An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…Previous studies, including genome-wide association studies (GWAS), have identified genetic variants near the UGT2A1 and UGT2A2 genes that are linked to anosmia in COVID-19 patients. However, the role of epigenetic changes in the development and persistence of smell loss has not been well explored. …”
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Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…However, it was not known whether these functions are conserved in mammalian cells or if they are linked.</p> <p>To inform on OGFOD1-dependent cellular phenotypes, OGFOD1 defective cells were generated by genome editing using the CRISPR methodology. …”

Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: cohort study by Tsigebrhan, R, Medhin, G, Belina, M, Newton, C, Hanlon, C

“…Structural equation modelling (SEM) was employed to examine direct and indirect pathways linking co-morbid CMD symptoms with QoL or functional disability.…”

Joint modelling of longitudinal data: a scoping review of methodology and applications for non-time to event data by Ouko, RK, Mukaka, M, Ohuma, EO

“…The random effect was the most commonly applied association structure for linking two sub-models (63 studies; 85%). Estimation of model parameters was commonly done using Markov Chain Monte Carlo with Gibbs sampler algorithm (10 studies; 38%) for the Bayesian approach, whereas maximum likelihood was the most common (33 studies; 68.75%) for the frequentist approach. …”

Health economic aspects of childhood excess weight by Onyimadu, O

“…Additionally, electronic health records extracted from the Clinical Practice Research Datalink (CPRD), linked with Hospital Episode Statistics (HES), were analysed to estimate direct healthcare costs attributable to childhood excess weight.…”

Adverse events of common psychiatric medications: an umbrella review by Bartellas, K

“…Many medications were linked to adverse events through a weak or moderate strength of association and additional factors contributed to the variability in adverse outcome reporting aside from patient characteristics. …”

Human agency and instrumental rationality: applying human capital to gender inequalities and intergenerational stratification by Luo, H

“…</p></br> <p><strong>Contributions</strong></p> <p>Theoretically, this thesis contributes to linking human agency and instrumental rationality to the persistence and transformation of structural inequalities; it also sheds light on education’s potential and limitations as an equalizer. …”

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro,... by Yang, Z, Sheehan, AM, Messer, AE, Tsui, S, Sparrow, A, Redwood, C, Kren, V, Gould, IR, Marston, SB

“…Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca2+ associated with a higher rate of Ca2+ dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy). Cardiomyopathy-linked mutations primarily affect Ca2+ regulation or the PKA-dependent modulatory system, such that Ca2+-sensitivity becomes independent of phosphorylation level (uncoupling) and this could be sufficient to induce cardiomyopathy. …”

Enhancement of lentiviral vector production through alteration of virus-cell interactions by Gelinas, J

“…To support this aim, viruses have been modified, with elements linked to viral pathogenicity removed from their genome and replaced by the genetic material to be delivered. …”

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Setting: UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…The countermeasures are linked to phases of the overarching editorial workflow, to ensure that their implementation is feasible and that they are clearly useful by and for specific role categories within the media.…”

Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Shamsi, ZA, Paraoan, V, Kim, C, Saifuddin, SR, Cosker, TDA, Whitwell, D, Gibbons, CLMH, Stavroulias, D, DiChiara, F

“…Both surgical intervention (p &lt; 0.0001) and clear margins (p = 0.0051) were significantly linked to improved survival. Local recurrence was noted in 28.6% of the 77 surgical cases, and predominantly in the high-grade sarcomas (81.8%). …”

In-silico trials with human modelling and simulation for guiding optimal stratification of atrial fibrillation patients to catheter ablation and pharmacological therapy by Dasí i Martinez, A

“…Different mechanisms of the arrhythmia (i.e., stable micro-re-entries, wavefront meandering, transient rotors and wave breakups) have been linked to specific ionic current dysregulations and their relationship with the structurally-remodelled substrate (i.e., presence of low voltage areas and atrial enlargement).…”

Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth by Pollock, K, Cheeseman, H, McFarlane, L, Day, S, Tolazzi, M, Turner, H, Joypooranachandran, J, Shramko, K, Dispinseri, S, Mundsperger, P, Bontjer, I, Lemm, N-M, Coelho, S, Tanaka, M, Cole, T, Korber, B, Katinger, D, Ward, A, Scarlatti, G, Sanders, R, Sattentau, Q, Shattock, R

“…</p> <br> <p><strong>Methods:</strong> Healthy adult volunteers were enrolled into one of five groups (A to E) each receiving a different schedule of one of two consensus Env immunogens (ConM SOSIP, ConS UFO, either unmodified or stabilised by chemical cross-linking, followed by a boost with two mosaic Env immunogens (Mos3·1 and Mos3·2). …”

Multi-colony coral skeletal Ba/Ca from Singapore’s turbid urban reefs : relationship with contemporaneous in-situ seawater parameters by Tanzil, Jani Thuaibah Isa, Goodkin, Nathalie Fairbank, Sin, T. M., Chen, Mengli, Fabbro, Gareth Nicholas, Boyle, E. A., Lee, A. C., Toh, K. B.

“…There was also no clear relationship between Ba/Cacoral and skeletal luminescence G/B (a coral proxy strongly linked with salinity and river runoff). This implies that (1) the incorporation of terrestrially derived humic-like substances into the coral is independent of Ba, and (2) it is likely factors other than freshwater discharge/flood events are driving the poor reproducibility of Ba/Cacoral and disconnect with BaSW at our study sites. …”
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Formulating a Way Forward Strategy for Malaysia Cross Border Inland Port Using SWOT and TOWS Analysis by Lamsali, Hendrik, Mad Lazim, Halim, Osman, Wan Nadzri, Salleh, Mohamed Najib, Iteng, Rosman, Yiaw, Michael Tio Boon, Abdul Razak, Muhamad Badrul Shah, Ja’afar, Harlina Suzana

“…The development of adequate infrastructure, including well-connected road networks and direct rail links, should be a top priority for the government through NCIA. …”
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Single-molecule diagnostics to support curative interventions for tuberculosis and HIV by Dougan, Tyler J.

“…In this thesis, I describe the advancement of digital enzyme-linked immunosorbent assay (ELISA) protein detection methods in service of curing these two deadly infectious diseases. …”
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Multilayered siRNA nanoparticles as a delivery system for extended gene silencing effect by Ng, Alice Jie Ying

“…For instance, an elevated expression of secreted protein acidic and rich in cysteine (SPARC) is linked with fibrosis and the inhibition of SPARC expression reduces fibrosis. …”
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Novel nitric oxide donors for the dispersal and control of Pseudomonas aeruginosa biofilms by Poh, Wee Han

“…In the second study, the application of cephalosporin-linked diazeniumdiolate NO donors, which are stable until activation by bacterial specific β-lactamases present within biofilms, were evaluated. …”
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Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis by Yildiz, O, Hunt, GP, Schroth, J, Dhillon, G, Spargo, TP, Al-Chalabi, A, Koks, S, Turner, MR, Shaw, PJ, Henson, SM, Iacoangeli, A, Malaspina, A

“…Low levels of resolvins and downregulation of their membrane receptors in blood mononuclear cells are linked to a faster progression of ALS. Higher mononuclear cell expression of resolvin receptors is a predictor of longer survival. …”