Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study by Shil, RSK, Seed, A, Franklyn, NE, Sargent, BF, Wood, GK, Huang, Y, Dodd, KC, Lilleker, JB, Pollak, TA, Defres, S, Jenkins, TM, Davies, NWS, Cousins, DA, Zandi, MS, Jackson, TA, Benjamin, LA, Easton, A, Solomon, T, Bradley, JR, Chinnery, PF, Smith, CJ, Nicholson, TR, Carson, A, Thomas, RH

“…Those receiving either statins or angiotensin converting enzyme (ACE) inhibitors had a lower risk of impairment in ADLs (OR 0.09, p = 0.0006, 0.17, p = 0.03). …”

Characterisation of the genomes of brain metastases by Ulahannan, D

Student teachers learning to use Assessment for Learning in schools by Tan Chia Chun, D

Remote digital cognitive assessment reveals cognitive deficits related to hippocampal atrophy in autoimmune limbic encephalitis: a cross-sectional validation study by Shibata, K, Attaallah, B, Tai, X-Y, Trender, W, Hellyer, PJ, Hampshire, A, Irani, SR, Manohar, SG, Husain, M

“…The global score on the online cognitive tasks correlated significantly with the established Addenbrooke’s Cognitive Examination III (ACE) pen-and-paper test. Deficits in visuospatial processing and language were identified in ALE compared to controls using remote digital testing but not using the ACE, highlighting higher sensitivity of computerised testing to residual cognitive impairment. …”

Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…All were female and demonstrated continuous GAD65 autoantibody production throughout long-term follow-up. Five of seven had temporal lobe epilepsy, three had T1DM and two had had bilateral hippocampal sclerosis. …”

SARS-CoV-2 evolution during treatment of chronic infection by Kemp, SA, Collier, DA, Datir, RP, Ferreira, IATM, Gayed, S, Jahun, A, Hosmillo, M, Rees-Spear, C, Mlcochova, P, Lumb, IU, Roberts, DJ, Chandra, A, Temperton, N, Sharrocks, K, Blane, E, Modis, Y, Leigh, KE, Briggs, JAG, van Gils, MJ, Smith, KGC, Bradley, JR, Smith, C, Doffinger, R, Ceron-Gutierrez, L, Barcenas-Morales, G, Pollock, DD, Goldstein, RA, Smielewska, A, Skittrall, JP, Gouliouris, T, Goodfellow, IG, Gkrania-Klotsas, E, Illingworth, CJR, McCoy, LE, Gupta, RK

“…The spike deletion mutant ΔH69/ΔV70 had a twofold higher level of infectivity than wild-type SARS-CoV-2, possibly compensating for the reduced infectivity of the D796H mutation. …”

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

“…Antigen-specific T-cell responses were also quantified by intracellular cytokine staining and flow cytometry. Older adults had attenuated T-helper (Th) response to vaccination, which was associated with weaker antibody responses and decreased SARS-CoV-2 neutralisation. …”
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Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community by Zhang, Chengyu, Sánchez, Benjamín J., Li, Feiran, Cheng, Eiden Wei Quan, Scott, William T., Liebal, Ulf W., Blank, Lars M., Mengers, Hendrik G., Anton, Mihail, Rangel, Albert Tafur, Mendoza, Sebastián N., Zhang, Lixin, Nielsen, Jens, Lu, Hongzhong, Kerkhoven, Eduard J.

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