Negotiating publicity, publicising domesticity: women-authored Heian kana memoirs, circulation, reception, and power by Tome Valencia, I

“…</p> <p>This thesis presents a comparative approach to different modes of authorship, dynamics of patronage, questions of publicity, the circulation of women-authored texts, and their relation with the sphere of domesticity; and finds itself in the intersection between premodern literature and Queer studies.…”

As firm as their foundations: creating transferable adversarial examples across downstream tasks with CLIP by Hu, A, Gu, J, Pinto, F, Kamnitsas, K, Torr, PHS

“…Solely based on open-sourced CLIP vision encoders, this method can produce highly effective adversaries that simultaneously fool more than 20 downstream models spanning 4 common vision-language tasks (semantic segmentation, object detection, image captioning and visual question-answering). Our findings highlight the concerning safety risks introduced by the extensive usage of publicly available foundational models in the development of downstream systems, calling for extra caution in these scenarios.…”

The α-globin super-enhancer acts in an orientation-dependent manner by Kassouf, MT, Francis, HS, Gosden, M, Suciu, MC, Downes, DJ, Harrold, C, Larke, M, Oudelaar, M, Cornell, L, Blayney, J, Telenius, J, Xella, B, Shen, Y, Sousos, N, Sharpe, JA, Sloane-Stanley, J, Smith, AJH, Babbs, C, Hughes, JR, Higgs, DR

“…When the SE is inverted within its normal chromosomal context, expression of its normal targets, the α-globin genes, is severely reduced and the normally silent genes lying upstream of the α-globin locus are upregulated. These findings add to our understanding of enhancer-promoter specificity that precisely activate transcription.…”

Urban trust in Kenya and Tanzania: Cooperation in the provision of public goods by Burbidge, D

“…In Kisumu, in contrast, with participants reflective of the dominant Luo ethnicity, the lack of state provision of public services has seen a feeble and individualistic response. The findings demonstrate how ethnic distribution matters less for public goods provision than commitments amongst citizens themselves and between citizens and local authorities.…”

A tale of disregard? Reception of the jurisprudence of the United Nations Committee on the Rights of Persons with Disabilities before the European Court of Human Rights by Cali, B, Galand, AS

“…By focussing on the right to legal capacity, accessibility and reasonable accommodation, we demonstrate that the transformative jurisprudence of the CRPD Committee was met with visible disregard in Strasbourg. Our findings point to both the importance of specialised human rights treaties and jurisprudence in advancing the rights of historically discriminated groups and the challenges of judicially diffusing transformative protections for the rights of persons with disabilities into general human rights law. …”

Perceived climate risk and stock prices: an empirical analysis of pricing effects by Ameur, HB, Dao, D, Ftiti, Z, Louhichi, W

“…Our results show that perceived climate risk is priced into Standard and Poor's 500 (S&amp;P 500) Index stock returns and is robust when different asset-pricing models are used. Our findings have implications for market participants, as understanding the relationship between perceived climate risk and asset prices is crucial for investors seeking to navigate the financial implications of climate change and for policymakers aiming to promote sustainable financing and mitigate the potential damaging effects of climate risk on financial markets, and a pricing model that accurately incorporates perceived climate risk can facilitate this understanding.…”

Mental disorder and its treatment as a transformative experience by Villiger, D

“…The paper examines pharmacological, psychological, and psychedelic-assisted treatment and reveals that each of them uses a different transformative route to recovery: a finding relevant, for example, to ongoing debates in medical ethics about informed consent.…”

Encephalitis: diagnosis, management and recent advances in the field of encephalitides by Alam, AM, Easton, A, Nicholson, TR, Irani, SR, Davies, NWS, Solomon, T, Michael, BD

“…In parallel, the number of autoimmune encephalitis syndromes has rapidly expanded and clinically characteristic syndromes in association with pathogenic autoantibodies have been defined. By focusing on findings presented at the Encephalitis Society's conference in December 2021, this article reviews the causes, clinical manifestations and management of encephalitis and integrate recent advances and challenges of research into encephalitis.…”

Public functions of political parties in the United Kingdom by Trueblood, L

“…This article challenges this finding by offering a framework, drawn from current case law, for establishing when political parties are exercising public functions. …”

Universal in-context approximation by prompting fully recurrent models by Petrov, A, Lamb, TA, Paren, A, Torr, PHS, Bibi, A

“…While it was recently shown that transformer models do possess this property, these results rely on their attention mechanism. Hence, these findings do not apply to fully recurrent architectures like RNNs, LSTMs, and the increasingly popular SSMs. …”

