A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases by Lim, Wei Shan, Chen, Kenneth, Chong, Tsung Wen, Xiong, Gordon Minru, Birch, William R., Pan, Jisheng, Lee, Bae Hoon, Er, Pei Shan, Salvekar, Abhijit Vijay, Venkatraman, Subbu S., Huang, Yingying

“…On deployment, the device swells to co-apt with the ureteric wall and ensure drug availability to these tissues. …”
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Nanosized silica particles for achiral drug separation by Tan, Timothy Thatt Yang.

“…It is widely recognized that the full potential of rapid chromatography can be realized with very small support particulates and tailor-made chiral stationary phase. …”
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18F-labelling of new chemotypes for drug discovery by Khotavivattana, T

“…<b>Chapter 2</b> describes a novel silver-mediated ¹⁸F-labelling of Ar-SCF3, Ar OCF3 and Ar-OCF2H, including [¹⁸F]Riluzole, the ¹⁸F labelled version of a drug for treatment of amyotrophic lateral sclerosis (ALS). …”

Amplifying signals in the tumor microenvironment for drug development and diagnostics by Martin Alonso, Maria Carmen

“…Leveraging advancements in high throughput screening and in deep learning, we contribute important tools for the effective design of conditional drugs that require the cleavage of a protease substrate to unleash drug cytotoxicity. …”
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Layer-by-layer assembled micro and nano carriers for drug delivery applications by Mutukumaraswamy Shaillender

“…In nano- or microparticulate drug delivery, both control of the drug release and interaction of the particles with the cellular environment are critical attributes. …”
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Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

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Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy by Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal

“…However, realizing the full potential of this approach requires a clear comprehension of the genetic dependencies underlying drug synergy. …”
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A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence by Lim, Wei Shan

“…The first layer is needed for sustained release of drug while the second layer is required for close contact with urothelial wall. …”
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Characterization and evaluation of bilayer coating for enhanced localization and sustained drug delivery for fibrosis-induced ureteral stricture by Chin, Jia Wen

“…The usage of a bilayer coating, consisting of a hydrogel layer and a drug-loaded polymer layer, allows for direct contact with the ureter walls upon swelling and drug delivery through the urothelium. …”
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Increasing antibiotic activity by rapid bioorthogonal conjugation of drug to resistant bacteria using an upconverted light-activated photocatalyst by Du, Quanchao, Wu, Xiangyang, Bi, Wuguo, Xing, Bengang, Yeow, Edwin Kok Lee

“…We demonstrate that the mode of action is due to increased inhibition of peptidoglycan cell wall biosynthesis. The findings in this study demonstrate that on-demand NIR-light activated bioorthogonal conjugation of Van to microbes is a viable alternative treatment in combating drug-resistant bacteria.…”
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Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The studies described in this thesis were undertaken to evaluate the application of paper spray mass spectrometry for direct analysis of small molecule drugs and biomarker in dried matrix spot samples. …”
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Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY) by Karadzas, M

“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”

Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents by Zhang, Kaixi, Raju, Cheerlavancha, Zhong, Wenbin, Pethe, Kevin, Gründling, Angelika, Chan-Park, Mary B.

“…In addition to the emergence of resistance to last resort drugs, bacteria escape antibiotics killing by forming complex biofilms. …”
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AI is a viable alternative to high throughput screening: a 318-target study by Wallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel, Eckert, Sam, de Oliveira, Saulo, Suterwala, Shabbir, PrasadPrasad, Srimukh Veccham Krishna, Shek, Stefani, Contreras, Stephanie, Hare, Stephanie, Palazzo, Teresa, O’Brien, Terrence E., Van Grack, Tessa, Williams, Tiffany, Chern, Ting-Rong, Kenyon, Victor, Lee, Andreia H., Cann, Andrew B., Bergman, Bastiaan, Anderson, Brandon M., Cox, Bryan D., Warrington, Jeffrey M., Sorenson, Jon M., Goldenberg, Joshua M., Young, Matthew A., DeHaan, Nicholas, Pemberton, Ryan P., Schroedl, Stefan, Abramyan, Tigran M., Gupta, Tushita, Mysore, Venkatesh, Presser, Adam G., Ferrando, Adolfo A., Andricopulo, Adriano D., Ghosh, Agnidipta, Ayachi, Aicha Gharbi, Mushtaq, Aisha, Shaqra, Ala M., Toh, Alan Kie Leong, Smrcka, Alan V., Ciccia, Alberto, de Oliveira, Aldo Sena, Sverzhinsky, Aleksandr, de Sousa, Alessandra Mara, Agoulnik, Alexander I., Kushnir, Alexander, Freiberg, Alexander N., Statsyuk, Alexander V., Gingras, Alexandre R., Degterev, Alexei, Tomilov, Alexey, Vrielink, Alice, Garaeva, Alisa A., Bryant-Friedrich, Amanda, Caflisch, Amedeo, Patel, Amit K., Rangarajan, Amith Vikram, Matheeussen, An, Battistoni, Andrea, Caporali, Andrea, Chini, Andrea, Ilari, Andrea, Mattevi, Andrea, Foote, Andrea Talbot, Trabocchi, Andrea, Stahl, Andreas, Herr, Andrew B., Berti, Andrew, Freywald, Andrew, Reidenbach, Andrew G., Lam, Andrew, Cuddihy, Andrew R., White, Andrew, Taglialatela, Angelo

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Utilizing food waste and thermoplastic starch (TPS) in 3D printed PLA formulations for sustainable and customizable controlled delivery systems by Wang, Liwen

“…With the addition of TPS, the drug release profile can be adjusted from 8 – 120 hours using different TPS ratios and different printed wall thicknesses. …”
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SP.236 / ES.SP236 Exploring Pharmacology, Spring 2009 by Gusman, Mariya, Fallows, Zak

“…From Abilify to Zyrtec, the world is full of interesting drugs. Such substances have cured diseases, started wars, and ended careers. …”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…However, it is conspicuously absent from human cells, thus establishing its biosynthetic pathways as important potential drug targets. Our knowledge about the biological roles of galactofuranose in cells is hampered by a dearth of methods by which to study it. …”
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Ion doping behavior of stöber silica-nanosynthesis and application by Song, Xiaohui

“…Besides, we can dope positive charged organic molecules inside silica nanoparticle, such as dyes, drugs, and so on. The above synthesis control is important to silica application in biosensors, drug delivery, catalysts, and battery. …”
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Construction and characterization of a Lactococcus lactis in-trans surface display system harboring murine glycosylated tyrosinase related protein-2 by Kalyanasundram, Jeevanathan

“…The Generally Regarded as Safe (GRAS) status of LAB such as Lactococcus lactis coupled with non-recombinant strategy of in-trans surface display system, provide a safe platform for therapeutic drug and vaccine development. However, therapeutic proteins fused with cell-wall anchoring motif production are predominantly limited to prokaryotic expression system. …”
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Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy by Goh, Wei Jiang, Lee, Choon Keong, Zou, Shui, Woon, Esther, Czarny, Bertrand, Pastorin, Giorgia

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