Dose escalation pre-clinical trial of novel DOK7-AAV in mouse model of DOK7 congenital myasthenia by Cossins, J, Kozma, I, Canzonetta, C, Hawkins, A, Beeson, D, Sepulveda, P, Dong, YY

“…Treated mice became at least as strong as wild-type littermates, as demonstrated by using an inverted screen hang test, a rotarod test and a grip strength test. …”

Sensitive detection of PIK3CA Exon 20 H1047R breast cancer based on lowcost intercalary dye SYBR Green I real-time qPCR assay by Desriani, Azamris, Rustamadji, Primariadewi, Abna, Inherni Marti, Ibadurrahman, Irsyad, Fuad, Asrul Muhammad, Nurdiani, Dini, Yuliawati, Yuliawati, Herawati, Neng, Fitria, Najmiatul, Warisman, Muhammad Ali, Utami, Nuruliawaty

“…Genotyping of 15 DNA breast cancer patient samples showed a wild-type genotype, which was in 100% agreement with the PCR sequencing result. …”
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Unveiling perspectives of Islam : seeing through the eyes of Singapore's educated Chinese youths who subscribe to No religion by Nur Ameera Amirrudin

“…Finally, while the negative perceptions of respondents are rather mild, these data reveal that actions should be taken to curb this negativity.…”
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α-amination of aldehydes catalyzed by in situ generated hypoiodite by Tian, Jie-Sheng., Ng, Jeffrey Kang Wai., Wong, Jiun-Ru., Loh, Teck-Peng.

“…This approach has several advantages: it is a metal-free oxidation that works under mild reaction conditions; furthermore, it has a wide substrate scope and does not give toxic by-products from the co-oxidant that is used.…”
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Comparative statics with adjustment costs and the Le Chatelier principle by Dekel, E, Quah, JK-H, Sinander, L

“…We show that comparative-statics conclusions may be drawn under the usual ordinal complementarity assumptions on the objective function, assuming very little about costs: only a mild monotonicity condition is required. We use this insight to prove a general Le Chatelier principle: under the ordinal complementarity assumptions, if short-run adjustment is subject to a monotone cost, then the long-run response to a shock is greater than the short-run response. …”

Gold-catalyzed cyclization of yndiamides with isoxazoles via α-imino gold Fischer carbenes by Tong, Z, Smith, PJ, Pickford, HD, Christensen, KE, Anderson, EA

“…The reaction proceeds rapidly under mild conditions, with high regioselectivity being achieved by introducing a subtle steric bias between the nitrogen substituents on the yndiamide. …”

Engineering the frontier orbitals of a diazadiborinine for facile activation of H2, NH3, and an isonitrile by Su, Yuanting, Li, Yongxin, Ganguly, Rakesh, Kinjo, Rei

“…Thus, the 1,3,2,5‐diazadiborinine readily cleaves the H−H bond of dihydrogen and an N−H bond of ammonia under mild conditions. Moreover, it reacts with 2,6‐dimethylphenylisonitrile in a [4+1] cycloaddition at room temperature.…”
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Effect of Z19n, a synthetic compound, on Cutibacterium acnes growth and biofilm by Choo, Ying

“…As a chronic inflammatory skin disease of the pilosebaceous units and one of the most common skin disorders in the world, acne has affected 88% of adolescents aged 13-19 in Singapore.[1] Treatment for acne is the use of antibiotics. For mild to moderate acne, topical antibiotics are given while oral antibiotics are given to treat moderate to severe acne. …”
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Stable signal recovery in compressed sensing with a structured matrix perturbation by Yang, Zai, Zhang, Cishen, Xie, Lihua

“…Unlike existing robust signal recoveries with the recovery error growing linearly with the perturbation level, this paper analyzes the CS problem subject to a structured perturbation to provide conditions for stable signal recovery under measurement noise. Under mild conditions on the perturbed sensing matrix, similar to that for the standard CS, it is shown that a sparse signal can be stably recovered by ℓ1 minimization. …”
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Well-posedness and stability of a stochastic neural field in the form of a partial differential equation by Carrillo de la Plata, JA, Roux, P, Solem, S

