Structure of the C-terminal domain of the multifunctional ICP27 protein from herpes simplex virus 1 by Nordlund, Par, Patel, Vidhi, Dahlroth, Sue-Li, Rajakannan, Venkatachalam, Ho, Hai Ting, Cornvik, Tobias

“…ICP27 plays an essential role in viral transcription, nuclear export of intronless RNAs, translation of viral transcripts, and virion host shutoff function. It has also been implicated in several signaling pathways and the prevention of apoptosis. …”
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Dynamical systems guided design and analysis of silicon oscillators for central pattern generators by Cohen, Avis H., Li, Fei, Basu, Arindam, Chang, Chip Hong

“…Switched-capacitor (SC) and floating-gate wide input linear range operational transconductance amplifier (FGOTA) based approaches have been proposed to implement the resistor. Both approaches enable controllable and large resistances in a small area. …”
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Lipopolysaccharide neutralizing peptide–porphyrin conjugates for effective photoinactivation and intracellular imaging of gram-negative bacteria strains by Liu, Fang, Soh, Annie Yan Ni, Lim, Yingjie, Mohanram, Harini, Bhattacharjya, Surajit, Xing, Bengang

“…A simple and specific strategy based on the bioconjugation of a photosensitizer protophophyrin IX (PpIX) with a lipopolysaccharide (LPS) binding antimicrobial peptide YI13WF (YVLWKRKRKFCFI-Amide) has been developed for the effective fluorescent imaging and photodynamic inactivation of Gram-negative bacterial strains. …”
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Phase-preserved optical elevator by Luo, Yuan, Zhang, Baile, Han, Tiancheng, Chen, Zhi, Duan, Yubo, Chu, Chia-Wei, Barbastathis, George, Qiu, Cheng Wei

“…However, very few experiments have been done so far to verify this dual-recovery property from viewpoints of both ray trajectory and optical path length simultaneously. …”
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Laplacian embedded regression for scalable manifold regularization by Chen, Lin, Tsang, Ivor Wai-Hung, Xu, Dong

“…Semi-supervised learning (SSL), as a powerful tool to learn from a limited number of labeled data and a large number of unlabeled data, has been attracting increasing attention in the machine learning community. …”
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Mechanism of graphene oxide as a growth template for complete reduced graphene oxide coverage on SiO2 substrate by Nimmo, Myra A., Huang, Jingfeng, Fam, Derrick Wen Hui, He, Qiyuan, Chen, Hu, Zhan, Da, Faulkner, Steve, Tok, Alfred Iing Yoong

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Experimental and computational thermal analysis of vortex flame in meso-scale combustor by Khaleghi, Mostafa

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Robust engineering in maintainability of building by Ismail, Neza

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Intelligent diagnostic feedback in virtual learning environment by Guo, Ruisheng

“…On the other hand, according to the National Student Survey (NSS) reports (2007-2010), in England, about half of students and 35% of students (2011 -2014), and 30% of students (2015-2016) did not agreed with that: 1, feedback on their work has been prompt; 2, feedback on their work has helped them clarify things they did not understand; 3, they have received detailed comments on their work. …”
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DNA extraction methodologies for ultra long nanopore sequencing to determine chromosome specific rodent telomere lengths by Kidd, Elliot, Mooruth, Ravi, Meimaridou, Eirini, Walley, Andrew, Fairbrother, Una

“…Ultra long sequencing has been attempted with Human TL (5-15Kb) with some success. …”
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Turning trash into treasure: exploring the potential of AI in municipal waste management - an in-depth review and future prospects by El Jaouhari, Asmae, Samadhiya, Ashutosh, Kumar, Anil, Mulat-Weldemeskel, Eyob, Luthra, Sunil, Kumar, Rajesh

“…Even though much research has been conducted in this field, relatively few review studies assess how advancements in AI techniques can contribute to the sustainable advancement of MWM systems. …”
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Pyrroloquinoline quinone aza-crown ether complexes as biomimetics for lanthanide and calcium dependent alcohol dehydrogenases by Vetsova, Violeta A., Fisher, Katherine R., Lumpe, Henning, Schäfer, Alexander, Schneider, Erik K., Weis, Patrik, Daumann, Lena J.

“…Lanthanides are the most recent group of metal ions that have been shown to be important in biology, that is, in quinone-dependent methanol dehydrogenases (MDH). …”
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Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study by Olsen, JR, Gallacher, J, Finlay, AY, Piguet, V, Francis, NA

“…</p> <p><strong>Interpretation</strong> One in ten children with molluscum contagiosum is likely to have a substantial effect on their quality of life and therefore treatment should be considered for some children, especially those with many lesions or who have been identified as having a severe effect on quality of life. …”

Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

“…Specifically, the regulation of the myofilament by multiple distinct nanodomains has not been investigated. Similarly, the impact of PKA phase separation on myofilament function is unknown. …”

Investigation into ion channel- and nitric oxide-mediated vasodilation in resistance arteries by Wallis, LE

“…While the role of L-type VGCCs has been long established in larger arteries, recent research has highlighted the importance of T-type VGCCs in smaller resistance arteries and their potential involvement in vasodilation. …”

Tissue and spatially resolved immune drivers of fibrotic pulmonary sarcoidosis by Weeratunga, P

“…This gene has previously been found to drive increased synthesis of extracellular matrix proteins via TGF-β activation. …”

Controlling selectivity in the reductive activation of CO2 by mixed sandwich uranium(iii) complexes by Tsoureas, N, Castro, L, Kilpatrick, A, Cloke, FGN, Maron, L

“…Electrochemical studies on both the uranium(III) complexes and the dimeric uranium(IV) CO2 reduction products have been carried out and all exhibit quasi reversible redox processes; in particular, the similarities in the U(III)/U(IV) redox couples suggest that the selectivity in the outcome of CO2 reductive activation by these complexes is steric in origin rather than electronic. …”

Co-designing the implementation of a rural health systems-strengthening rheumatic heart disease program with remote First Nations Australian communities using Theory of Change by Jones, B, Mitchell, A, Haynes, E, Howard, NJ, Wade, V, Pears, C, Rossingh, B, Gatti, J, Ramadani, S, Corpus, E, Yan, J, Marangou, J, Kaethner, A, Bailey, M, Francis, JR, English, M, Nagraj, S

“…Task-sharing using local healthcare workers, trained to screen for active RHD cases (using handheld ultrasound with remote support from experts), has been proposed as a means of improving early detection whilst also strengthening referral pathways. …”

Social bonding among children in joint physically active play by Jefferies, M

“…Each of these features has been associated with interpersonal affiliation in either human or non-human primates. …”

Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care by Olsen, JR, Piguet, V, Gallacher, J, Francis, NA

“…An association between the presence of atopic eczema (AE) and MC has been shown, but the subsequent risk of developing MC in children with a diagnosis of AE is not known.…”