton, E, Peckham, N, Dutton, SJ, Lamb, SE, Costa, ML

“…To aid recovery, some patients are referred to physiotherapy, but referral patterns vary, likely due to uncertainty about the effectiveness of this supervised rehabilitation approach. …”

A dormant overmassive black hole in the early Universe by Juodžbalis, I, Maiolino, R, Baker, WM, Tacchella, S, Scholtz, J, D’Eugenio, F, Witstok, J, Schneider, R, Trinca, A, Valiante, R, DeCoursey, C, Curti, M, Carniani, S, Chevallard, J, de Graaff, A, Arribas, S, Bennett, JS, Bourne, MA, Bunker, AJ, Charlot, S, Jiang, B, Koudmani, S, Perna, M, Robertson, B

“…The black hole to host galaxy stellar mass ratio is about 0.4—that is, about 1,000 times above the local relation—whereas the system is closer to the local relations in terms of dynamical mass and velocity dispersion of the host galaxy. This object is most likely an indication of a much larger population of dormant black holes around the epoch of reionization. …”

Impact of the COVID-19 pandemic and a supertyphoon: A quantitative study in Cebu, Philippines by Ylade, M, Adhikari, B, Crisostomo, MV, Daag, JV, Cuachin, AM, Lopez, MH, Macasero, A, Agrupis, KA, Deen, J

“…Households who were financially impacted by Supertyphoon Odette were more likely not have recently migrated to their current residence (p<0.001), and to have lower monthly expenditure (p = 0.020). …”

Geometric latent dirichlet allocation on a matching graph for large-scale image datasets by Philbin, J, Sivic, J, Zisserman, A

“…Applying standard inference techniques to this model enables images likely to contain the same object to be probabilistically grouped and ranked.…”

The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Pounds, R, Croft, W, Pearce, H, Hossain, T, Singh, K, Balega, J, Jeevan, DN, Sundar, S, Kehoe, S, Yap, J, Moss, P, Zuo, J

“…Discussion: These findings reveal profound modulation of the tumour tissue and systemic profile of NK cells which likely contributes to the high rates of local progression and metastasis seen with OC. …”

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms by Citarella, BW, Kartsonaki, C, Ibáñez-Prada, ED, Gonçalves, BP, Baruch, J, Escher, M, Pritchard, MG, Wei, J, Philippy, F, Dagens, A, Hall, M, Lee, J, Kutsogiannis, DJ, Wils, E-J, Fernandes, MA, Tirupakuzhi Vijayaraghavan, BK, Panda, PK, Martin-Loeches, I, Ohshimo, S, Fatoni, AZ, Horby, P, Dunning, J, Rello, J, Merson, L, Rojek, A, Vaillant, M, Olliaro, P, Reyes, LF, ISARIC Clinical Characterisation Group

“…NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). …”

The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…At the moment we are currently lacking reliable methods to predict which patients are more likely to respond to FOLFIRI or FOLFOX, which would allow us to choose the most appropriate therapy for each patient. …”

GIS-based multi-criteria decision analysis model for utility water demand: the case of Lodwar Municipality, Turkana County, Kenya by Wanguba, B, Siriba, DN, Okumu, BO

“…Consequently, the addition of more input variables affecting demand is likely to improve the results over changing aspects within the zones. …”

Evaluating geospatial accuracy for equity analyses: a case study of the U.S. National Bridge Inventory by Gandy, CA, Kang, X, Ritsch, N, Armanios, DE

“…To use more automated processes at these high spatial resolutions, governments and other policy-making entities will likely need to require quality control checks of longitude and latitude infrastructure data. …”

Investigating heterogeneity across autism, ADHD, and typical development using measures of cortical thickness, surface area, cortical/subcortical volume, and structural covariance by Sadat-Nejad, Y, Vandewouw, MM, Cardy, R, Lerch, J, Taylor, MJ, Iaboni, A, Hammill, C, Syed, B, Brian, JA, Kelley, E, Ayub, M, Crosbie, J, Schachar, R, Georgiades, S, Nicolson, R, Anagnostou, E, Kushki, A