Multi-level encoding of reward, effort and choice across the frontal cortex and basal ganglia during cost-benefit decision making by Härmson, O, Grennan, I, Perry, B, Toth, R, McNamara, C, Denison, T, Cagnan, H, Manohar, S, Walton, M, Sharott, A

“…Co-active cell assemblies, ensembles of neurons that repeatedly co-activated within short time windows (<25ms), represented the same decision variables, despite the members often having diverse individual coding properties. Together, these findings demonstrate a multi-level encoding structure for cost-benefit computations, where individual neurons are coordinated into larger assemblies that can represent task variables independently of their constituent components. …”

Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults by Urban, BC, Gonçalves, ANA, Loukov, D, Passos, FM, Reiné, J, Gonzalez-Dias, P, Solórzano, C, Mitsi, E, Nikolaou, E, O'Connor, D, Collins, AM, Adler, H, Pollard, A, Rylance, J, Gordon, SB, Jochems, SP, Nakaya, HI, Ferreira, DM

“…However, older adults who were protected from colonization showed increased degranulation of CD8+ T cells, both before and after pneumococcal challenge. These findings suggest age-associated cellular changes, in particular enhanced mucosal inflammation, that may predispose older adults to pneumococcal colonization.…”

Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy by Zheng, SL, Henry, A, Cannie, D, Lee, M, Miller, D, McGurk, KA, Bond, I, Xu, X, Issa, H, Francis, C, De Marvao, A, Theotokis, PI, Buchan, RJ, Speed, D, Abner, E, Adams, L, Aragam, KG, Ärnlöv, J, Raja, AA, Backman, JD, Baksi, J, Barton, PJR, Biddinger, KJ, Boersma, E, Lindgren, CM

“…We demonstrate that polygenic scores predict DCM in the general population and modify penetrance in carriers of rare DCM variants. Our findings may inform the design of genetic testing strategies that incorporate polygenic background. …”

Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes by Dean, S, Gould, MK, Dewar, CE, Schnaufer, AC

“…Our results provide insight into the molecular mechanism of compensation for kDNA loss by showing FO-independent generation of the mitochondrial membrane potential with increased dependence on the ADP/ATP carrier. Our findings also suggest that, in the pathogenic bloodstream stage of T. brucei, the huge and energetically demanding apparatus required for kDNA maintenance and expression serves the production of a single F1FO–ATPase subunit. …”

Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study by Stockdale, L, Sambou, B, Sissoko, M, Egere, U, Sillah, AK, Kampmann, B, Basu Roy, R

“…Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. …”

Disciplining the state: virtue, violence, and state-making in modern China by Thornton, P

“…Scholars of European history assert that war makes states, just as states make war. This study finds that in China, the challenges of governing produced a trajectory of state-building in which the processes of moral regulation and social control were at least as central to state-making as the exercise of coercive power. …”

Self-diagnosis of mental disorders: a qualitative study of attitudes on Reddit by Foulkes, L, Underhill, R

“…Together, these themes highlight that there is considerable anger, derision and criticism targeted towards people who self-diagnose with mental disorders, and that this is particularly targeted towards adolescents who self-diagnose on or as a result of social media. The findings have important implications for understanding how to support and validate people, particularly adolescents, who (sometimes accurately) use diagnostic language to express how they are feeling.…”

The impact of antibiotics on the gut microbiota of children recovering from watery diarrhoea by Le, S-NH, Nguyen Ngoc Minh, C, de Sessions, PF, Jie, S, Tran Thi Hong, C, Thwaites, GE, Baker, S, Pham, DT, Chung The, H

“…These changes included a pronounced, transient overabundance of Enterococcus species and depletion of Bifidobacterium pseudocatenulatum. Our findings demonstrate that antibiotic treatment slows gut microbiota recovery in children following watery diarrhoea.…”

Comparison of physics, chemistry and biology teachers’ perceptions of nature of science and domains of science by Kaya, E, Erduran, S

“…This observation is corroborated through some of the findings from the qualitative data analysis which provides detailed variations among the teachers indicating a complex set of relations between the similarities and differences among teachers’ perceptions across subject specialisms. …”

Addressing Factors that Impact Sexual Well-Being and Intimacy in IBD Patients by Elias, S, Nandi, N, Fourie, S, Grover, L, Newman, KL

“…Purpose of Review: This review details the pathophysiologic mechanisms from medical, surgical to psychosocial factors that illustrate how and why sexual health and intimacy are impacted in IBD. Recent Findings: Recent clinical surveys of practicing gastroenterologists document that clinicians should routinely address sexual health when addressing patient reported outcomes but very few actually make direct inquiry or suggest management into this important aspect of human life. …”