Evaluation of diabetic wound healing properties of moringa oleifera lam using in vitro and in vivo wound models by Muhammad Amali, Abubakar

“…Therefore, may serve as a lead in drug discovery for diabetic wound healing.…”
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The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research by Sanfelice, D, Antolin, A, Crisp, A, Chen, Y, Bellenie, B, Brennan, P, Edwards, A, Müller, S, Al-Lazikani, B, Workman, P

“…These high-quality reagents are essential for exploring the function of individual proteins in complex biological systems, such as cells and organisms, and for validating proteins as potential therapeutic targets. …”

The role of fibroblasts in cancer progression, therapy resistance and field cancerization by Chan, Jeremy Soon Kiat

“…The overexpression or knockdown of specific nuclear receptors in CAFs resulted in the attenuation of one or more aggressive phenotypes in tumor epithelial cells, namely, proliferation, invasiveness, drug resistance, energy metabolism and oxidative stress. …”
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Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

“…The computational models offer a platform for investigating drug effects on cardiac function aiding cardiovascular drug development.…”

Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…The primary outcome is tolerability, whereby the combination is deemed intolerable in a patient if drug-related toxicities in the first four months of treatment lead to: either drug being discontinued; delays in treatment exceeding 28 consecutive days; or death. …”

Nuclear magnetic resonance spectroscopic studies of the structure and interactions between hepatitis B virus core and surface antigens with peptides by Muhamad, Azira

“…There are several approaches in designing an antiviral drug based on the virus life cycle. This study focuses on two antiviral approaches. …”
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Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
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Peripheral Nervous System Modulation with Wireless Cellular Sized Freestanding Injectable Devices by Patel, Preet

“…One of the foundations of neural interface and bioelectronic medicine is the electrical stimulation of excitable cells, to interface the body with electronics and treat a variety of diseases. …”
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Hybrid, nanoscale phospholipid/block copolymer vesicles by Lim, Seng Koon, Hoog, Hans-Peter de, Nallani, Madhavan, Bo, Liedberg, Parikh, Atul N.

“…In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.…”
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Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities by Ding, Feiqing, Leow, Min Li, Ma, Jimei, William, Ronny, Liao, Hongze, Liu, Xue-Wei

“…Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μm. …”
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Therapeutic and immunomodulatory functions of the translocator protein in Alzheimer's disease by Fairley, Lauren H.

“…Lastly, treatment with TSPO ligands attenuates mitophagy impairments and modulates mitochondrial dynamics in neuroblastoma cells expressing mutant tau and APP. Taken together, these findings suggest that TSPO plays a neuroprotective role in AD pathology and highlights its therapeutic potential as a drug target for AD.…”
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Discovery of stabilized functional mutants of human aquaporin 1 by Soh, Miao Yi

“…Aquaporins (AQPs) are essential water channel proteins found in the cell membranes of all forms of life. In this project, a random mutagenesis library for human aquaporin 1 (hAQP1) is generated and screened for functional mutants. …”
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Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…In vivo, muscle and neuronal cells are post-mitotic, and their function is predominantly regulated by proteostasis, a multilayer molecular process that maintains a delicate balance of protein homeostasis. …”

Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…However, it is conspicuously absent from human cells, thus establishing its biosynthetic pathways as important potential drug targets. …”
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Lipid-coated hybrid nanoparticles for enhanced bacterial biofilm penetration and antibiofilm efficacy by Lee, Hiang Wee, Kharel, Sharad, Loo, Joachim Say Chye

“…Antibiotic-loaded nanoparticles have gained traction as a potential drug delivery system to treat biofilm infections. …”
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Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng

“…In addition, ADE-mediated dengue virus infection of human cell lines and primary PBMCs was inhibited. In a time-of-drug-addition study, luteolin was found to reduce infectious virus particle formation, but not viral RNA synthesis, in Huh-7 cells. …”
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PubMed text data mining automation for biological validation on lists of genes and pathways by Nies, Hui Wen, Zakaria, Zalmiyah, Chan, Weng Howe, Kamsani, Izyan Izzati, Hasan, Nor Shahida

“…A prognostic cancer marker is helpful in oncology to identify the abnormal cancer cells from the collected sample. This marker can be used as an indicator to determine a disease outcome, cancer treatment, and drug discovery. …”
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Natural and synthetic homoisoflavonoids and related compounds for the treatment of macular degeneration by Schwikkard, S., Hiles, J., Opara, Elizabeth, Whitmore, H., Corson, T., Mulholland, D.

“…The inhibition of angiogenesis is a drug target with widespread application. Macular conditions affect around 1.5 million people in the UK, with most of them suffering from age-related macular degeneration. …”

Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines by Stanslas, Johnson, Hagan, Damien J., Ellis, Michael J., Turner, Claire, Carmichael, James, Ward, Wynne, Hammonds, Timothy R., Stevens, Malcolm F. G.

“…Unlike m-AMSA, 14 is not susceptible to P-glycoprotein-mediated drug efflux and retains activity in lung cells with derived resistance to the topoisomerase II inhibitor etoposide.…”

In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy by Guimarães, Pedro PG, Figueroa-Espada, Christian G, Riley, Rachel S, Gong, Ningqiang, Xue, Lulu, Sewastianik, Tomasz, Dennis, Peter S, Loebel, Claudia, Chung, Amanda, Shepherd, Sarah J, Haley, Rebecca M, Hamilton, Alex G, El-Mayta, Rakan, Wang, Karin, Langer, Robert, Anderson, Daniel G, Carrasco, Ruben D, Mitchell, Michael J

“…We demonstrate that our strategy inhibits CyPA in BMECs, preventing MM cell extravasation in vitro. Finally, we show that siRNA-based silencing of CyPA in a murine xenograft model of MM, either alone or in combination with the Food and Drug Administration (FDA)-approved MM therapeutic bortezomib, reduces tumor burden and extends survival. …”
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