“…Discussion: These clusters did not align with existing diagnostic labels, suggesting that brain structure is more likely to be associated with differences in adaptive functioning, IQ, and ADHD features.…”

Delay-and-pay: prolonging pharmaceutical patent protection without paying the ‘price’ by Foss-Solbrekk, K

“…My doctrinal analysis establishes that the generic/biosimilar defendants’ loss is likely undercompensated and the money that national health authorities spent purchasing the more expensive, patented drug whilst the interim injunction remained in effect is not usually compensated following a patent revocation and discharged injunction. …”

Territorial movements of African lions: can waterholes shape multiple central-place territories in a savanna ecosystem? by Dejeante, R, Loveridge, A, Macdonald, D, Madlamoto, D, Chamaille-James, S, Valeix, M

“…We hypothesized that male lions would be more likely to patrol a buffer area around the territory core to defend a core area where social interactions with groupmates occur, whereas female lions would more specifically patrol hunting sites, i.e. waterhole areas. …”

Investigating the role of lysine demethylase UTX-1 in lifespan regulation of C. elegans by Guillermo, A

“…Overall, the work in this thesis, which also includes analysis of <em>cbp-1</em> (H3K27 acetyl transferase), suggests that lifespan regulation due to H3K27 modification is incredibly complex and that longevity is mediated differentially as a consequence of different doses of modifier, and in specific tissues, likely due to transcriptional changes mediated by the demethylase function of UTX-1.…”

On the hidden layer-to-layer topology of the representations of reality realised within neural networks by Gafvert, O, Grindrod, P, Harrington, HA, Higham, CF, Higham, DJ, Yim, KM

“…</p> <p><strong>Findings: </strong>We discuss some of the likely consequences of these relatively unforeseen characteristics and, in particular, the possible vulnerability of such algorithms to non-realistic perturbations. …”

The effects of different solubilizing agents on the transport and pharmacokinetic profiles of indomethacin: in vitro and in vivo approach by Siti Aisyah Zainuddin, Abdul Latip Ab Hamid, Aqila Iman Rafandi, Mashani Mohamad, Khuriah Abdul Hamid, Syed Haroon Khalid

“…No in vitro-in vivo correlation (IVIVC) was observed, likely due to the physicochemical properties of indomethacin and the complex physiological environment in the gastrointestinal (GI) tract. …”
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Investigating the inter-rater reliability and usability of telehealth for home hazard falls-risk assessment after stroke by Ainuddin, Husna Ahmad, Romli, Muhammad Hibatullah, Hamid, Tengku Aizan, Salim, Mazatulfazura S. F., Mackenzie, Lynette

“…Introduction: Stroke survivors are more likely to fall at home. A home hazard assessment may be beneficial to reduce the risk of falling; however, it is resourceful and time-intensive. …”
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Rainfall projection using CIMP6 models of extreme area in Johor by Hamid, H, Rahmat, S N, Kasmin, H, Tukimat, N N

“…This suggests that without mitigation efforts, the area will likely experience decreasing rainfall intensity due to the effects of climate change…”
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Ionic liquid based ultrasonic assisted extraction of flavonoids from Artemisia vulgaris and in vitro evaluation of anticancer activity by Lim, Jin Ru, Chua, Lee Suan, Mustaffa, Azizul Azri, Dawood, Dawood Ali Salim

“…Therefore, this technique was likely to be an efficient extraction of plant flavonoids.…”

Exploratory Study on Customer Requirement in View of Electric Vehicle Development in Malaysia: Electric Vehicles in Malaysia (S/O: 12726) by Ibrahim, Jafni Azhan, Yusoff, Rushami Zien, Osman, Nor Hasni, Mohammed Udin, Zulkifli, Shariff, Kamal Imran, Ahmad, Azhar

“…The aim of this research is to analyze potential car buyers’ awareness towards electric vehicle (EV) and examine the factors that are most likely to affect their choice for EV in Malaysia. …”
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Aeration slab study volume 2 by Rahardjo, Harianto, Indrawan, I Gde Budi, Fakhrur, Rozy Harnas

“…This would mean that the aeration slab promotes water infiltration slightly better than the asphalt pavement but is likely to be much less effective compared to soil under turf cover. …”
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