Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. MTT assay was performed to test for the growth inhibitory effect of individual drugs and their combinations. …”
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Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer by Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn

“…The present work evaluated the membrane permeability of amorphous drug-polyelectrolyte/drug-protein nanoplexes across Caco-2 cell monolayer in comparison to the native drugs. …”
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Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

“…Understanding the dynamics of membrane protein–ligand interactions within a native lipid bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however, they are often blind to the effects of protein modifications. …”

Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity by Chua, Huey Eng, Zhang, Fan, Zheng, Jie, Mishra, Shital Kumar, Bhowmick, Sourav Saha

“…Here we propose a hybrid modelling approach based on ordinary differential equation (ODE) and machine learning to map network rewiring in the apoptotic pathways that may be responsible for the increase of drug sensitivity of tumour cells in triple-negative breast cancer. …”
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Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy by Goh, Wei Jiang, Lee, Choon Keong, Zou, Shui, Woon, Esther, Czarny, Bertrand, Pastorin, Giorgia

“…Cell-derived nanovesicles (CDNs) are an emerging class of biological drug delivery systems (DDS) that retain the characteristics of the cells they were derived from, without the need for further surface functionalization. …”
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3D bioprinting of high cell concentrations & cell spheroids to achieve physiologically relevant cell environments by Chua, Cliff Dun An

“…Overall, this project may be applicable for in vitro drug testing with 3D models which mimics the actual cellular ECM instead of 2D models which often produce inaccurate clinical results In addition, it can also be used to further understand the cell-cell and cell-matrix interactions during clinical tests and research in the biomedical industry.…”
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Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs by Liu, Xili, Moscvin, Maria, Oh, Seungeun, Chen, Tianzeng, Choi, Wonshik, Evans, Benjamin, Rowell, Sean M., Nadeem, Omar, Mo, Clifton C., Sperling, Adam S., Anderson, Kenneth C., Yaqoob, Zahid, Bianchi, Giada, Sung, Yongjin

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Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells by Head, Sarah A., Shi, Wei, Zhao, Liang, Gorshkov, Kirill, Pasunooti, Kalyan, Chen, Yue, Deng, Zhiyou, Li, Ruo-jing, Shim, Joong Sup, Tan, Wenzhi, Hartung, Thomas, Zhang, Jin, Zhao, Yingming, Colombini, Marco, Liu, Jun O.

“…Itraconazole, a clinically used antifungal drug, was found to possess potent antiangiogenic and anticancer activity that is unique among the azole antifungals. …”
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Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…Here, we report that the whole-tumor cell culture (WTC) ex vivo model could be stably established from all breast tumors with a high success rate (98 out of 116), and it could reassemble the parental tumors with the endogenous microenvironment. …”
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Exploring the roles of mitochondrial-associated microRNAs of head and neck cancer stem cells in drug resistance and tumor recurrence by Zhu, Xiaoning, Subha, Sethu Thakachy, Fong, Voon Hoong, Tan, Wee Lin, Cheah, Yoke Kqueen

“…The primary clinical issues in HNC are drug resistance and tumor recurrence attributed to the presence of cancer stem cells (CSCs). …”
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A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens by Bouchard, G, Zhang, W, Ilerten, I, Li, I, Bhattacharya, A, Li, Y, Trope, W, Shrager, JB, Kuo, C, Ozawa, MG, Giaccia, AJ, Tian, L, Plevritis, SK

“…We propose a quantitative framework that catalogs significant, normalized, colocalizations between pairs of cell subpopulations, enabling comparisons among a variety of biological samples. …”

Effect of antimicrobial agents on biofilm cells and invitro development of resistance in planktonic cells of pseudomonas aeruginosa PA01 by Balasankar Meera Priyadarshini

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Effect of external stimuli on cell adhesion dynamics by Feng, Zhiqin

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Enhanced expression of codon optimized interferon gamma in CHO cells by Yusufi, Faraaz N. K., Yang, Yuansheng, Lee, Dong-Yup, Chung, Bevan Kai-Sheng, Mariati

“…The human interferon-gamma (IFN-γ) is a potential drug candidate for treating various diseases due to its immunomodulatory properties. …”
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Effects of hemodynamic shear stress on circulating tumor cells by How, Yunhan

“…They also exhibit elongated cell morphology, greater drug resistance and higher expression of MnSOD, as compared to normal 231-C3.…”
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Materials approaches for next-generation encapsulated cell therapies by Krishnan, Siddharth R., Langer, Robert, Anderson, Daniel G.

“…Transplanted cells can act as living drug factories capable of secreting therapeutic proteins in vivo, with applications in the treatment of Type 1 diabetes (T1D), blood borne disease, vision disorders, and degenerative neural disease, potentially representing functional cures for chronic conditions. …”
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Real‐time imaging of dynamic cell reprogramming with nanosensors by Wiraja, Christian, Yeo, David Chenloong, Tham, Khek-Chian, Chew, Sharon Wan Ting, Lim, Xinhong, Xu, Chenjie

“…Cellular reprogramming, the process by which somatic cells regain pluripotency, is relevant in many disease modeling, therapeutic, and drug discovery applications. …”
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Establishment and optimization of induced pluripotent stem cell technologies by Amir Morshedi

“…This finding has had tremendous impact on drug discovery and disease modeling and there is great hope for these cells to replenish body cells for therapy. …”
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Cell charactetization in differnet regions of the native annulus fibrous in a porcine intervetebral disc model through cell sorting and molecular analysis by Teo, Tong

“…Hence, there is a need to tap on tissue engineering to build a biological constructs for the replacement of the degenerated tissue. However, the cell biology of the AF is still poorly understood especially the different cell types that exist within the AF. …”
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