Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…While there are few clinically approved anti-IAV drugs for therapeutic and prophylactic use, these drugs have also been challenged by the emergence of drug resistance, toxicity, adverse effects and low efficacy. …”
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Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect by Tan, Yang Fei, Lee, Ying Shi, Seet, Li-Fong, Ng, Kee Woei, Wong, Tina T., Venkatraman, Subbu

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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil by Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär

“…Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. …”
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Development of red/near-infrared fluorescent molecules and macromolecules for biomedical applications by Yang, Cangjie

“…The hydrophobic layer of side chain was used to physically entrap drugs for chemotherapy. To address the potential problem of drug leakage, we utilized amphiphilic random copolymers containing drug-modified units as side chain of conjugated polymers instead in Chapter 7. …”
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Targeted therapy to gastric cancer by Hou, Qian.

“…Unlike drugs that target specific kinases, the 8 drugs identified here indirectly inhibit multiple signaling pathways which are essential for cancer cell survival. …”
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Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6 by Zhang, Xiulin, He, Yang, Zhang, Xiaolu, Fu, Bo, Song, Zidai, Wang, Liang, Fu, Rui, Lu, Xuancheng, Xing, Jin, Lv, Jianyi, Guo, Meng, Huo, Xueyun, Liu, Xin, Lu, Jing, Du, Xiaoyan

“…Promising results suggest that TLR6 may be a potential candidate immunotherapy drug for H. pylori infection.…”
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Real-time microscopic study and modeling of the disruption of bacterial swarming motion by Lu, Shengtao

“…In biology, certain bacteria such as the Gram-positive Bacillus subtilis can differentiate into swarming cells and move rapidly across the surface of a semisolid media in multicellular rafts or clusters. …”
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Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…IB was found to mediate necrosis in colorectal cancer cells. On the other hand, CM was found to mediate apoptosis in the cancer cells. …”
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Proteomics and metabolomics analysis of cellular responses to β-blocker carvedilol by Wang, Mingxuan

“…One solution to alleviating this problem is to gain a better understanding of existing drug-cell interactions that will provide valuable insights into drug redeployment and new drug design. …”
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Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

Monitoring the efficacy of magnetofection with Au-Fe3O4 nanoparticles by Sim, Stanley Siong Wei

“…However, there are not many efficient gene or drug delivery vectors around in the industry for such application. …”
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Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data by Liu, Hui, Zhang, Fan, Mishra, Shital Kumar, Zhou, Shuigeng, Zheng, Jie

“…The experimental results demonstrate that our model can uncover drug-induced alterations in signaling pathways in cancer cells. …”
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Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…The combination of 5FU-CaCO3np (1.875 μM) and TQ (30 μM) showed significantly superior anti-colon cancer effects to 5FU-CaCO3np alone in terms of cell proliferation and migration inhibition, cell apoptosis induction, and spheroid growth suppression in CT26 cells (p < 0.05), with strong interactions between the drugs and targets (E-cadherin, Bcl-2, PCNA, and MMP-2). …”
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Construction and characterization of a Lactococcus lactis in-trans surface display system harboring murine glycosylated tyrosinase related protein-2 by Kalyanasundram, Jeevanathan

“…The Generally Regarded as Safe (GRAS) status of LAB such as Lactococcus lactis coupled with non-recombinant strategy of in-trans surface display system, provide a safe platform for therapeutic drug and vaccine development. However, therapeutic proteins fused with cell-wall anchoring motif production are predominantly limited to prokaryotic expression system. …”
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Development of ratiometric fluorescent pH nanoprobe to study endocytic uptake pathways of antisense oligonucleotides by Liew, Donn Hou Feng

“…Antisense therapy as a treatment option has received widespread consideration as only knowledge of a nucleotide sequence is necessary for drug design. However, one challenge of antisense therapy concerns attaining effective delivery to intracellular targets. …”
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Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models by Saedi, Tayebeh Azam

“…The disease is characterized by increasing of immature white blood cells called "blasts", and is estimated to account for about 3% of incident cases for all kind of cancer worldwide. …”
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Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…We also find that the LbL film conformation is key to maintaining therapeutic efficacy as thicker films hinder IL-12 delivery. …”
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Curved oligonucleotide constructs as human topoisomerase I inhibitors : a mechanistic study of the enzyme’s recognizing passway. by Zhao, Guanjia.

“…It is discovered that there are more than normal amount of Topo I enzymes in the tumour cells, making it a potential drug target for cancer therapy. …”
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Coupling photo-responsive transmembrane ion transport with transition metal catalysis by Chao, X, Johnson, T, Temian, M-C, Docker, A, Wallabregue, A, Scott, A, Conway, S, Langton, M

“…This work demonstrates that artificial transporters enable control over catalysis inside artificial cell-like systems, which could form the basis of biocompatible nanoreactors for applications such as drug synthesis and delivery or to mediate phototargeted catalyst delivery into cells.…”

Semiconducting photothermal nanoagonist for remote-controlled specific cancer therapy by Zhen, Xu, Xie, Chen, Jiang, Yuyan, Ai, Xiangzhao, Xing, Bengang, Pu, Kanyi

“…Our study thus demonstrates the first example of ion-channel-specific and remote-controlled drug-delivery system for cancer cell therapy.…”
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