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261
The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial
Published 2018“…In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative damage contributes to AKI. …”
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Journal Article -
262
Malaria parasite stress tolerance is regulated by DNMT2-mediated tRNA cytosine methylation
Published 2023“…Our findings give insight into a novel molecular mechanism that regulates P. falciparum response to drug treatment and sexual commitment.…”
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Journal Article -
263
Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity
Published 2018“…Our study shows promise for developing new ruthenium drugs, via ligand-based modulation of DNA versus protein binding and thus cytotoxic potential, to target distinguishing epigenetic features of cancer cells.…”
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Journal Article -
264
Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings
Published 2022“…Oral delivery is one of the facile methods for the administration of active ingredients (AI) like nutraceuticals and drugs. However, its intrinsic disadvantages include poor absorption and bioavailability, degradation of the AI during transit through the gastro-intestinal tract (GIT), and a lack of action specificity. …”
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Journal Article -
265
Interaction-mediating sequences within class I viral fusion glycoproteins : their roles in viral infection and in applications
Published 2015“…Class I viral fusion glycoproteins facilitate fusion of the viral envelope with cell membranes and entry of the virus into the cell, through extensive short sequence-specific interactions. …”
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Thesis -
266
Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii
Published 2024“…Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins offer advantages like enhanced specificity and reduced side effects, and there has been tremendous growth in their innovation thanks to modern DNA technologies and AI-driven algorithms. …”
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Thesis -
267
Cortical regulation of sleep
Published 2021“…These experiments revealed unexpected effects of the chemogenetic actuators clozapine-N-oxide (CNO) and Compound 21 (Cmpd21) on sleep in wild type mice, which do not express designer receptors exclusively activated by designer drugs (DREADDs). Finally, I present extensive work on ‘cortical SNAP25-ablated’ (<em>Rbp4-Cre;Ai14;Snap25<sup>fl/fl</sup></em>) mice, which served as a model for chronic silencing of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells. …”
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268
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269
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
Published 2020“…The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass. It is active towards community-acquired and hospital-associated MRSA strains which are resistant to multiple drugs including vancomycin and daptomycin. …”
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Journal Article -
270
Genetic and molecular characterisation of non-tissue culture adapted influenza B viruses detected in Singapore between 2004-2009
Published 2014“…No mutations conferring drug resistance were noticed among the HA and NA proteins analysed. …”
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Thesis -
271
Structural and mechanistic studies of herpes virus proteins
Published 2015“…It can give a better insight to how the virus survives and replicates in host cells. Development of drugs against the herpes viral infections in humans may be guided more effectively. …”
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Thesis -
272
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
Published 2023“…Combination of the CDK4/6 inhibitor ribociclib with the PI3K inhibitor alpelisib showed antitumor activity in estrogen receptor-positive non-basal-like breast cancer patient-derived xenografts, independently of PIK3CA, ESR1 or RB1 mutation, also in drug de-escalation experiments or omitting endocrine therapy. …”
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Journal Article -
273
Designer broad-spectrum polyimidazolium antibiotics
Published 2021“…Our experiments indicate PIM1 binds bacterial cell membranes by hydrophobic and electrostatic interactions, enters cells, and ultimately kills bacteria. …”
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274
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275
You Are the Placebo : Making Your Mind Matter /
Published 2014“…Is it possible to heal by thought alone—without drugs or surgery? The truth is that it happens more often than you might expect. …”
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software, multimedia -
276
Please, let me go /
Published 2017“…From the age of 14, Caitlin was completely controlled, repeatedly raped, provided with alcohol, given drugs, sold and passed on to new gangs over and over again. …”
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277
Glucokinase activity in diabetes: too much of a good thing?
Published 2022“…Because glucose must be metabolised to stimulate insulin release it was initially argued that drugs that stimulate glucokinase (the first enzyme in glucose metabolism) would enhance insulin secretion in diabetes. …”
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278
Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
Published 2018“…Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancer (NSCLC). Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. …”
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Journal Article -
279
Structural study of enteroviruses
Published 2023“…Although they have been studied for decades, few vaccines or drugs are in use. Indeed, many structural details of enterovirus infection, immune response and life cycle remain unknown. …”
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280
Neutron emission studies from miniature and medium size plasma focus device
Published 2010“…Although dense plasma focus devices have attracted the attention of scientific community since 1960’s as a copious source of fusion neutrons but in the recent years owing to spin-off in the applications of compact and portable table top neutron sources in wider domain, like noninvasive interrogation of explosives and narcotic drugs (by using Pulsed Fast/Thermal Neutron Analysis (PFTNA) technique), dark matter research, radioisotope production, medical neutron therapy and soil humidity measurements, there has been renewed interest across the globe for the development of sub-kilojoule range, low energy small plasma focus device (hereafter called ‘Miniature Plasma Focus i.e. …”
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