“…In this article, we transform the problem through a suitable change of variables into a nonlinear Stefan-like free boundary problem and use its representation formulae to construct local-in-time smooth solutions under mild hypotheses. Then, we prove that fast-decaying initial conditions and globally Lipschitz modulation functions imply that solutions are global-intime. …”

Developing Wearables and Environmental Sensor Systems for Studying Ecosystems by Chwalek, Patrick, Fang, Cathy Mengying

“…He has been creating a range of systems and tools, including wearables and environmental sensor systems, for researchers to use in the wild. In this interview, Chwalek talks about his experiences of deploying these systems outside the laboratory and shares his insights gained from studying different environments.…”
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Global borders : power, fragility, and ‘a kind of fiction’ (Editorial introduction) by Cahill, Samara

“…Borders may be as solid and politicized as a wall between two neighboring nations, or as enchanting as the demarcation between a cultivated garden and a wild or commons, or as permeable as the barricade of a cell membrane to a virus. …”
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Voyaging : crowdsource application for safe travelling experience by Hong, Li Yan

“…With the growing tourism industry, there is a variety of activities for tourists to participate in, such as hiking, going to beaches, adventuring into the wild and more. This can lead to an increase of potential dangers due to a tourist unfamiliarity with a place and thus getting injured as a result. …”
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Place recognition for unmanned vehicle based on 3D LiDAR and semantic point cloud by Zhao, Yangyang

“…Place recognition is an important task in the computer vision and robotics communities, with a wild application in many fields. For unmanned vehicle, 3D LiDAR and semantic point cloud is always used for place recognition. …”
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Living by the lake: plant food diversity in a prehistoric lake-dwelling community in the Republic of North Macedonia by Holguin, A, Charles, M, Antolín, F, Ballantyne, R, Ergun, M, Hafner, A, Jacomet, S, Lotter, AF, Naumov, G, Reich, J, Soteras, R, Stroud, E, Tinner, W, Wood, R, Bogaard, A

“…The mid-fifth millennium (c.4555–4373 to 4437–4241 cal BCE) waterlogged assemblage contained a diverse spectrum of crops and ‘wild’ resources, providing resilience against crop failure. …”

Are all renewable energy sources the same? a comparative analysis of public perceptions and preferences for renewable energy types in Southeast Asian cities by del Barrio Alvarez, Daniel, Wang, Nan, Sugiyama, Masahiro, Numata, Masako, Thuy, Truong Dang, Abd Aziz, Azlina, Palanca-Tan, Rosalina, Ze Ya, Aung, Yusuf, Ariel Anshory, Abd. Ghani, Awang Noor, Castillo, Gem, Siyaranamual, Martin Daniel

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Certified grasping by Aceituno-Cabezas, Bernardo, Ballester, Jose, Rodriguez, Alberto

“…We develop convex-combinatorial models for each of these certificates, which can be expressed as simple semi-algebraic relations under mild-modeling assumptions, such as point-fingers and frictionless contact. …”
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Cyclodextrin-functionalized thiophene-based copolymers and their guest-host recognition behaviour by Soheila Bahmanjah.

“…These copolymers are quantitatively and rapidly converted into functionalized polymers under mild conditions by post polymerization reactions with 6^A-amino-6^A-alpha-deoxy-cyclodextrin and 6^A-amino-6^A-beta-deoxy-cyclodextrin.These polythiophene derivatives exhibit a highly conjugated form in the solid state at room temperature and their molecular recognition behaviour has been investigated. …”
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Virtual reality for medical application II by Yang, Cheng Yee

“…The project presents the use of Virtual Reality system combines with Cognitive Behavioural Therapy in helping users or patients who have a mild-to-moderate mental health problem. Cognitive Behavioural Therapy considered as a new approach to psychotherapy that alleviates “bad” emotions and some minor mental illness with the use of a combination of cognitive and behavioral therapies. …”
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New insights into the genetic etiology of Alzheimer’s disease and related dementias by Bellenguez, C, Küçükali, F, Jansen, IE, Amin, N, Ahmad, S, Lovestone, S, Smith, AD, Warden, D, Wilcock, G, Laitinen, T, van Duijn, CM

“…We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the <i>APOE</i> ε4 allele.…”