The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

“…In an at-tempt to identify immune-derived cells and soluble factors that induce the differentiation of stem cells towards the osteoblast lineage, the interaction between monocytes and osteoblast precursors has proven a potentially promising approach.…”

That mysterious man by Lin, Enyi

“…Xu An is a rookie policeman who is working undercover in the Tang Nightclub as a waiter called Ann. The police suspect that the nightclub is implicated in the drug trade and Zhang Xu, a medicine dealer who is a regular, is involved. …”
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Animal models of human disease 2.0 by Lange, Sigrun, Inal, Jameel

“…The five participating MDPI journals were Biomedicines, Cells, Current Issues in Molecular Biology, Genes, and the International Journal of Molecular Sciences. …”
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Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…Various therapeutic approaches for modulating energy deficits in DS, effects and molecular mechanism of gene therapy and drugs that exert protective effects through modulation of mitochondrial function and attenuation of oxidative stress in DS cells were discussed. …”
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Automated sample preparation systems for medical diagnostics by Johanes Candra, Guo, Xun, Siew, Kok Ewe, Zhang, Meiqing

“…Recent advances in genomics research and the completion of the Human Genome Project have made it possible for scientists to apply genomic knowledge and technologies in various fields, such as medical diagnostics, drug discovery, agriculture, and even defense against the threat of bio-warfare. …”
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Developing a novel approach to map signals required for GalNAcT2 relocation. by Tan, Wei Ling.

“…Glycosylation is an important post-translational modification as it has multiple biological functions like cell-cell communications and cell-matrix interactions. …”
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The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…First, a preclinical study with three different colorectal cancer cell lines was performed to address if SPRTN depletion could make cells more sensitive to the aforementioned drugs. …”

Optimising expression and purification of Dengue soluble E protein by Poh, Nina Yong Xin

“…Successful modification and vector expression in pcDNA3.1 enhance solubility, enabling drug development and testing. This project sets a baseline for future functional and mechanistic understanding. …”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Li, HZ, Pike, ACW, Chang, Y, Prakaash, D, Gelova, Z, Stanka, J, Moreau, C, Scott, HC, Wunder, F, Wolf, G, Scacioc, A, McKinley, G, Batoulis, H, Mukhopadhyay, S, Garofoli, A, Pinto-Fernández, A, Kessler, BM, Burgess-Brown, NA, Štefanić, S, Wiedmer, T, Dürr, KL, Puetter, V, Ehrmann, A, Khalid, S, Sauer, DB

“…Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects. SPNS2 also exports the S1P-mimicking FTY720-P (Fingolimod) and thereby is central to the pharmacokinetics of this drug when treating multiple sclerosis. …”

Activated Metals to Generate Heat for Biomedical Applications by Remlova, Eva, Feig, Vivian Rachel, Kang, Ziliang, Patel, Ashka, Ballinger, Ian, Ginzburg, Anna, Kuosmanen, Johannes, Fabian, Niora, Ishida, Keiko, Jenkins, Joshua, Hayward, Alison, Traverso, Giovanni

“…Delivering heat in vivo could enhance a wide range of biomedical therapeutic and diagnostic technologies, including long-term drug delivery devices and cancer treatments. To date, providing thermal energy is highly power-intensive, rendering it oftentimes inaccessible outside of clinical settings. …”
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Characterization of the translational regulation of BIM 3’ UTR by Ho, Jessie Jia Xin

“…BIM (BCL-2-interacting mediator of cell death) plays a central role in the regulation of the intrinsic apoptotic pathway by controlling the delicate balance between the induction of apoptosis and cell survival. …”
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Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Valsson, Í, Warren, MT, Deane, CM, Magarkar, A, Morris, GM, Biggin, PC

“…However, current models lack robust evaluation and fail on tasks encountered in (hit-to-) lead optimisation, such as ranking the binding affinity of a congeneric series of ligands, thereby limiting their application in drug discovery. Here, we address these issues by first introducing a novel attention-based graph neural network model called AEV-PLIG (atomic environment vector–protein ligand interaction graph). …”

Magnetic Droplet Merging by Hybrid Magnetic Fields by Ray, Ayan, Varma, Vijaykumar B., Wang, Zhaomeng, Wang, Zhiping, Jayaneel, P.J., Sudharsan, Natteri M., Ramanujan, Raju V.

“…The present work can be used for magnetically controlled, remote, wireless and programmable droplet actuation and merging relevant to biomedical assay, cell manipulation, tissue culture, drug efficacy and synthesis of magnet-polymer composite particles.…”
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Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…Moreover, L1 was also identified to increase the expression levels of dopamine-related genes in a LRRK2 G2019S cell-based model. This establishes the potential of L1 as a Nurr1-activating drug and lays the foundation for future development of disease-modifying drugs for PD to prevent or slow down its progression.…”
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In-vitro validation of potential modulators of non-alcoholic fatty liver disease (NAFLD) by Tang, Daryl Woon Tat

“…The only FDA-approved drug for NASH, Rezdiffra, had limited efficacy in patients, highlighting the need for alternative strategies. …”
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Integrate Traditional Chinese Medicine (TCM) into cognitive behavioural therapy to treat postpartum depression in Chinese culture contexts. by Han, Shuyu.

“…Furthermore, women are expected to provide breastfeed after delivery. Taking drugs such as antidepressants will be strongly believed it’s harmful to child. …”
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Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? by Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, Barrio, Jorge R.

“…Two antibodies, aducanumab and lecanemab, have been approved by the U.S. Food and Drug Administration, while a third, donanemab, is under review. …”
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The Mycobacterium tuberculosis cytochrome bcc:aa3 cryo-EM structure and discovery of novel putative cytochrome bcc:aa3 inhibitors by Mathiyazakan, Vikneswaran

“…The structure provides insights into the electron transfer pathways and further understanding on drug interaction with the enzyme complex. A whole cell library screen targeting cyt-bcc:aa3 identified hits that depleted whole cell ATP levels, inhibited growth and dramatically decreased oxygen consumption rate in real-time. …”
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Understanding droplet jetting on varying substrate for biological applications by Lee, Jia Min, Huang, Xi, Goh, Guo Liang, Tran, Tuan, Yeong, Wai Yee

“…Modifying postimpact events, such as spreading, evaporation, and absorption, improves cell viability of printed droplet. Last, applications that leverage on the advantage of pixelation in inkjet printing technology have been shown for drug screening and cell-material interaction studies. …”
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Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

“…Considering the possibility for drug repurposing, we discovered homologous binding sites in other proteins, with ligands that could potentially bind to the novel PTP1B binding sites.…”
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