Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein by Loh, Jia Tong, Teo, Joey Kay Hui, Lam, Kong-Peng

“…However, the precise mechanism controlling calprotectin production during SARS-CoV-2 infection remains elusive. In this study, we showed that Dok3 adaptor restrains calprotectin production by neutrophils in response to SARS-CoV-2 spike (S) protein engagement of TLR4. …”
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The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2 by Nuccetelli, V, Mghezzi-Habellah, M, Deymier, S, Roisin, A, Gérard-Baraggia, F, Rocchi, C, Coureux, P, Gouet, P, Cimarelli, A, Mocquet, V, Fiorini, F

“…These results unveil a novel, multi-faceted mechanism by which SARS-CoV-2 evades the host’s defenses and manipulates cellular components. …”

COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection by Mahyuddin, Aniza P., Swa, Hannah L. F., Weng, Ruifen, Zhang, Jingxian, Dhanaraj, Janice P., Sesurajan, Binny P., Rauff, Mary, Dashraath, Pradip, Kanneganti, Abhiram, Lee, Rachel, Wang, Lin-Fa, Young, Barnaby Edward, Tambyah, Paul A., Lye, David C., Chai, Louis Y. A., Yee, Sidney, Choolani, Mahesh, Mattar, Citra N. Z.

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Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses by Scheim, David E., Parry, Peter I., Rabbolini, David J., Aldous, Colleen, Yagisawa, Morimasa, Clancy, Robert, Borody, Thomas J., Hoy, Wendy E.

“…Notably, the two human betacoronaviruses that express a sialic acid-cleaving enzyme are benign, while the other three—SARS, SARS-CoV-2 and MERS—are virulent. RBC aggregation experimentally induced in several animal species using an injected polysaccharide caused most of the same morbidities of severe COVID-19. …”
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Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

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A 9.87 nW 1 kS/s 8.7 ENOB SAR ADC for implantable epileptic seizure detection microsystems by Do, Anh Tuan, Lam, Chun Kit, Tan, Yung Sern, Yeo, Kiat Seng, Cheong, Jia Hao, Yao, Lei, Tan, Meng Tong, Je, Minkyu

“…This paper presents an ultra low-power SAR ADC in 0.18 μm CMOS technology for epileptic seizure detection applications. …”
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Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…We demonstrated that the production of SARS-CoV-2 VLPs using this cell pool was scalable up to a stirred-tank 2 L bioreactor in fed-batch mode. …”
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Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain by Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D, Nussenzweig, Michel C, Chakraborty, Arup K

“…The Omicron variant of SARS-CoV-2 is not effectively neutralized by most antibodies elicited by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing antibodies. …”
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Dynamics of SARS-CoV-2 infection over two epidemic waves in Manaus, Brazil: A serological study of seven thousand blood donors by Alexander, N, Dye, C, Busch, MP, Buss, L, Prete, CA, Brady, OJ, Mee, P, Abrahim, CMM, Crispim, MAE, da Costa, AG, Salomon, T, Mayaud, P, Oikawa, MK, Faria, NR, Sabino, EC

“…Seroconversion was inferred by a mixture model for serial values from the Abbott Architect SARS-CoV-2 nucleocapsid (N) IgG assay. We estimated the number of suspected COVID-19 hospitalizations arising from each infection over calendar time. …”

Clinical course, immunogenicity, and efficacy of BNT162b2 mRNA vaccination against SARS-CoV-2 infection in liver transplant recipients by Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R. X., Kang, Jaclyn Y. T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby Edward, Muthiah, Mark D.

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The cellular characterization of SARS-CoV-2 spike protein in virus-infected cells using the receptor binding domain binding specific human monoclonal antibodies by Chan, Conrad En-Zuo, Ng, Ching-Ging, Lim, Angeline Pei-Chew, Seah, Shirley Lay-Kheng, Chye, De-Hoe, Wong, Steven Ka-Khuen, Lim, Jie-Hui, Lim, Vanessa Zi-Yun, Lai, Soak-Kuan, Wong, Pui-San, Leong, Kok-Mun, Liu, Yi-Chun, Sugrue, Richard J., Tan, Boon Huan

“…A human monoclonal antibody panel (PD4, PD5, PD7, SC23, and SC29) was isolated from the B cells of convalescent patients and used to examine the S protein in SARS-CoV-2-infected cells. While all five antibodies bound conformational-specific epitopes within SARS-CoV-2 spike (S) protein, only PD5, PD7, and SC23 were able to bind to the receptor binding domain (RBD). …”
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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

“…The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. …”
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Urban flood detection with Sentinel-1 Multi-Temporal Synthetic Aperture Radar (SAR) observations in a Bayesian Framework : a case study for Hurricane Matthew by Lin, Nina Yunung, Yun, Sang-Ho, Bhardwaj, Alok, Hill, Emma M.

Subjects: “…SAR Intensity Time Series…”
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Socioeconomic inequalities in risk of infection with SARS-CoV-2 delta and omicron variants in the UK, 2020-22: analysis of the longitudinal COVID-19 Infection Survey by Razieh, C, Shabnam, S, Dambha-Miller, H, Morris, EJA, Yates, T, Chudasama, Y, Zaccardi, F, Gillies, C, Banerjee, A, Pareek, M, Lacey, B, White, M, Khunti, K, Islam, N

“…<p><strong>Objective</strong> To explore the risk of a positive test result for the delta or omicron variant of the SARS-CoV-2 virus in different occupations and deprivation groups in the UK.…”

Effectiveness and user experience of nose and throat swabbing techniques for SARS-CoV-2 detection: results from the UK COVID-19 National Testing Programme by Futschik, ME, Kulasegaran-Shylini, R, Blandford, E, Harper, S, Chapman, D, Turek, E, Agrawal, S, Phillips, V, Fordham, H, Chan, L, Kidd, M, Dodgson, A, Klapper, PE, Sudhanva, M, Vipond, R, Hopkins, S, Peto, T, Tunkel, S, Fowler, T

“…Background: The UK’s National Health Service Test and Trace (NHSTT) program aimed to provide the most effective and accessible SARS-CoV-2 testing approach possible. Early user feedback indicated that there were accessibility issues associated with throat swabbing. …”

Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

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Virus-like particles of nodavirus displaying the receptor binding domain of SARS-CoV-2 spike protein: a potential VLP-based COVID-19 vaccine by Kumar, Kiven, Tan, Wen Siang, Arshad, Siti Suri, Ho, Kok Lian

“…Since the outbreak of the coronavirus disease 2019 (COVID-19), various vaccines have been developed for emergency use. The efficacy of the initial vaccines based on the ancestral strain of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has become a point of contention due to the emergence of new variants of concern (VOCs). …”
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Literasi politik pengundi di Parlimen Port Dickson, Negeri Sembilan by Siti Fatimah Ismail, Junaidi Awang Besar

“…Majoriti pengundi menyatakan bahawa ideologi parti politik memainkan peranan penting dalam keputusan mengundi, dengan sebahagian besar mereka lebih cenderung memilih parti berbanding calon. …”
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Very good lives : the fringe benefits of failure and the importance of imagination / by Rowling, J. K., July 31, 1965-, author 466163

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Rumah kedai bersejarah pekan lama Kimanis (1939 - 2021) kajian ke atas kemusnahan semula jadi by Baszley Bee Basrah Bee, Zainuddin Baco

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